Ethnobotany, phytochemistry, pharmacology and toxicity of Hagenia abyssinica (Bruce) J.F.Gmel.: a review
Hagenia abyssinica: (Bruce) J.F.Gmel. (H. abyssinica), commonly known as “kosso,” is a prevalent phytomedicine addressing aliments across Ethiopia. Traditionally, it is used to treat fever, abdominal pain, respiratory illnesses, intestinal parasitic infections, wound healing, and cancer. Current res...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1593724/full |
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| author | Guohui Shi Guohui Shi Linlin Ni Yang Zhang Zhizi Qu Xiaoni Kong Honglei Zhou Yan Xu |
| author_facet | Guohui Shi Guohui Shi Linlin Ni Yang Zhang Zhizi Qu Xiaoni Kong Honglei Zhou Yan Xu |
| author_sort | Guohui Shi |
| collection | DOAJ |
| description | Hagenia abyssinica: (Bruce) J.F.Gmel. (H. abyssinica), commonly known as “kosso,” is a prevalent phytomedicine addressing aliments across Ethiopia. Traditionally, it is used to treat fever, abdominal pain, respiratory illnesses, intestinal parasitic infections, wound healing, and cancer. Current research has revealed its anthelmintic, antimicrobial, antihyperglycemic, antidyslipidemic, antidiarrheal, and antioxidant activities. These pharmacological properties might be attributed to the presence of secondary metabolites, such as terpenoids, flavonoids, and phenols. Its crude extract is safe in vivo at doses less than 2,000 mg/kg, but larger doses can cause damage to the optic nerve. Although significant research findings are available, challenges remain. This paper provides a comprehensive review of research findings, identifying gaps in mechanistic studies and standardized toxicology assessments. Future priorities include applying ConPhyMP guidelines for extract characterization and integrating traditional knowledge with biodiversity conservation. |
| format | Article |
| id | doaj-art-5cc5e6aa7a894a5492a298fdc7aee8a0 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-5cc5e6aa7a894a5492a298fdc7aee8a02025-08-20T02:22:01ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.15937241593724Ethnobotany, phytochemistry, pharmacology and toxicity of Hagenia abyssinica (Bruce) J.F.Gmel.: a reviewGuohui Shi0Guohui Shi1Linlin Ni2Yang Zhang3Zhizi Qu4Xiaoni Kong5Honglei Zhou6Yan Xu7Medical School, Shandong Xiehe University, Jinan, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaThe Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Pharmacy, Shandong College of Traditional Chinese Medicine, Yantai, Shandong, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaMedical School, Shandong Xiehe University, Jinan, ChinaHagenia abyssinica: (Bruce) J.F.Gmel. (H. abyssinica), commonly known as “kosso,” is a prevalent phytomedicine addressing aliments across Ethiopia. Traditionally, it is used to treat fever, abdominal pain, respiratory illnesses, intestinal parasitic infections, wound healing, and cancer. Current research has revealed its anthelmintic, antimicrobial, antihyperglycemic, antidyslipidemic, antidiarrheal, and antioxidant activities. These pharmacological properties might be attributed to the presence of secondary metabolites, such as terpenoids, flavonoids, and phenols. Its crude extract is safe in vivo at doses less than 2,000 mg/kg, but larger doses can cause damage to the optic nerve. Although significant research findings are available, challenges remain. This paper provides a comprehensive review of research findings, identifying gaps in mechanistic studies and standardized toxicology assessments. Future priorities include applying ConPhyMP guidelines for extract characterization and integrating traditional knowledge with biodiversity conservation.https://www.frontiersin.org/articles/10.3389/fphar.2025.1593724/fullHagenia abyssinica (Bruce) J.F.Gmel.traditional usesphytochemistrypharmacologytoxicity |
| spellingShingle | Guohui Shi Guohui Shi Linlin Ni Yang Zhang Zhizi Qu Xiaoni Kong Honglei Zhou Yan Xu Ethnobotany, phytochemistry, pharmacology and toxicity of Hagenia abyssinica (Bruce) J.F.Gmel.: a review Frontiers in Pharmacology Hagenia abyssinica (Bruce) J.F.Gmel. traditional uses phytochemistry pharmacology toxicity |
| title | Ethnobotany, phytochemistry, pharmacology and toxicity of Hagenia abyssinica (Bruce) J.F.Gmel.: a review |
| title_full | Ethnobotany, phytochemistry, pharmacology and toxicity of Hagenia abyssinica (Bruce) J.F.Gmel.: a review |
| title_fullStr | Ethnobotany, phytochemistry, pharmacology and toxicity of Hagenia abyssinica (Bruce) J.F.Gmel.: a review |
| title_full_unstemmed | Ethnobotany, phytochemistry, pharmacology and toxicity of Hagenia abyssinica (Bruce) J.F.Gmel.: a review |
| title_short | Ethnobotany, phytochemistry, pharmacology and toxicity of Hagenia abyssinica (Bruce) J.F.Gmel.: a review |
| title_sort | ethnobotany phytochemistry pharmacology and toxicity of hagenia abyssinica bruce j f gmel a review |
| topic | Hagenia abyssinica (Bruce) J.F.Gmel. traditional uses phytochemistry pharmacology toxicity |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1593724/full |
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