Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women

ABSTRACT Objective: To assess the genotypic and allelic distribution of the rs10046 polymorphism in the CYP19A1 gene and evaluate whether this aromatase gene variant is associated with cardiovascular risk in postmenopausal women. Materials and methods: This cross-sectional study analyzed repositor...

Full description

Saved in:
Bibliographic Details
Main Authors: Betânia Rodrigues dos Santos, Gislaine Casanova, Thais Rasia da Silva, Karen Oppermann, Poli Mara Spritzer
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism 2025-01-01
Series:Archives of Endocrinology and Metabolism
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000304&lng=en&tlng=en
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832592454215270400
author Betânia Rodrigues dos Santos
Gislaine Casanova
Thais Rasia da Silva
Karen Oppermann
Poli Mara Spritzer
author_facet Betânia Rodrigues dos Santos
Gislaine Casanova
Thais Rasia da Silva
Karen Oppermann
Poli Mara Spritzer
author_sort Betânia Rodrigues dos Santos
collection DOAJ
description ABSTRACT Objective: To assess the genotypic and allelic distribution of the rs10046 polymorphism in the CYP19A1 gene and evaluate whether this aromatase gene variant is associated with cardiovascular risk in postmenopausal women. Materials and methods: This cross-sectional study analyzed repository-stored samples from 370 postmenopausal women aged 44-72 years. Clinical, metabolic, and hormonal data were collected. The patients’ estimated 10-year atherosclerotic cardiovascular disease (ASCVD) risk was calculated using the ASCVD Risk Estimator Plus, as recommended by the American College of Cardiology/American Heart Association. Genotyping of the rs10046 polymorphism of the CYP19A1 gene was carried out using real-time polymerase chain reaction with allelic discrimination assays. Results: The participants had a mean age of 56.07 ± 5.58 years and a mean body mass index (BMI) of 27.73 ± 5.41 kg/m². The 10-year ASCVD risk was estimated to be low, borderline, intermediate, and high in 64.7%, 12.8%, 19.8%, and 2.7% of the participants, respectively. The CC genotype of the rs10046 polymorphism was associated with low estradiol levels (p = 0.003) and high ASCVD scores (p = 0.014). In a multivariate model, age (p < 0.001) and CC genotype (p = 0.021) were independently associated with higher ASCVD risk. Conclusion: The present study found that the CC genotype of the rs10046 polymorphism in the CYP19A1 gene is associated with low estradiol levels and an increased ASCVD risk. Additionally, the results indicated that, among postmenopausal women, age and the CC genotype of rs10046 were associated with a high prevalence of ASCVD risk, independent of BMI.
format Article
id doaj-art-5cb66be5173d4182affb0c706db45242
institution Kabale University
issn 2359-4292
language English
publishDate 2025-01-01
publisher Brazilian Society of Endocrinology and Metabolism
record_format Article
series Archives of Endocrinology and Metabolism
spelling doaj-art-5cb66be5173d4182affb0c706db452422025-01-21T07:45:33ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-01-0168spe110.20945/2359-4292-2024-0087Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal womenBetânia Rodrigues dos Santoshttps://orcid.org/0000-0003-3748-0856Gislaine Casanovahttps://orcid.org/0000-0003-0642-6857Thais Rasia da Silvahttps://orcid.org/0000-0003-4098-1600Karen Oppermannhttps://orcid.org/0000-0002-5711-4653Poli Mara Spritzerhttps://orcid.org/0000-0002-6734-7688ABSTRACT Objective: To assess the genotypic and allelic distribution of the rs10046 polymorphism in the CYP19A1 gene and evaluate whether this aromatase gene variant is associated with cardiovascular risk in postmenopausal women. Materials and methods: This cross-sectional study analyzed repository-stored samples from 370 postmenopausal women aged 44-72 years. Clinical, metabolic, and hormonal data were collected. The patients’ estimated 10-year atherosclerotic cardiovascular disease (ASCVD) risk was calculated using the ASCVD Risk Estimator Plus, as recommended by the American College of Cardiology/American Heart Association. Genotyping of the rs10046 polymorphism of the CYP19A1 gene was carried out using real-time polymerase chain reaction with allelic discrimination assays. Results: The participants had a mean age of 56.07 ± 5.58 years and a mean body mass index (BMI) of 27.73 ± 5.41 kg/m². The 10-year ASCVD risk was estimated to be low, borderline, intermediate, and high in 64.7%, 12.8%, 19.8%, and 2.7% of the participants, respectively. The CC genotype of the rs10046 polymorphism was associated with low estradiol levels (p = 0.003) and high ASCVD scores (p = 0.014). In a multivariate model, age (p < 0.001) and CC genotype (p = 0.021) were independently associated with higher ASCVD risk. Conclusion: The present study found that the CC genotype of the rs10046 polymorphism in the CYP19A1 gene is associated with low estradiol levels and an increased ASCVD risk. Additionally, the results indicated that, among postmenopausal women, age and the CC genotype of rs10046 were associated with a high prevalence of ASCVD risk, independent of BMI.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000304&lng=en&tlng=enAromatase gene variantsestradiolASCVDmenopause
spellingShingle Betânia Rodrigues dos Santos
Gislaine Casanova
Thais Rasia da Silva
Karen Oppermann
Poli Mara Spritzer
Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women
Archives of Endocrinology and Metabolism
Aromatase gene variants
estradiol
ASCVD
menopause
title Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women
title_full Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women
title_fullStr Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women
title_full_unstemmed Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women
title_short Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women
title_sort association between the aromatase cyp19a1 gene variant rs10046 and cardiovascular risk in postmenopausal women
topic Aromatase gene variants
estradiol
ASCVD
menopause
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000304&lng=en&tlng=en
work_keys_str_mv AT betaniarodriguesdossantos associationbetweenthearomatasecyp19a1genevariantrs10046andcardiovascularriskinpostmenopausalwomen
AT gislainecasanova associationbetweenthearomatasecyp19a1genevariantrs10046andcardiovascularriskinpostmenopausalwomen
AT thaisrasiadasilva associationbetweenthearomatasecyp19a1genevariantrs10046andcardiovascularriskinpostmenopausalwomen
AT karenoppermann associationbetweenthearomatasecyp19a1genevariantrs10046andcardiovascularriskinpostmenopausalwomen
AT polimaraspritzer associationbetweenthearomatasecyp19a1genevariantrs10046andcardiovascularriskinpostmenopausalwomen