Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men
Abstract Pentosidine is representative of the cross-linked structure of advanced glycation end products (AGEs) and has been suggested as a biomarker to assess bone and muscle quality. As studies on pentosidine in young adult men remain limited, we aimed to clarify the associations of urinary pentosi...
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BMC
2024-11-01
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| Series: | Journal of Physiological Anthropology |
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| Online Access: | https://doi.org/10.1186/s40101-024-00376-1 |
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| author | Takayuki Nishimura Ping Yeap Loh Yoshihito Tomita Ted K. S. Ng Takafumi Maeda |
| author_facet | Takayuki Nishimura Ping Yeap Loh Yoshihito Tomita Ted K. S. Ng Takafumi Maeda |
| author_sort | Takayuki Nishimura |
| collection | DOAJ |
| description | Abstract Pentosidine is representative of the cross-linked structure of advanced glycation end products (AGEs) and has been suggested as a biomarker to assess bone and muscle quality. As studies on pentosidine in young adult men remain limited, we aimed to clarify the associations of urinary pentosidine with musculoskeletal status and physical performance in young men. Participants in this study comprised 32 men (age range: 19–39 years). Anthropometric measurements (body composition by InBody 430; stiffness index by ultrasound), muscle performance (grip strength by dynamometer, thigh muscle thickness by ultrasound), physical performance (functional reach test, 30-s chair stand test, and timed up and go test), and urinary biomarkers (pentosidine, N-telopeptide of type I collagen, and creatinine) were measured. In partial correlation analysis adjusted for age and height, higher urinary pentosidine levels were significantly associated with lower fat-free mass index (rho = − 0.368, p = 0.046), grip strength (rho = − 0.433, p = 0.017), rectus femoris thickness (rho = − 0.393, p = 0.032), and anterior thigh thickness (rho = − 0.416, p = 0.022), and a marginally inverse correlation was noted between urinary pentosidine levels and functional reach test (rho = − 0.327, p = 0.078). Our findings suggest that pentosidine correlates inversely with a few muscle and physical performance indicators. Pending future validations, urinary pentosidine may be a biomarker of AGEs in young men. |
| format | Article |
| id | doaj-art-5ce7febf91094b5483f3d24343a6a685 |
| institution | OA Journals |
| issn | 1880-6805 |
| language | English |
| publishDate | 2024-11-01 |
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| series | Journal of Physiological Anthropology |
| spelling | doaj-art-5ce7febf91094b5483f3d24343a6a6852025-08-20T02:22:26ZengBMCJournal of Physiological Anthropology1880-68052024-11-014311610.1186/s40101-024-00376-1Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult menTakayuki Nishimura0Ping Yeap Loh1Yoshihito Tomita2Ted K. S. Ng3Takafumi Maeda4Department of Human Life Design and Science, Faculty of Design, Kyushu UniversityDepartment of Human Life Design and Science, Faculty of Design, Kyushu UniversityDepartment of Physical Therapy, School of Rehabilitation, Tokyo Professional University of Health ScienceRush University Medical Center, Rush Institute for Healthy AgingDepartment of Human Life Design and Science, Faculty of Design, Kyushu UniversityAbstract Pentosidine is representative of the cross-linked structure of advanced glycation end products (AGEs) and has been suggested as a biomarker to assess bone and muscle quality. As studies on pentosidine in young adult men remain limited, we aimed to clarify the associations of urinary pentosidine with musculoskeletal status and physical performance in young men. Participants in this study comprised 32 men (age range: 19–39 years). Anthropometric measurements (body composition by InBody 430; stiffness index by ultrasound), muscle performance (grip strength by dynamometer, thigh muscle thickness by ultrasound), physical performance (functional reach test, 30-s chair stand test, and timed up and go test), and urinary biomarkers (pentosidine, N-telopeptide of type I collagen, and creatinine) were measured. In partial correlation analysis adjusted for age and height, higher urinary pentosidine levels were significantly associated with lower fat-free mass index (rho = − 0.368, p = 0.046), grip strength (rho = − 0.433, p = 0.017), rectus femoris thickness (rho = − 0.393, p = 0.032), and anterior thigh thickness (rho = − 0.416, p = 0.022), and a marginally inverse correlation was noted between urinary pentosidine levels and functional reach test (rho = − 0.327, p = 0.078). Our findings suggest that pentosidine correlates inversely with a few muscle and physical performance indicators. Pending future validations, urinary pentosidine may be a biomarker of AGEs in young men.https://doi.org/10.1186/s40101-024-00376-1PentosidineMuscle strengthUltrasoundBone massMuscle thickness |
| spellingShingle | Takayuki Nishimura Ping Yeap Loh Yoshihito Tomita Ted K. S. Ng Takafumi Maeda Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men Journal of Physiological Anthropology Pentosidine Muscle strength Ultrasound Bone mass Muscle thickness |
| title | Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men |
| title_full | Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men |
| title_fullStr | Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men |
| title_full_unstemmed | Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men |
| title_short | Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men |
| title_sort | urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men |
| topic | Pentosidine Muscle strength Ultrasound Bone mass Muscle thickness |
| url | https://doi.org/10.1186/s40101-024-00376-1 |
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