A PBPK modeling approach for personalized dose optimization of nicardipine in renal and hepatic dysfunction

A PBPK modeling approach for personalized dose optimization of nicardipine in renal and hepatic dysfunction

Abstract Nicardipine is a calcium channel blocker employed to manage hypertension and angina. It is primarily metabolized in the liver; therefore, hepatic impairment patients may experience drug accumulation, potentially resulting in adverse events. This research aims to design physiologically based...

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Bibliographic Details
Main Authors: Ammara Ayub, Ammara Zamir, Muhammad Fawad Rasool, Usman Arshad, Faleh Alqahtani
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Nicardipine
PBPK model
Hypertension
Liver cirrhosis
Renal impairment
Online Access:https://doi.org/10.1038/s41598-025-03829-4
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