Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review
Abstract Exposure to air pollutants has a direct impact on human health, resulting in increased mortality rates. Airborne particulate matter (PM) has major adverse effects on health and can be classified as high-risk respiratory particles (fine/PM2.5, aerodynamic diameter < 2.5 µm) or thoracic pa...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-03-01
|
| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-025-03179-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849392233390800896 |
|---|---|
| author | Sonia Arca-Lafuente Beatriz Nuñez-Corcuera Rebeca Ramis Spyros Karakitsios Denis Sarigiannis Saúl García Dos Santos Amanda Fernández-Rodríguez Verónica Briz |
| author_facet | Sonia Arca-Lafuente Beatriz Nuñez-Corcuera Rebeca Ramis Spyros Karakitsios Denis Sarigiannis Saúl García Dos Santos Amanda Fernández-Rodríguez Verónica Briz |
| author_sort | Sonia Arca-Lafuente |
| collection | DOAJ |
| description | Abstract Exposure to air pollutants has a direct impact on human health, resulting in increased mortality rates. Airborne particulate matter (PM) has major adverse effects on health and can be classified as high-risk respiratory particles (fine/PM2.5, aerodynamic diameter < 2.5 µm) or thoracic particles (coarse/PM10, aerodynamic diameter < 10 µm). In addition, airborne PM can carry microbial communities that alter the commensal microbiota and lead to dysbiosis. Our aim was to synthesize the current research evidence describing the association between air pollution exposure and the microbiome composition of the upper respiratory tract (URT) of the adult population. In this work, a systematic search of the PubMed, EMBASE and Scopus databases was conducted. A total of 9 studies published from 2018 to 2023 were included. 66.5% of the participants were exposed to PM2.5 concentrations higher than 40 µg/m3, and data showed that PM2.5 atmospheric levels were positively correlated with PM10 (rs = 0.95, p < 0.001). All the reviewed studies performed 16S rRNA sequencing of the V3–V4 region from URT samples, using different methods. Overall, evidence of URT microbiome alterations after high PM exposure was observed, with seasonal and geographical influence. Discordant findings were found about bacterial diversity, with a predominant decrease after exposure to high PM levels. Regarding microbiome composition, the relative abundance of the Actinobacteria phylum declined following exposure to high levels of PM, but that of Bacteroidetes and Fusobacteria increased. The studies showed a low-middle risk of bias due to heterogeneity regarding sample processing, sequencing methods, and confounder control. To confirm the observed evidence of an association between PM levels and alterations in the URT microbiome, we strongly recommend that future research work be conducted in accordance with standard guidelines for reporting microbiome studies. In summary, the entry of fine and coarse particles into the URT is associated with microbial dysbiosis, increasing the risk of developing respiratory diseases and allergies. Prospero registration: This systematic review was registered on PROSPERO (#CRD42023416230) Graphical Abstract |
| format | Article |
| id | doaj-art-5cbc5191cdb8492ab80490e8e4ffdf3a |
| institution | Kabale University |
| issn | 1465-993X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj-art-5cbc5191cdb8492ab80490e8e4ffdf3a2025-08-20T03:40:48ZengBMCRespiratory Research1465-993X2025-03-0126111810.1186/s12931-025-03179-9Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic reviewSonia Arca-Lafuente0Beatriz Nuñez-Corcuera1Rebeca Ramis2Spyros Karakitsios3Denis Sarigiannis4Saúl García Dos Santos5Amanda Fernández-Rodríguez6Verónica Briz7Viral Hepatitis Reference and Research Laboratory, National Center of Microbiology, Institute of Health Carlos IIIAir Pollution Area, National Center for Environmental Health. Institute of Health Carlos III (ISCIII)Cancer and Environmental Epidemiology Unit. Chronic Diseases Department, National Centre for Epidemiology, Institute of Health Carlos III (ISCIII)Laboratory of Environmental Engineering (Enve-Lab), Aristotle University of Thessaloniki, Department of Chemical EngineeringLaboratory of Environmental Engineering (Enve-Lab), Aristotle University of Thessaloniki, Department of Chemical EngineeringAir Pollution Area, National Center for Environmental Health. Institute of Health Carlos III (ISCIII)Viral Hepatitis Reference and Research Laboratory, National Center of Microbiology, Institute of Health Carlos IIIViral Hepatitis Reference and Research Laboratory, National Center of Microbiology, Institute of Health Carlos IIIAbstract Exposure to air pollutants has a direct impact on human health, resulting in increased mortality rates. Airborne particulate matter (PM) has major adverse effects on health and can be classified as high-risk respiratory particles (fine/PM2.5, aerodynamic diameter < 2.5 µm) or thoracic particles (coarse/PM10, aerodynamic diameter < 10 µm). In addition, airborne PM can carry microbial communities that alter the commensal microbiota and lead to dysbiosis. Our aim was to synthesize the current research evidence describing the association between air pollution exposure and the microbiome composition of the upper respiratory tract (URT) of the adult population. In this work, a systematic search of the PubMed, EMBASE and Scopus databases was conducted. A total of 9 studies published from 2018 to 2023 were included. 66.5% of the participants were exposed to PM2.5 concentrations higher than 40 µg/m3, and data showed that PM2.5 atmospheric levels were positively correlated with PM10 (rs = 0.95, p < 0.001). All the reviewed studies performed 16S rRNA sequencing of the V3–V4 region from URT samples, using different methods. Overall, evidence of URT microbiome alterations after high PM exposure was observed, with seasonal and geographical influence. Discordant findings were found about bacterial diversity, with a predominant decrease after exposure to high PM levels. Regarding microbiome composition, the relative abundance of the Actinobacteria phylum declined following exposure to high levels of PM, but that of Bacteroidetes and Fusobacteria increased. The studies showed a low-middle risk of bias due to heterogeneity regarding sample processing, sequencing methods, and confounder control. To confirm the observed evidence of an association between PM levels and alterations in the URT microbiome, we strongly recommend that future research work be conducted in accordance with standard guidelines for reporting microbiome studies. In summary, the entry of fine and coarse particles into the URT is associated with microbial dysbiosis, increasing the risk of developing respiratory diseases and allergies. Prospero registration: This systematic review was registered on PROSPERO (#CRD42023416230) Graphical Abstracthttps://doi.org/10.1186/s12931-025-03179-9PM2.5PM10MicrobiomeDysbiosisUpper respiratory tract |
| spellingShingle | Sonia Arca-Lafuente Beatriz Nuñez-Corcuera Rebeca Ramis Spyros Karakitsios Denis Sarigiannis Saúl García Dos Santos Amanda Fernández-Rodríguez Verónica Briz Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review Respiratory Research PM2.5 PM10 Microbiome Dysbiosis Upper respiratory tract |
| title | Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review |
| title_full | Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review |
| title_fullStr | Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review |
| title_full_unstemmed | Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review |
| title_short | Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review |
| title_sort | effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome a systematic review |
| topic | PM2.5 PM10 Microbiome Dysbiosis Upper respiratory tract |
| url | https://doi.org/10.1186/s12931-025-03179-9 |
| work_keys_str_mv | AT soniaarcalafuente effectsofurbanairborneparticulatematterexposureonthehumanupperrespiratorytractmicrobiomeasystematicreview AT beatriznunezcorcuera effectsofurbanairborneparticulatematterexposureonthehumanupperrespiratorytractmicrobiomeasystematicreview AT rebecaramis effectsofurbanairborneparticulatematterexposureonthehumanupperrespiratorytractmicrobiomeasystematicreview AT spyroskarakitsios effectsofurbanairborneparticulatematterexposureonthehumanupperrespiratorytractmicrobiomeasystematicreview AT denissarigiannis effectsofurbanairborneparticulatematterexposureonthehumanupperrespiratorytractmicrobiomeasystematicreview AT saulgarciadossantos effectsofurbanairborneparticulatematterexposureonthehumanupperrespiratorytractmicrobiomeasystematicreview AT amandafernandezrodriguez effectsofurbanairborneparticulatematterexposureonthehumanupperrespiratorytractmicrobiomeasystematicreview AT veronicabriz effectsofurbanairborneparticulatematterexposureonthehumanupperrespiratorytractmicrobiomeasystematicreview |