Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D

Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D

Lagunamide D is a structurally distinct 26-membered cytotoxic cyclic depsipeptide, originally isolated from a marine cyanobacterium. It exhibits potent antiproliferative activity in the low nanomolar range against A549 human lung adenocarcinoma cells and HCT116 colon cancer cells. A significant chal...

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Bibliographic Details
Main Authors:	Huiru Nan, Xiong-En Long, Jianfei He, Hailiang Xing, Min-Jing Cheng, Jin-Bao Peng, Tao Ye, Jia-Lei Yan, Junyang Liu
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Series:	Marine Drugs
Subjects:	lagunamide D marine natural products depsipeptide total synthesis
Online Access:	https://www.mdpi.com/1660-3397/23/3/99
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