Revealing the impact of Pseudomonas aeruginosa quorum sensing molecule 2’-aminoacetophenone on the human bronchial-airway epithelium and pulmonary endothelium using a human airway-on-a-chip

Revealing the impact of Pseudomonas aeruginosa quorum sensing molecule 2’-aminoacetophenone on the human bronchial-airway epithelium and pulmonary endothelium using a human airway-on-a-chip

BackgroundPseudomonas aeruginosa (PA) causes severe respiratory infections utilizing multiple virulence functions. Previous findings on the PA secreted quorum sensing (QS)-regulated small molecule, 2’-aminoacetophenone (2-AA), revealed its impact on immune and metabolic functions, favouring a long-t...

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Bibliographic Details
Main Authors: Shifu Aggarwal, Arijit Chakraborty, Vijay K. Singh, Stephen Lory, Katia Karalis, Laurence G. Rahme
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Pseudomonas aeruginosa
2-aminoacetophenone
mvfR
pqsR
MvfR/pqsABCDE system
airway-on-a-chip
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592597/full
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