The impact of inoculation with the inactivated COVID-19 vaccine on the outcomes of in vitro fertilization and embryo transfer: a cohort study of 1,258 women from Sichuan, China
ObjectiveThis study aimed to assess the impact of inoculation with the inactivated coronavirus disease 2019 (COVID-19) vaccine on the outcomes of in vitro fertilization and embryo transfer (IVF-ET).MethodsFrom January 2021 to December 2022, patients undergoing their first cycle of IVF-ET at the Repr...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1491259/full |
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| author | Jia-jing Wei Yu Qiu Yu Qiu Mei Leng Fu-rui Chen Fu-rui Chen Mei-yu Liang Xi Deng Rong-ning Ma Jing Hei Jesse Li-Ling Yan Gong |
| author_facet | Jia-jing Wei Yu Qiu Yu Qiu Mei Leng Fu-rui Chen Fu-rui Chen Mei-yu Liang Xi Deng Rong-ning Ma Jing Hei Jesse Li-Ling Yan Gong |
| author_sort | Jia-jing Wei |
| collection | DOAJ |
| description | ObjectiveThis study aimed to assess the impact of inoculation with the inactivated coronavirus disease 2019 (COVID-19) vaccine on the outcomes of in vitro fertilization and embryo transfer (IVF-ET).MethodsFrom January 2021 to December 2022, patients undergoing their first cycle of IVF-ET at the Reproductive Medicine Center of Sichuan Provincial Women’s and Children’s Hospital were prospectively enrolled. Based on inoculation with inactivated COVID-19 vaccines before ovarian stimulation (OS) by a gonadotrophin-releasing hormone (GnRH) antagonist or agonist protocol, the patients were divided into the vaccinated group (n = 713) and the unvaccinated group (n = 545). The vaccinated group were sub-grouped based on the dose of inoculation (single dose, n = 74; double dose, n = 275; and triple dose, n = 126) and the interval between the first inoculation and OS (<3 months, n = 65; 3–6 months, n = 123; and >6 months, n = 287).ResultsThe rates of mature oocytes, normal fertilization, cleavage embryo, high-quality cleavage embryo, blastocysts, and high-quality blastocysts were not significantly different between the vaccinated and unvaccinated groups (p > 0.05). For fresh embryo transfer, the implantation rate (IR), the clinical pregnancy rate (CPR), the live birth rate (LBR), the gestational age at delivery, and the birth weight of infants were not significantly different between the two groups (p > 0.05). The IR, CPR, LBR, and birth weight of infants were not significantly different for both the dose and interval subgroups (p > 0.05).ConclusionInactivated COVID-19 vaccines may not affect the outcomes of IVF-ET. |
| format | Article |
| id | doaj-art-5ced8e092dad4f17a5775883af6fa6d3 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-5ced8e092dad4f17a5775883af6fa6d32025-08-20T02:34:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.14912591491259The impact of inoculation with the inactivated COVID-19 vaccine on the outcomes of in vitro fertilization and embryo transfer: a cohort study of 1,258 women from Sichuan, ChinaJia-jing Wei0Yu Qiu1Yu Qiu2Mei Leng3Fu-rui Chen4Fu-rui Chen5Mei-yu Liang6Xi Deng7Rong-ning Ma8Jing Hei9Jesse Li-Ling10Yan Gong11Reproductive Medicine Centre, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaReproductive Medicine Centre, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaReproductive Medicine Centre, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaReproductive Medicine Centre, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaReproductive Medicine Centre, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaReproductive Medicine Centre, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaReproductive Medicine Centre, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaReproductive Medicine Centre, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaCenter of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaReproductive Medicine Centre, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaObjectiveThis study aimed to assess the impact of inoculation with the inactivated coronavirus disease 2019 (COVID-19) vaccine on the outcomes of in vitro fertilization and embryo transfer (IVF-ET).MethodsFrom January 2021 to December 2022, patients undergoing their first cycle of IVF-ET at the Reproductive Medicine Center of Sichuan Provincial Women’s and Children’s Hospital were prospectively enrolled. Based on inoculation with inactivated COVID-19 vaccines before ovarian stimulation (OS) by a gonadotrophin-releasing hormone (GnRH) antagonist or agonist protocol, the patients were divided into the vaccinated group (n = 713) and the unvaccinated group (n = 545). The vaccinated group were sub-grouped based on the dose of inoculation (single dose, n = 74; double dose, n = 275; and triple dose, n = 126) and the interval between the first inoculation and OS (<3 months, n = 65; 3–6 months, n = 123; and >6 months, n = 287).ResultsThe rates of mature oocytes, normal fertilization, cleavage embryo, high-quality cleavage embryo, blastocysts, and high-quality blastocysts were not significantly different between the vaccinated and unvaccinated groups (p > 0.05). For fresh embryo transfer, the implantation rate (IR), the clinical pregnancy rate (CPR), the live birth rate (LBR), the gestational age at delivery, and the birth weight of infants were not significantly different between the two groups (p > 0.05). The IR, CPR, LBR, and birth weight of infants were not significantly different for both the dose and interval subgroups (p > 0.05).ConclusionInactivated COVID-19 vaccines may not affect the outcomes of IVF-ET.https://www.frontiersin.org/articles/10.3389/fendo.2025.1491259/fullSARS-CoV-2inactivated vaccinein vitro fertilizationembryo transferlive birth |
| spellingShingle | Jia-jing Wei Yu Qiu Yu Qiu Mei Leng Fu-rui Chen Fu-rui Chen Mei-yu Liang Xi Deng Rong-ning Ma Jing Hei Jesse Li-Ling Yan Gong The impact of inoculation with the inactivated COVID-19 vaccine on the outcomes of in vitro fertilization and embryo transfer: a cohort study of 1,258 women from Sichuan, China Frontiers in Endocrinology SARS-CoV-2 inactivated vaccine in vitro fertilization embryo transfer live birth |
| title | The impact of inoculation with the inactivated COVID-19 vaccine on the outcomes of in vitro fertilization and embryo transfer: a cohort study of 1,258 women from Sichuan, China |
| title_full | The impact of inoculation with the inactivated COVID-19 vaccine on the outcomes of in vitro fertilization and embryo transfer: a cohort study of 1,258 women from Sichuan, China |
| title_fullStr | The impact of inoculation with the inactivated COVID-19 vaccine on the outcomes of in vitro fertilization and embryo transfer: a cohort study of 1,258 women from Sichuan, China |
| title_full_unstemmed | The impact of inoculation with the inactivated COVID-19 vaccine on the outcomes of in vitro fertilization and embryo transfer: a cohort study of 1,258 women from Sichuan, China |
| title_short | The impact of inoculation with the inactivated COVID-19 vaccine on the outcomes of in vitro fertilization and embryo transfer: a cohort study of 1,258 women from Sichuan, China |
| title_sort | impact of inoculation with the inactivated covid 19 vaccine on the outcomes of in vitro fertilization and embryo transfer a cohort study of 1 258 women from sichuan china |
| topic | SARS-CoV-2 inactivated vaccine in vitro fertilization embryo transfer live birth |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1491259/full |
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