Selected Biomarkers Correlate with the Origin and Severity of Sepsis
The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7028267 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550065943609344 |
|---|---|
| author | Michal Holub Olga Džupová Michaela Růžková Alžběta Stráníková Eva Bartáková Jan Máca Jiří Beneš Heiko Herwald Ondřej Beran |
| author_facet | Michal Holub Olga Džupová Michaela Růžková Alžběta Stráníková Eva Bartáková Jan Máca Jiří Beneš Heiko Herwald Ondřej Beran |
| author_sort | Michal Holub |
| collection | DOAJ |
| description | The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n=10) and infective endocarditis (IE; n=11) compared to those with bacterial meningitis (BM; n=18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction. |
| format | Article |
| id | doaj-art-5cbabfe07da148179304928405b10f24 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5cbabfe07da148179304928405b10f242025-02-03T06:07:47ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/70282677028267Selected Biomarkers Correlate with the Origin and Severity of SepsisMichal Holub0Olga Džupová1Michaela Růžková2Alžběta Stráníková3Eva Bartáková4Jan Máca5Jiří Beneš6Heiko Herwald7Ondřej Beran8Department of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, U Vojenské nemocnice 1200, 169 02 Praha 6, Czech RepublicDepartment of Infectious Diseases, Third Faculty of Medicine, Charles University and Na Bulovce Hospital, Budínova 2, 180 81 Praha 8, Czech RepublicDepartment of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, U Vojenské nemocnice 1200, 169 02 Praha 6, Czech RepublicDepartment of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, U Vojenské nemocnice 1200, 169 02 Praha 6, Czech RepublicDepartment of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, U Vojenské nemocnice 1200, 169 02 Praha 6, Czech RepublicDepartment of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, U Vojenské nemocnice 1200, 169 02 Praha 6, Czech RepublicDepartment of Infectious Diseases, Third Faculty of Medicine, Charles University and Na Bulovce Hospital, Budínova 2, 180 81 Praha 8, Czech RepublicDepartment of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, U Vojenské nemocnice 1200, 169 02 Praha 6, Czech RepublicDepartment of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, U Vojenské nemocnice 1200, 169 02 Praha 6, Czech RepublicThe microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n=10) and infective endocarditis (IE; n=11) compared to those with bacterial meningitis (BM; n=18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.http://dx.doi.org/10.1155/2018/7028267 |
| spellingShingle | Michal Holub Olga Džupová Michaela Růžková Alžběta Stráníková Eva Bartáková Jan Máca Jiří Beneš Heiko Herwald Ondřej Beran Selected Biomarkers Correlate with the Origin and Severity of Sepsis Mediators of Inflammation |
| title | Selected Biomarkers Correlate with the Origin and Severity of Sepsis |
| title_full | Selected Biomarkers Correlate with the Origin and Severity of Sepsis |
| title_fullStr | Selected Biomarkers Correlate with the Origin and Severity of Sepsis |
| title_full_unstemmed | Selected Biomarkers Correlate with the Origin and Severity of Sepsis |
| title_short | Selected Biomarkers Correlate with the Origin and Severity of Sepsis |
| title_sort | selected biomarkers correlate with the origin and severity of sepsis |
| url | http://dx.doi.org/10.1155/2018/7028267 |
| work_keys_str_mv | AT michalholub selectedbiomarkerscorrelatewiththeoriginandseverityofsepsis AT olgadzupova selectedbiomarkerscorrelatewiththeoriginandseverityofsepsis AT michaelaruzkova selectedbiomarkerscorrelatewiththeoriginandseverityofsepsis AT alzbetastranikova selectedbiomarkerscorrelatewiththeoriginandseverityofsepsis AT evabartakova selectedbiomarkerscorrelatewiththeoriginandseverityofsepsis AT janmaca selectedbiomarkerscorrelatewiththeoriginandseverityofsepsis AT jiribenes selectedbiomarkerscorrelatewiththeoriginandseverityofsepsis AT heikoherwald selectedbiomarkerscorrelatewiththeoriginandseverityofsepsis AT ondrejberan selectedbiomarkerscorrelatewiththeoriginandseverityofsepsis |