Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models
Transcutaneous intraluminal impedance measurement (TIIM) is a new method to cutaneously measure gastric contractions by assessing the attenuation dynamics of a small oscillating voltage emitted by a battery-powered ingestible capsule retained in the stomach. In the present study, we investigated whe...
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| Format: | Article |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/691532 |
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| author | Michael D. Poscente Gang Wang Dobromir Filip Polya Ninova Gregory Muench Orly Yadid-Pecht Martin P. Mintchev Christopher N. Andrews |
| author_facet | Michael D. Poscente Gang Wang Dobromir Filip Polya Ninova Gregory Muench Orly Yadid-Pecht Martin P. Mintchev Christopher N. Andrews |
| author_sort | Michael D. Poscente |
| collection | DOAJ |
| description | Transcutaneous intraluminal impedance measurement (TIIM) is a new method to cutaneously measure gastric contractions by assessing the attenuation dynamics of a small oscillating voltage emitted by a battery-powered ingestible capsule retained in the stomach. In the present study, we investigated whether TIIM can reliably assess gastric motility in acute canine models. Methods. Eight mongrel dogs were randomly divided into 2 groups: half received an active TIIM pill and half received an identically sized sham capsule. After 24-hour fasting and transoral administration of the pill (active or sham), two force transducers (FT) were sutured onto the antral serosa at laparotomy. After closure, three standard cutaneous electrodes were placed on the abdomen, registering the transluminally emitted voltage. Thirty-minute baseline recordings were followed by pharmacological induction of gastric contractions using neostigmine IV and another 30-minute recording. Normalized one-minute baseline and post-neostigmine gastric motility indices (GMIs) were calculated and Pearson correlation coefficients (PCCs) between cutaneous and FT GMIs were obtained. Statistically significant GMI PCCs were seen in both baseline and post-neostigmine states. There were no significant GMI PCCs in the sham capsule test. Further chronic animal studies of this novel long-term gastric motility measurement technique are needed before testing it on humans. |
| format | Article |
| id | doaj-art-5cdfa328728243d68119677d90582116 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-5cdfa328728243d68119677d905821162025-02-03T07:25:53ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/691532691532Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine ModelsMichael D. Poscente0Gang Wang1Dobromir Filip2Polya Ninova3Gregory Muench4Orly Yadid-Pecht5Martin P. Mintchev6Christopher N. Andrews7Centre for Bioengineering and Research, University of Calgary, Engineering Complex, 2500 University Drive NW, Calgary, AB, T2N 1N4, CanadaCentre for Bioengineering and Research, University of Calgary, Engineering Complex, 2500 University Drive NW, Calgary, AB, T2N 1N4, CanadaDepartment of Electrical and Computer Engineering, University of Calgary, Engineering Complex, 2500 University Drive NW, Calgary, AB, T2N 1N4, CanadaDivision of Pediatrics, Faculty of Medicine, University of Calgary, Calgary, AB, T2N 1N4, CanadaFaculty of Veterinary Medicine, University of Calgary, Calgary, AB, T2N 1N4, CanadaDepartment of Electrical and Computer Engineering, University of Calgary, Engineering Complex, 2500 University Drive NW, Calgary, AB, T2N 1N4, CanadaCentre for Bioengineering and Research, University of Calgary, Engineering Complex, 2500 University Drive NW, Calgary, AB, T2N 1N4, CanadaDivision of Gastroenterology, Faculty of Medicine, University of Calgary, Calgary, AB, T2N 1N4, CanadaTranscutaneous intraluminal impedance measurement (TIIM) is a new method to cutaneously measure gastric contractions by assessing the attenuation dynamics of a small oscillating voltage emitted by a battery-powered ingestible capsule retained in the stomach. In the present study, we investigated whether TIIM can reliably assess gastric motility in acute canine models. Methods. Eight mongrel dogs were randomly divided into 2 groups: half received an active TIIM pill and half received an identically sized sham capsule. After 24-hour fasting and transoral administration of the pill (active or sham), two force transducers (FT) were sutured onto the antral serosa at laparotomy. After closure, three standard cutaneous electrodes were placed on the abdomen, registering the transluminally emitted voltage. Thirty-minute baseline recordings were followed by pharmacological induction of gastric contractions using neostigmine IV and another 30-minute recording. Normalized one-minute baseline and post-neostigmine gastric motility indices (GMIs) were calculated and Pearson correlation coefficients (PCCs) between cutaneous and FT GMIs were obtained. Statistically significant GMI PCCs were seen in both baseline and post-neostigmine states. There were no significant GMI PCCs in the sham capsule test. Further chronic animal studies of this novel long-term gastric motility measurement technique are needed before testing it on humans.http://dx.doi.org/10.1155/2014/691532 |
| spellingShingle | Michael D. Poscente Gang Wang Dobromir Filip Polya Ninova Gregory Muench Orly Yadid-Pecht Martin P. Mintchev Christopher N. Andrews Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models Gastroenterology Research and Practice |
| title | Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models |
| title_full | Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models |
| title_fullStr | Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models |
| title_full_unstemmed | Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models |
| title_short | Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models |
| title_sort | transcutaneous intraluminal impedance measurement for minimally invasive monitoring of gastric motility validation in acute canine models |
| url | http://dx.doi.org/10.1155/2014/691532 |
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