Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver
Hepatocellular carcinoma (HCC) generally occurs on the background of chronic liver disease. Chronic hepatitides B and C and alcoholic liver disease are well-known risk factors for HCC, and it is uncommon in noncirrhotic liver. Extrahepatic metastasis seldom occurs in patients with early stage intrah...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/512849 |
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| author | Soo Ya Bae Hyun Jung Kim Hyun Ho Oh Min Kwan Kwon Jong Ho Lee Moon Park Byeong Seok Sohn |
| author_facet | Soo Ya Bae Hyun Jung Kim Hyun Ho Oh Min Kwan Kwon Jong Ho Lee Moon Park Byeong Seok Sohn |
| author_sort | Soo Ya Bae |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) generally occurs on the background of chronic liver disease. Chronic hepatitides B and C and alcoholic liver disease are well-known risk factors for HCC, and it is uncommon in noncirrhotic liver. Extrahepatic metastasis seldom occurs in patients with early stage intrahepatic HCC and isolated bone metastases as a first documented extrahepatic metastasis is unusual presentation. In this report, we present a rare case of small solitary HCC (<3 cm) in noncirrhotic liver, presenting isolated bone metastases as a sole manifestation in patient with no well-known risk factors. This case suggests that HCC should be considered as one of differential diagnoses in patient presenting with multiple bone metastases, even in the absence of liver cirrhosis. |
| format | Article |
| id | doaj-art-5ce39889dd244564972529a88baabaad |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-5ce39889dd244564972529a88baabaad2025-02-03T07:25:44ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/512849512849Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic LiverSoo Ya Bae0Hyun Jung Kim1Hyun Ho Oh2Min Kwan Kwon3Jong Ho Lee4Moon Park5Byeong Seok Sohn6Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of KoreaDepartment of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of KoreaDepartment of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of KoreaDepartment of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of KoreaDepartment of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of KoreaDepartment of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of KoreaDepartment of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of KoreaHepatocellular carcinoma (HCC) generally occurs on the background of chronic liver disease. Chronic hepatitides B and C and alcoholic liver disease are well-known risk factors for HCC, and it is uncommon in noncirrhotic liver. Extrahepatic metastasis seldom occurs in patients with early stage intrahepatic HCC and isolated bone metastases as a first documented extrahepatic metastasis is unusual presentation. In this report, we present a rare case of small solitary HCC (<3 cm) in noncirrhotic liver, presenting isolated bone metastases as a sole manifestation in patient with no well-known risk factors. This case suggests that HCC should be considered as one of differential diagnoses in patient presenting with multiple bone metastases, even in the absence of liver cirrhosis.http://dx.doi.org/10.1155/2015/512849 |
| spellingShingle | Soo Ya Bae Hyun Jung Kim Hyun Ho Oh Min Kwan Kwon Jong Ho Lee Moon Park Byeong Seok Sohn Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver Case Reports in Oncological Medicine |
| title | Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver |
| title_full | Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver |
| title_fullStr | Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver |
| title_full_unstemmed | Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver |
| title_short | Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver |
| title_sort | multiple bone metastases as the first manifestation of hepatocellular carcinoma in patient with noncirrhotic liver |
| url | http://dx.doi.org/10.1155/2015/512849 |
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