Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma?
Th17/IL-17 plays an important role in host defense and hyperimmune responses against pathogenic bacteria accompanied by the recruitment of neutrophils. Th17-associated immune response is also involved in the pathogenesis of asthma, which is known as a noninfectious allergic airway disease and has be...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/6470364 |
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| _version_ | 1849413176513265664 |
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| author | Xu Yang Yunqiu Jiang Changzheng Wang |
| author_facet | Xu Yang Yunqiu Jiang Changzheng Wang |
| author_sort | Xu Yang |
| collection | DOAJ |
| description | Th17/IL-17 plays an important role in host defense and hyperimmune responses against pathogenic bacteria accompanied by the recruitment of neutrophils. Th17-associated immune response is also involved in the pathogenesis of asthma, which is known as a noninfectious allergic airway disease and has been shown to be heterogeneous. Th17-associated inflammation usually contributes to the neutrophilic phenotype, which is often characterized by greater severity, airflow obstruction, and steroid resistance. Concurrently, advanced culture-independent molecular techniques have increased our understanding of the lung microbiome and demonstrated that disorders of the lung microbiome, including changes of the total burden, diversity, and community composition, may contribute to severe, treatment-resistant neutrophilic asthma, although the precise mechanism is still unclear. Because Th17/IL-17 plays a role in bacteria-mediated immune responses and is involved in neutrophilic asthma, there may be a link between them. We review the effects of Th17/IL-17 on bacteria and asthma, showing the possibility that Th17/IL-17 may be a key player in neutrophilic asthma which may be characterized as severe or treatment-resistant by responding to the disordered lung microbiome. |
| format | Article |
| id | doaj-art-5cdb168b8a444223be905dc514d2ecc4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5cdb168b8a444223be905dc514d2ecc42025-08-20T03:34:13ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/64703646470364Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma?Xu Yang0Yunqiu Jiang1Changzheng Wang2Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaTh17/IL-17 plays an important role in host defense and hyperimmune responses against pathogenic bacteria accompanied by the recruitment of neutrophils. Th17-associated immune response is also involved in the pathogenesis of asthma, which is known as a noninfectious allergic airway disease and has been shown to be heterogeneous. Th17-associated inflammation usually contributes to the neutrophilic phenotype, which is often characterized by greater severity, airflow obstruction, and steroid resistance. Concurrently, advanced culture-independent molecular techniques have increased our understanding of the lung microbiome and demonstrated that disorders of the lung microbiome, including changes of the total burden, diversity, and community composition, may contribute to severe, treatment-resistant neutrophilic asthma, although the precise mechanism is still unclear. Because Th17/IL-17 plays a role in bacteria-mediated immune responses and is involved in neutrophilic asthma, there may be a link between them. We review the effects of Th17/IL-17 on bacteria and asthma, showing the possibility that Th17/IL-17 may be a key player in neutrophilic asthma which may be characterized as severe or treatment-resistant by responding to the disordered lung microbiome.http://dx.doi.org/10.1155/2016/6470364 |
| spellingShingle | Xu Yang Yunqiu Jiang Changzheng Wang Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma? Mediators of Inflammation |
| title | Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma? |
| title_full | Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma? |
| title_fullStr | Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma? |
| title_full_unstemmed | Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma? |
| title_short | Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma? |
| title_sort | does il 17 respond to the disordered lung microbiome and contribute to the neutrophilic phenotype in asthma |
| url | http://dx.doi.org/10.1155/2016/6470364 |
| work_keys_str_mv | AT xuyang doesil17respondtothedisorderedlungmicrobiomeandcontributetotheneutrophilicphenotypeinasthma AT yunqiujiang doesil17respondtothedisorderedlungmicrobiomeandcontributetotheneutrophilicphenotypeinasthma AT changzhengwang doesil17respondtothedisorderedlungmicrobiomeandcontributetotheneutrophilicphenotypeinasthma |