Cold-inducible RNA-binding protein is associated with subtype-specific breast cancer patient outcomes
Abstract Background Cold-inducible RNA-binding protein (CIRBP) is a stress-induced mRNA-binding protein associated with clinical outcomes in a variety of human disease states. The role of CIRBP as a role as a prognostic biomarker in breast cancer (BC) has yet to be established. Findings We describe...
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BMC
2025-08-01
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| Series: | Breast Cancer Research |
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| Online Access: | https://doi.org/10.1186/s13058-025-02098-3 |
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| author | Matthew Dankner Veronique Ouellet Jakob Lafon Rima Ezzeddine Matthew G. Annis Afnan Abu-Thuraia Quebec Breast Cancer Foundation Tissue Microarray Consortium Peter M. Siegel |
| author_facet | Matthew Dankner Veronique Ouellet Jakob Lafon Rima Ezzeddine Matthew G. Annis Afnan Abu-Thuraia Quebec Breast Cancer Foundation Tissue Microarray Consortium Peter M. Siegel |
| author_sort | Matthew Dankner |
| collection | DOAJ |
| description | Abstract Background Cold-inducible RNA-binding protein (CIRBP) is a stress-induced mRNA-binding protein associated with clinical outcomes in a variety of human disease states. The role of CIRBP as a role as a prognostic biomarker in breast cancer (BC) has yet to be established. Findings We describe a clinically annotated tissue micro-array cohort of 1406 hormone receptor positive (HR +) and 281 triple negative primary breast cancers (TNBC) stained by immunohistochemistry (IHC) for CIRBP. Statistical analyses were performed with the Kaplan–Meier estimator, as well as univariate and multivariate Cox proportional-hazards models. Multivariate models incorporated tumor size, lymph node status, grade and CIRBP expression levels. Co-primary endpoints were overall survival (OS) and progression-free survival (PFS). In N = 281 primary TNBCs, high levels of CIRBP expression by IHC was associated with poor prognosis in multivariate analysis (OS: adjusted hazard ratio (aHR) 2.05, 95% confidence interval (CI) 1.24–3.41, P = 0.005. PFS: aHR 2.46, 95% CI 1.33–4.57, P = 0.004). However, in N = 1406 HR + primary BC, CIRBP expression was correlated with favorable prognosis (OS: aHR 0.927, 95% CI 0.88–0.98, P = 0.005. PFS: aHR 0.904, 95% CI 0.85–0.96, P = 0.002). Conclusions CIRBP expression is associated with poor prognosis in TNBC but not HR + BC patients. This finding highlights the prognostic significance of CIRBP in TNBC and suggests differential underlying mRNA targets bound and modulated by CIRBP in TNBC and HR + BC, respectively. |
| format | Article |
| id | doaj-art-5cc2e5d2da634ae899511f2ee10640c3 |
| institution | Kabale University |
| issn | 1465-542X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj-art-5cc2e5d2da634ae899511f2ee10640c32025-08-24T11:58:47ZengBMCBreast Cancer Research1465-542X2025-08-0127111710.1186/s13058-025-02098-3Cold-inducible RNA-binding protein is associated with subtype-specific breast cancer patient outcomesMatthew Dankner0Veronique Ouellet1Jakob Lafon2Rima Ezzeddine3Matthew G. Annis4Afnan Abu-Thuraia5Quebec Breast Cancer Foundation Tissue Microarray Consortium6Peter M. Siegel7Rosalind and Morris Goodman Cancer InstituteCentre de Recherche, Centre Hospitalier de L’Université de MontréalDepartment of Medicine, McGill UniversityRosalind and Morris Goodman Cancer InstituteRosalind and Morris Goodman Cancer InstituteRosalind and Morris Goodman Cancer InstituteQuébec Breast Cancer FoundationRosalind and Morris Goodman Cancer InstituteAbstract Background Cold-inducible RNA-binding protein (CIRBP) is a stress-induced mRNA-binding protein associated with clinical outcomes in a variety of human disease states. The role of CIRBP as a role as a prognostic biomarker in breast cancer (BC) has yet to be established. Findings We describe a clinically annotated tissue micro-array cohort of 1406 hormone receptor positive (HR +) and 281 triple negative primary breast cancers (TNBC) stained by immunohistochemistry (IHC) for CIRBP. Statistical analyses were performed with the Kaplan–Meier estimator, as well as univariate and multivariate Cox proportional-hazards models. Multivariate models incorporated tumor size, lymph node status, grade and CIRBP expression levels. Co-primary endpoints were overall survival (OS) and progression-free survival (PFS). In N = 281 primary TNBCs, high levels of CIRBP expression by IHC was associated with poor prognosis in multivariate analysis (OS: adjusted hazard ratio (aHR) 2.05, 95% confidence interval (CI) 1.24–3.41, P = 0.005. PFS: aHR 2.46, 95% CI 1.33–4.57, P = 0.004). However, in N = 1406 HR + primary BC, CIRBP expression was correlated with favorable prognosis (OS: aHR 0.927, 95% CI 0.88–0.98, P = 0.005. PFS: aHR 0.904, 95% CI 0.85–0.96, P = 0.002). Conclusions CIRBP expression is associated with poor prognosis in TNBC but not HR + BC patients. This finding highlights the prognostic significance of CIRBP in TNBC and suggests differential underlying mRNA targets bound and modulated by CIRBP in TNBC and HR + BC, respectively.https://doi.org/10.1186/s13058-025-02098-3CIRBPBreast cancerTNBCEstrogen receptorBiomarker |
| spellingShingle | Matthew Dankner Veronique Ouellet Jakob Lafon Rima Ezzeddine Matthew G. Annis Afnan Abu-Thuraia Quebec Breast Cancer Foundation Tissue Microarray Consortium Peter M. Siegel Cold-inducible RNA-binding protein is associated with subtype-specific breast cancer patient outcomes Breast Cancer Research CIRBP Breast cancer TNBC Estrogen receptor Biomarker |
| title | Cold-inducible RNA-binding protein is associated with subtype-specific breast cancer patient outcomes |
| title_full | Cold-inducible RNA-binding protein is associated with subtype-specific breast cancer patient outcomes |
| title_fullStr | Cold-inducible RNA-binding protein is associated with subtype-specific breast cancer patient outcomes |
| title_full_unstemmed | Cold-inducible RNA-binding protein is associated with subtype-specific breast cancer patient outcomes |
| title_short | Cold-inducible RNA-binding protein is associated with subtype-specific breast cancer patient outcomes |
| title_sort | cold inducible rna binding protein is associated with subtype specific breast cancer patient outcomes |
| topic | CIRBP Breast cancer TNBC Estrogen receptor Biomarker |
| url | https://doi.org/10.1186/s13058-025-02098-3 |
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