A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus
Type 1 diabetes mellitus (T1DM) has been inconsistently associated with low bone mineral density (BMD) and increased fracture risk. 86 consecutive T1DM cases and 140 unrelated age and sex matched healthy nondiabetic controls were included in the study. After history and examination, BMD and body com...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2013/397814 |
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| author | Ameya Joshi Premlata Varthakavi Manoj Chadha Nikhil Bhagwat |
| author_facet | Ameya Joshi Premlata Varthakavi Manoj Chadha Nikhil Bhagwat |
| author_sort | Ameya Joshi |
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| description | Type 1 diabetes mellitus (T1DM) has been inconsistently associated with low bone mineral density (BMD) and increased fracture risk. 86 consecutive T1DM cases and 140 unrelated age and sex matched healthy nondiabetic controls were included in the study. After history and examination, BMD and body composition were assessed by dual energy X-ray absorptiometry (DXA). Serum samples were analyzed for calcium, phosphorus, albumin, creatinine, alkaline phosphatase, 25 (OH) vitamin D3, intact parathormone (PTH) levels (both cases and controls) and HbA1c, antimicrosomal and IgA tissue transglutaminase (IgA TTG) antibodies, cortisol, follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG), tetraiodothyronine (T4), thyroid stimulating hormone (TSH), growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP3) (cases only). T1DM cases had a lower BMD as compared to controls at both total body (TB) and lumbar spine (LS) (). Patients with celiac autoimmunity (CA) had significantly, lower BMD as compared to age, sex, and body mass index (BMI) matched T1DM controls. Linear regression analysis showed that low BMD in T1DM patients was associated with poor glycaemic control, lower IGF-1 levels, less physical activity (in total population as well as in male and female subgroups), and lower body fat percentage (in females) and higher alkaline phosphatase level (in males) (). |
| format | Article |
| id | doaj-art-5cbadd7c1c44425883afaeeec025f1ed |
| institution | OA Journals |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | Journal of Osteoporosis |
| spelling | doaj-art-5cbadd7c1c44425883afaeeec025f1ed2025-08-20T02:04:59ZengWileyJournal of Osteoporosis2090-80592042-00642013-01-01201310.1155/2013/397814397814A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes MellitusAmeya Joshi0Premlata Varthakavi1Manoj Chadha2Nikhil Bhagwat3Departmnent of Endocrinology, Topiwala National Medical College & BYL Nair Hospital, Mumbai 400008, IndiaDepartmnent of Endocrinology, Topiwala National Medical College & BYL Nair Hospital, Mumbai 400008, IndiaDepartmnent of Endocrinology, Topiwala National Medical College & BYL Nair Hospital, Mumbai 400008, IndiaDepartmnent of Endocrinology, Topiwala National Medical College & BYL Nair Hospital, Mumbai 400008, IndiaType 1 diabetes mellitus (T1DM) has been inconsistently associated with low bone mineral density (BMD) and increased fracture risk. 86 consecutive T1DM cases and 140 unrelated age and sex matched healthy nondiabetic controls were included in the study. After history and examination, BMD and body composition were assessed by dual energy X-ray absorptiometry (DXA). Serum samples were analyzed for calcium, phosphorus, albumin, creatinine, alkaline phosphatase, 25 (OH) vitamin D3, intact parathormone (PTH) levels (both cases and controls) and HbA1c, antimicrosomal and IgA tissue transglutaminase (IgA TTG) antibodies, cortisol, follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG), tetraiodothyronine (T4), thyroid stimulating hormone (TSH), growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP3) (cases only). T1DM cases had a lower BMD as compared to controls at both total body (TB) and lumbar spine (LS) (). Patients with celiac autoimmunity (CA) had significantly, lower BMD as compared to age, sex, and body mass index (BMI) matched T1DM controls. Linear regression analysis showed that low BMD in T1DM patients was associated with poor glycaemic control, lower IGF-1 levels, less physical activity (in total population as well as in male and female subgroups), and lower body fat percentage (in females) and higher alkaline phosphatase level (in males) ().http://dx.doi.org/10.1155/2013/397814 |
| spellingShingle | Ameya Joshi Premlata Varthakavi Manoj Chadha Nikhil Bhagwat A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus Journal of Osteoporosis |
| title | A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus |
| title_full | A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus |
| title_fullStr | A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus |
| title_full_unstemmed | A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus |
| title_short | A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus |
| title_sort | study of bone mineral density and its determinants in type 1 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2013/397814 |
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