Testosterone Replacement Therapy Can Improve a Biomarker of Liver Fibrosis in Hypogonadal Men: A Subanalysis of a Prospective Randomized Controlled Study in Japan (EARTH Study)
Purpose: We investigated the effects of testosterone replacement therapy (TRT) on the Fibrosis-4 (FIB-4) index among hypogonadal patients who were extracted from a randomized controlled study in Japan (the EARTH study). Materials and Methods: Data of 186 patients (88 in the TRT group; 98 in the co...
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| Language: | English |
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Korean Society for Sexual Medicine and Andrology
2025-07-01
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| Series: | The World Journal of Men's Health |
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| author | Kazuyoshi Shigehara Yuki Kato Rei Shinzawa Hiroyuki Konaka Shohei Kawaguchi Takahiro Nohara Kouji Izumi Mikio Namiki Atsushi Mizokami |
| author_facet | Kazuyoshi Shigehara Yuki Kato Rei Shinzawa Hiroyuki Konaka Shohei Kawaguchi Takahiro Nohara Kouji Izumi Mikio Namiki Atsushi Mizokami |
| author_sort | Kazuyoshi Shigehara |
| collection | DOAJ |
| description | Purpose: We investigated the effects of testosterone replacement therapy (TRT) on the Fibrosis-4 (FIB-4) index among hypogonadal
patients who were extracted from a randomized controlled study in Japan (the EARTH study).
Materials and Methods: Data of 186 patients (88 in the TRT group; 98 in the control group) were collected. The patients in the
TRT group received intramuscular administration of testosterone enanthate (250 mg) every 4 weeks for 12 months. The patients’
background information such as current medical history and lifestyle habits were collected. Waist circumference, body mass
index, and body fat volume were measured at baseline and 12-month visit. Fasting blood sugar (FBS), hemoglobin A1c, total
cholesterol, triglyceride (TG), and high-density lipoprotein cholesterol levels were collected at baseline and 12-month visit. The
FIB-4 index was calculated according to age, aspartate aminotransferase, alanine transaminase, and platelet count.
Results: Except for serum FBS values, most of baseline characteristics were comparable between the TRT and control groups.
When comparing the changes of each variable from baseline at 12-month visit in both groups, significant differences were
found in waist circumference (p=0.00248), fat volume (p=0.00812), and platelet counts (p=0.0478), whereas a FIB-4 index
did not change. On the contrary, in a subanalysis including only patients with a FIB-4 index ≥1.30 at baseline, a significant
difference in a FIB-4 index (−0.10±0.39 vs. 0.04±0.44; p=0.0311) was observed with significant decreases in waist circumference,
body fat volume, and TG levels, and an increase in platelet counts. The FIB-4 index was significantly decreased by
TRT from 1.98±0.52 to 1.87±0.60 (p=0.0277).
Conclusions: TRT for 12 months improved the FIB-4 index among hypogonadal men with a higher baseline FIB-4 index. |
| format | Article |
| id | doaj-art-5cc46c32537e40a1bb1fec462ec6946d |
| institution | Kabale University |
| issn | 2287-4208 2287-4690 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj-art-5cc46c32537e40a1bb1fec462ec6946d2025-08-20T03:29:23ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902025-07-0143366166810.5534/wjmh.240066Testosterone Replacement Therapy Can Improve a Biomarker of Liver Fibrosis in Hypogonadal Men: A Subanalysis of a Prospective Randomized Controlled Study in Japan (EARTH Study)Kazuyoshi Shigehara0https://orcid.org/0000-0002-2118-9135Yuki Kato1https://orcid.org/0000-0002-1833-5381Rei Shinzawa2https://orcid.org/0009-0002-1781-2817Hiroyuki Konaka3https://orcid.org/0000-0002-6193-0274Shohei Kawaguchi4https://orcid.org/0000-0001-6847-9861Takahiro Nohara5https://orcid.org/0000-0001-9792-2068Kouji Izumi6https://orcid.org/0000-0002-8480-9100Mikio Namiki7https://orcid.org/0000-0002-0415-650XAtsushi Mizokami8https://orcid.org/0000-0002-5643-2182Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanDepartment of Urology, Kanazawa Red Cross Hospital, Kanazawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanDepartment of Urology, Hasegawa Hospital, Toyama, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: We investigated the effects of testosterone replacement therapy (TRT) on the Fibrosis-4 (FIB-4) index among hypogonadal patients who were extracted from a randomized controlled study in Japan (the EARTH study). Materials and Methods: Data of 186 patients (88 in the TRT group; 98 in the control group) were collected. The patients in the TRT group received intramuscular administration of testosterone enanthate (250 mg) every 4 weeks for 12 months. The patients’ background information such as current medical history and lifestyle habits were collected. Waist circumference, body mass index, and body fat volume were measured at baseline and 12-month visit. Fasting blood sugar (FBS), hemoglobin A1c, total cholesterol, triglyceride (TG), and high-density lipoprotein cholesterol levels were collected at baseline and 12-month visit. The FIB-4 index was calculated according to age, aspartate aminotransferase, alanine transaminase, and platelet count. Results: Except for serum FBS values, most of baseline characteristics were comparable between the TRT and control groups. When comparing the changes of each variable from baseline at 12-month visit in both groups, significant differences were found in waist circumference (p=0.00248), fat volume (p=0.00812), and platelet counts (p=0.0478), whereas a FIB-4 index did not change. On the contrary, in a subanalysis including only patients with a FIB-4 index ≥1.30 at baseline, a significant difference in a FIB-4 index (−0.10±0.39 vs. 0.04±0.44; p=0.0311) was observed with significant decreases in waist circumference, body fat volume, and TG levels, and an increase in platelet counts. The FIB-4 index was significantly decreased by TRT from 1.98±0.52 to 1.87±0.60 (p=0.0277). Conclusions: TRT for 12 months improved the FIB-4 index among hypogonadal men with a higher baseline FIB-4 index.fibrosishypogonadismliver cirrhosismetabolic syndrometestosterone |
| spellingShingle | Kazuyoshi Shigehara Yuki Kato Rei Shinzawa Hiroyuki Konaka Shohei Kawaguchi Takahiro Nohara Kouji Izumi Mikio Namiki Atsushi Mizokami Testosterone Replacement Therapy Can Improve a Biomarker of Liver Fibrosis in Hypogonadal Men: A Subanalysis of a Prospective Randomized Controlled Study in Japan (EARTH Study) The World Journal of Men's Health fibrosis hypogonadism liver cirrhosis metabolic syndrome testosterone |
| title | Testosterone Replacement Therapy Can Improve a Biomarker of Liver Fibrosis in Hypogonadal Men: A Subanalysis of a Prospective Randomized Controlled Study in Japan (EARTH Study) |
| title_full | Testosterone Replacement Therapy Can Improve a Biomarker of Liver Fibrosis in Hypogonadal Men: A Subanalysis of a Prospective Randomized Controlled Study in Japan (EARTH Study) |
| title_fullStr | Testosterone Replacement Therapy Can Improve a Biomarker of Liver Fibrosis in Hypogonadal Men: A Subanalysis of a Prospective Randomized Controlled Study in Japan (EARTH Study) |
| title_full_unstemmed | Testosterone Replacement Therapy Can Improve a Biomarker of Liver Fibrosis in Hypogonadal Men: A Subanalysis of a Prospective Randomized Controlled Study in Japan (EARTH Study) |
| title_short | Testosterone Replacement Therapy Can Improve a Biomarker of Liver Fibrosis in Hypogonadal Men: A Subanalysis of a Prospective Randomized Controlled Study in Japan (EARTH Study) |
| title_sort | testosterone replacement therapy can improve a biomarker of liver fibrosis in hypogonadal men a subanalysis of a prospective randomized controlled study in japan earth study |
| topic | fibrosis hypogonadism liver cirrhosis metabolic syndrome testosterone |
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