Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

Abstract Aberrant localization of proteins to mitochondria disturbs mitochondrial function and contributes to the pathogenesis of Huntington’s disease (HD). However, the crucial factors and the molecular mechanisms remain elusive. Here, we found that heat shock transcription factor 1 (HSF1) accumula...

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Main Authors: Chunyue Liu, Zixing Fu, Shanshan Wu, Xiaosong Wang, Shengrong Zhang, Chu Chu, Yuan Hong, Wenbo Wu, Shengqi Chen, Yueqing Jiang, Yang Wu, Yongbo Song, Yan Liu, Xing Guo
Format: Article
Language:English
Published: Springer Nature 2022-06-01
Series:EMBO Molecular Medicine
Subjects:
heat shock transcription factor 1
human striatal organoids
Huntington's disease
mitochondrial DNA
single‐stranded DNA‐binding protein 1
Online Access:https://doi.org/10.15252/emmm.202215851
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