The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade
Environmental exposures are ubiquitous and play a significant, and sometimes understated, role in public health as they can lead to the development of various chronic and infectious diseases. In an ideal world, there would be sufficient experimental data to determine the health effects of exposure t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/12/11/811 |
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| author | Siddhi Desai Jewell Wilson Chao Ji Jason Sautner Andrew J. Prussia Eugene Demchuk M. Moiz Mumtaz Patricia Ruiz |
| author_facet | Siddhi Desai Jewell Wilson Chao Ji Jason Sautner Andrew J. Prussia Eugene Demchuk M. Moiz Mumtaz Patricia Ruiz |
| author_sort | Siddhi Desai |
| collection | DOAJ |
| description | Environmental exposures are ubiquitous and play a significant, and sometimes understated, role in public health as they can lead to the development of various chronic and infectious diseases. In an ideal world, there would be sufficient experimental data to determine the health effects of exposure to priority environmental contaminants. However, this is not the case, as emerging chemicals are continuously added to this list, furthering the data gaps. Recently, simulation science has evolved and can provide appropriate solutions using a multitude of computational methods and tools. In its quest to protect communities across the country from environmental health threats, ATSDR employs a variety of simulation science tools such as Physiologically Based Pharmacokinetic (PBPK) modeling, Quantitative Structure–Activity Relationship (QSAR) modeling, and benchmark dose (BMD) modeling, among others. ATSDR’s use of such tools has enabled the agency to evaluate exposures in a timely, efficient, and effective manner. ATSDR’s work in simulation science has also had a notable impact beyond the agency, as evidenced by external researchers’ widespread appraisal and adaptation of the agency’s methodology. ATSDR continues to advance simulation science tools and their applications by collaborating with researchers within and outside the agency, including other federal/state agencies, NGOs, the private sector, and academia. |
| format | Article |
| id | doaj-art-5ccb9d3662a746d09b9caf840b7c0999 |
| institution | Kabale University |
| issn | 2305-6304 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj-art-5ccb9d3662a746d09b9caf840b7c09992024-11-26T18:23:53ZengMDPI AGToxics2305-63042024-11-01121181110.3390/toxics12110811The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last DecadeSiddhi Desai0Jewell Wilson1Chao Ji2Jason Sautner3Andrew J. Prussia4Eugene Demchuk5M. Moiz Mumtaz6Patricia Ruiz7Oak Ridge Institute for Science and Education, Oak Ridge, TN 37830, USAOffice of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30329, USAOffice of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30329, USAOffice of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30329, USAOffice of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30329, USAOffice of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30329, USAOffice of Associate Director for Science, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30329, USAOffice of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30329, USAEnvironmental exposures are ubiquitous and play a significant, and sometimes understated, role in public health as they can lead to the development of various chronic and infectious diseases. In an ideal world, there would be sufficient experimental data to determine the health effects of exposure to priority environmental contaminants. However, this is not the case, as emerging chemicals are continuously added to this list, furthering the data gaps. Recently, simulation science has evolved and can provide appropriate solutions using a multitude of computational methods and tools. In its quest to protect communities across the country from environmental health threats, ATSDR employs a variety of simulation science tools such as Physiologically Based Pharmacokinetic (PBPK) modeling, Quantitative Structure–Activity Relationship (QSAR) modeling, and benchmark dose (BMD) modeling, among others. ATSDR’s use of such tools has enabled the agency to evaluate exposures in a timely, efficient, and effective manner. ATSDR’s work in simulation science has also had a notable impact beyond the agency, as evidenced by external researchers’ widespread appraisal and adaptation of the agency’s methodology. ATSDR continues to advance simulation science tools and their applications by collaborating with researchers within and outside the agency, including other federal/state agencies, NGOs, the private sector, and academia.https://www.mdpi.com/2305-6304/12/11/811computational toxicologyPBPKQSARBMDfate and transport modelingmachine learning modeling |
| spellingShingle | Siddhi Desai Jewell Wilson Chao Ji Jason Sautner Andrew J. Prussia Eugene Demchuk M. Moiz Mumtaz Patricia Ruiz The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade Toxics computational toxicology PBPK QSAR BMD fate and transport modeling machine learning modeling |
| title | The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade |
| title_full | The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade |
| title_fullStr | The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade |
| title_full_unstemmed | The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade |
| title_short | The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade |
| title_sort | role of simulation science in public health at the agency for toxic substances and disease registry an overview and analysis of the last decade |
| topic | computational toxicology PBPK QSAR BMD fate and transport modeling machine learning modeling |
| url | https://www.mdpi.com/2305-6304/12/11/811 |
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