Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis Spectrophotometry
It has been proposed that the metal-drug complexes could be in fact the active agents displaying therapeutic effects of drugs. The characterization of the global formation equilibrium of complexes formed between metal ions and species with biological activity such as nonsteroidal anti-inflammatory d...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/9804162 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551672848580608 |
|---|---|
| author | Norma Rodríguez-Laguna Luis I. Reyes-García Rosario Moya-Hernández Alberto Rojas-Hernández Rodolfo Gómez-Balderas |
| author_facet | Norma Rodríguez-Laguna Luis I. Reyes-García Rosario Moya-Hernández Alberto Rojas-Hernández Rodolfo Gómez-Balderas |
| author_sort | Norma Rodríguez-Laguna |
| collection | DOAJ |
| description | It has been proposed that the metal-drug complexes could be in fact the active agents displaying therapeutic effects of drugs. The characterization of the global formation equilibrium of complexes formed between metal ions and species with biological activity such as nonsteroidal anti-inflammatory drugs provides essential information to understand the mechanism of action of drugs. Since equilibrium constants determine the relative predominance of species, they provide crucial information to identify what complexes are more likely to be present in the system being responsible for the therapeutic effects of the drug. In this paper, the systems formed between copper and Indomethacin of different concentrations in ethanol or water were studied by UV-Vis spectrophotometry. The stoichiometry of the complexes Cu(II)–Indomethacin and their formation constants were investigated. Moreover, molecular structures of the Cu(II)–Indomethacin complexes were explored by means of the molecular modeling within the frame of the density functional theory. |
| format | Article |
| id | doaj-art-5cca1f18d1514a15abe671c00652dfd2 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-5cca1f18d1514a15abe671c00652dfd22025-02-03T06:00:53ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/98041629804162Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis SpectrophotometryNorma Rodríguez-Laguna0Luis I. Reyes-García1Rosario Moya-Hernández2Alberto Rojas-Hernández3Rodolfo Gómez-Balderas4Laboratorio de Fisicoquímica Analítica, Unidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores-Cuautitlán, Universidad Nacional Autónoma de México, Carretera Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, 54714 Cuautitlán Izcalli, MEX, MexicoLaboratorio de Fisicoquímica Analítica, Unidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores-Cuautitlán, Universidad Nacional Autónoma de México, Carretera Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, 54714 Cuautitlán Izcalli, MEX, MexicoLaboratorio de Fisicoquímica Analítica, Unidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores-Cuautitlán, Universidad Nacional Autónoma de México, Carretera Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, 54714 Cuautitlán Izcalli, MEX, MexicoLaboratorio R-105/R-107, Área de Química Analítica, Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, Avenida San Rafael Atlixco 186, Colonia Vicentina, 09340 México, DF, MexicoLaboratorio de Fisicoquímica Analítica, Unidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores-Cuautitlán, Universidad Nacional Autónoma de México, Carretera Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, 54714 Cuautitlán Izcalli, MEX, MexicoIt has been proposed that the metal-drug complexes could be in fact the active agents displaying therapeutic effects of drugs. The characterization of the global formation equilibrium of complexes formed between metal ions and species with biological activity such as nonsteroidal anti-inflammatory drugs provides essential information to understand the mechanism of action of drugs. Since equilibrium constants determine the relative predominance of species, they provide crucial information to identify what complexes are more likely to be present in the system being responsible for the therapeutic effects of the drug. In this paper, the systems formed between copper and Indomethacin of different concentrations in ethanol or water were studied by UV-Vis spectrophotometry. The stoichiometry of the complexes Cu(II)–Indomethacin and their formation constants were investigated. Moreover, molecular structures of the Cu(II)–Indomethacin complexes were explored by means of the molecular modeling within the frame of the density functional theory.http://dx.doi.org/10.1155/2016/9804162 |
| spellingShingle | Norma Rodríguez-Laguna Luis I. Reyes-García Rosario Moya-Hernández Alberto Rojas-Hernández Rodolfo Gómez-Balderas Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis Spectrophotometry Journal of Chemistry |
| title | Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis Spectrophotometry |
| title_full | Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis Spectrophotometry |
| title_fullStr | Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis Spectrophotometry |
| title_full_unstemmed | Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis Spectrophotometry |
| title_short | Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis Spectrophotometry |
| title_sort | chemical speciation of the system cu ii indomethacin in ethanol and water by uv vis spectrophotometry |
| url | http://dx.doi.org/10.1155/2016/9804162 |
| work_keys_str_mv | AT normarodriguezlaguna chemicalspeciationofthesystemcuiiindomethacininethanolandwaterbyuvvisspectrophotometry AT luisireyesgarcia chemicalspeciationofthesystemcuiiindomethacininethanolandwaterbyuvvisspectrophotometry AT rosariomoyahernandez chemicalspeciationofthesystemcuiiindomethacininethanolandwaterbyuvvisspectrophotometry AT albertorojashernandez chemicalspeciationofthesystemcuiiindomethacininethanolandwaterbyuvvisspectrophotometry AT rodolfogomezbalderas chemicalspeciationofthesystemcuiiindomethacininethanolandwaterbyuvvisspectrophotometry |