Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review
Cutaneous squamomelanocytic tumor (SMT) is a very rare cutaneous malignancy, composed of a dual phenotypic population of both malignant melanocytes and keratinocytes, intimately intermingled together. Herein, we report a new case of a SMT occurring in an 82-year-old man, located on the scalp. Histop...
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MDPI AG
2025-01-01
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| Series: | Dermatopathology |
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| Online Access: | https://www.mdpi.com/2296-3529/12/1/1 |
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| author | Joana Sorino Mario Della Mura Anna Colagrande Cecilia Salzillo Giuseppe Ingravallo Gerardo Cazzato |
| author_facet | Joana Sorino Mario Della Mura Anna Colagrande Cecilia Salzillo Giuseppe Ingravallo Gerardo Cazzato |
| author_sort | Joana Sorino |
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| description | Cutaneous squamomelanocytic tumor (SMT) is a very rare cutaneous malignancy, composed of a dual phenotypic population of both malignant melanocytes and keratinocytes, intimately intermingled together. Herein, we report a new case of a SMT occurring in an 82-year-old man, located on the scalp. Histopathology revealed a mixed population consisting of squamous cell carcinoma and melanoma within the same lesion, also confirmed using immunohistochemical staining for high molecular-weight cytokeratins (HMWCKs) and Melan-A. Moreover, to the best of our knowledge, for the first time, we tested SMT for the preferentially expressed antigen in melanoma (PRAME), which revealed a strong and diffuse positivity in the melanocytic component. These tumors need to be distinguished by more frequent collision tumors and colonization. Furthermore, we provide a comprehensive review of the literature, focusing on clinical and histopathological aspects, biological behavior and still-debated, but fascinating histogenesis of this elusive entity. |
| format | Article |
| id | doaj-art-5cbc88347d884dafa0616e58782a45fe |
| institution | OA Journals |
| issn | 2296-3529 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dermatopathology |
| spelling | doaj-art-5cbc88347d884dafa0616e58782a45fe2025-08-20T02:11:16ZengMDPI AGDermatopathology2296-35292025-01-01121110.3390/dermatopathology12010001Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature ReviewJoana Sorino0Mario Della Mura1Anna Colagrande2Cecilia Salzillo3Giuseppe Ingravallo4Gerardo Cazzato5Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalyCutaneous squamomelanocytic tumor (SMT) is a very rare cutaneous malignancy, composed of a dual phenotypic population of both malignant melanocytes and keratinocytes, intimately intermingled together. Herein, we report a new case of a SMT occurring in an 82-year-old man, located on the scalp. Histopathology revealed a mixed population consisting of squamous cell carcinoma and melanoma within the same lesion, also confirmed using immunohistochemical staining for high molecular-weight cytokeratins (HMWCKs) and Melan-A. Moreover, to the best of our knowledge, for the first time, we tested SMT for the preferentially expressed antigen in melanoma (PRAME), which revealed a strong and diffuse positivity in the melanocytic component. These tumors need to be distinguished by more frequent collision tumors and colonization. Furthermore, we provide a comprehensive review of the literature, focusing on clinical and histopathological aspects, biological behavior and still-debated, but fascinating histogenesis of this elusive entity.https://www.mdpi.com/2296-3529/12/1/1squamomelanocytic tumormelanomasquamous cell carcinomamelanocarcinomacollisioncombined |
| spellingShingle | Joana Sorino Mario Della Mura Anna Colagrande Cecilia Salzillo Giuseppe Ingravallo Gerardo Cazzato Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review Dermatopathology squamomelanocytic tumor melanoma squamous cell carcinoma melanocarcinoma collision combined |
| title | Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review |
| title_full | Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review |
| title_fullStr | Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review |
| title_full_unstemmed | Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review |
| title_short | Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review |
| title_sort | squamomelanocytic tumor an entity still shrouded in mystery case report and literature review |
| topic | squamomelanocytic tumor melanoma squamous cell carcinoma melanocarcinoma collision combined |
| url | https://www.mdpi.com/2296-3529/12/1/1 |
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