BCL11A-deficient human erythropoiesis is impaired in vitro and after xenotransplantation into mice

BCL11A-deficient human erythropoiesis is impaired in vitro and after xenotransplantation into mice

Abstract: Genetic depletion of the transcriptional repressor BCL11A in red blood cell precursors alleviates β-hemoglobinopathies by inducing the fetal γ-globin genes. However, additional erythroid genes are regulated by BCL11A and the effects of its deficiency on erythropoiesis are insufficiently de...

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Main Authors: Yoonjeong Jang, Ruopeng Feng, Lance E. Palmer, Thiyagaraj Mayuranathan, Yu Yao, Kalin Mayberry, Sheng Zhou, Jian Xu, Jeffrey M. Gossett, Guolian Kang, Yong Cheng, Jonathan S. Yen, Mitchell J. Weiss
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925001338
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