Rare epithelial gastric cancers: a review of the current treatment knowledge
Gastric cancer (GC), one of the tumours with the highest mortality worldwide, is not a homogeneous disease, showing different features according to location, macroscopic aspect, histotype and molecular alterations. Adenocarcinoma is the most frequent epithelial GC (95%), the remaining 5% comprising...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Therapeutic Advances in Medical Oncology |
| Online Access: | https://doi.org/10.1177/17588359241255628 |
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| author | Angelica Petrillo Margaret Ottaviano Luca Pompella Emilio Francesco Giunta Pasquale Pisapia Gianpaolo Marte Andrea Tufo Sara Di Lorenzo Jessica Orefice Chiara Miceli Umberto Malapelle Bruno Daniele Ferdinando De Vita |
| author_facet | Angelica Petrillo Margaret Ottaviano Luca Pompella Emilio Francesco Giunta Pasquale Pisapia Gianpaolo Marte Andrea Tufo Sara Di Lorenzo Jessica Orefice Chiara Miceli Umberto Malapelle Bruno Daniele Ferdinando De Vita |
| author_sort | Angelica Petrillo |
| collection | DOAJ |
| description | Gastric cancer (GC), one of the tumours with the highest mortality worldwide, is not a homogeneous disease, showing different features according to location, macroscopic aspect, histotype and molecular alterations. Adenocarcinoma is the most frequent epithelial GC (95%), the remaining 5% comprising rare epithelial tumours with their peculiarities, behaviour and incidence <6 cases/100,000/year. Due to the low number of cases, many aspects must be elucidated in this context. In this narrative review, we highlight the importance of a better understanding of rare GCs to personalize the cures in the light of the precision medicine concept. Our main aim is to translate the scarce evidence from the literature into daily clinical practice, never forgetting that all the clinicians dedicated to rare GCs should encourage such patients’ enrolment in clinical trials and promote international collaborations. Hence, we focused on the treatment of the following rare GCs: rare gastric adenocarcinomas (hepatoid adenocarcinoma, medullary carcinoma with lymphoid stroma, Paneth cell carcinoma and Salivary Gland carcinoma); squamous cell carcinoma; adenosquamous carcinoma; neuroendocrine gastric neoplasms; gastroblastoma. |
| format | Article |
| id | doaj-art-5cdbb7cf832a4c6cb8d1caeab69ff716 |
| institution | Kabale University |
| issn | 1758-8359 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Medical Oncology |
| spelling | doaj-art-5cdbb7cf832a4c6cb8d1caeab69ff7162025-01-25T10:03:28ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592025-01-011710.1177/17588359241255628Rare epithelial gastric cancers: a review of the current treatment knowledgeAngelica PetrilloMargaret OttavianoLuca PompellaEmilio Francesco GiuntaPasquale PisapiaGianpaolo MarteAndrea TufoSara Di LorenzoJessica OreficeChiara MiceliUmberto MalapelleBruno DanieleFerdinando De VitaGastric cancer (GC), one of the tumours with the highest mortality worldwide, is not a homogeneous disease, showing different features according to location, macroscopic aspect, histotype and molecular alterations. Adenocarcinoma is the most frequent epithelial GC (95%), the remaining 5% comprising rare epithelial tumours with their peculiarities, behaviour and incidence <6 cases/100,000/year. Due to the low number of cases, many aspects must be elucidated in this context. In this narrative review, we highlight the importance of a better understanding of rare GCs to personalize the cures in the light of the precision medicine concept. Our main aim is to translate the scarce evidence from the literature into daily clinical practice, never forgetting that all the clinicians dedicated to rare GCs should encourage such patients’ enrolment in clinical trials and promote international collaborations. Hence, we focused on the treatment of the following rare GCs: rare gastric adenocarcinomas (hepatoid adenocarcinoma, medullary carcinoma with lymphoid stroma, Paneth cell carcinoma and Salivary Gland carcinoma); squamous cell carcinoma; adenosquamous carcinoma; neuroendocrine gastric neoplasms; gastroblastoma.https://doi.org/10.1177/17588359241255628 |
| spellingShingle | Angelica Petrillo Margaret Ottaviano Luca Pompella Emilio Francesco Giunta Pasquale Pisapia Gianpaolo Marte Andrea Tufo Sara Di Lorenzo Jessica Orefice Chiara Miceli Umberto Malapelle Bruno Daniele Ferdinando De Vita Rare epithelial gastric cancers: a review of the current treatment knowledge Therapeutic Advances in Medical Oncology |
| title | Rare epithelial gastric cancers: a review of the current treatment knowledge |
| title_full | Rare epithelial gastric cancers: a review of the current treatment knowledge |
| title_fullStr | Rare epithelial gastric cancers: a review of the current treatment knowledge |
| title_full_unstemmed | Rare epithelial gastric cancers: a review of the current treatment knowledge |
| title_short | Rare epithelial gastric cancers: a review of the current treatment knowledge |
| title_sort | rare epithelial gastric cancers a review of the current treatment knowledge |
| url | https://doi.org/10.1177/17588359241255628 |
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