Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis
Introduction. The correct diagnosis of neonatal sepsis is a relevant problem because sepsis is one of the most important causes of neonatal morbidity, mortality, and prolonged hospital stay. Calprotectin is an antimicrobial, calcium and zinc binding heterocomplex protein that could be used as a nons...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/147973 |
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| author | Lidia Decembrino Mara De Amici Margherita Pozzi Annalisa De Silvestri Mauro Stronati |
| author_facet | Lidia Decembrino Mara De Amici Margherita Pozzi Annalisa De Silvestri Mauro Stronati |
| author_sort | Lidia Decembrino |
| collection | DOAJ |
| description | Introduction. The correct diagnosis of neonatal sepsis is a relevant problem because sepsis is one of the most important causes of neonatal morbidity, mortality, and prolonged hospital stay. Calprotectin is an antimicrobial, calcium and zinc binding heterocomplex protein that could be used as a nonspecific marker for activation of granulocytes and mononuclear phagocytes. Calprotectin has been proposed for the diagnosis of inflammatory conditions. Our aim is to study serum calprotectin as a biomarker for neonatal sepsis diagnosis. Methods. 41 (20 females, 21 males) infants who underwent blood culture due to suspected sepsis were enrolled in the study. Serum calprotectin was measured by a commercial ELISA assay (Calprest, Eurospital, Trieste, Italy). Statistical analysis was performed using the statistical software package Stata 13.1 (Stata Corporation, College Station, Texas, USA). Results. 8 neonates (19.51%) showed sepsis with positive culture and 33 (80.49%) showed suspected sepsis. The optimal cut-off for calprotectin is 2.2 μg/mL with a sensitivity of 62.5% and a specificity of 69.7%. Conclusions. Calprotectin may be considered a promising early, sensitive, specific marker of sepsis thanks to the importance of calprotectin in defense mechanisms and physiological functions of the immune system. |
| format | Article |
| id | doaj-art-5cb5f31de6c84fb08f44993af57bc6c3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5cb5f31de6c84fb08f44993af57bc6c32025-02-03T01:27:37ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/147973147973Serum Calprotectin: A Potential Biomarker for Neonatal SepsisLidia Decembrino0Mara De Amici1Margherita Pozzi2Annalisa De Silvestri3Mauro Stronati4Neonatology and Neonatal Intensive Care Unit, IRCCS San Matteo Foundation, 27100 Pavia, ItalyPediatric Clinic, IRCCS San Matteo Foundation, 27100 Pavia, ItalyNeonatology and Neonatal Intensive Care Unit, IRCCS San Matteo Foundation, 27100 Pavia, ItalyBiometry and Statistics Service, IRCCS San Matteo Foundation, 27100 Pavia, ItalyNeonatology and Neonatal Intensive Care Unit, IRCCS San Matteo Foundation, 27100 Pavia, ItalyIntroduction. The correct diagnosis of neonatal sepsis is a relevant problem because sepsis is one of the most important causes of neonatal morbidity, mortality, and prolonged hospital stay. Calprotectin is an antimicrobial, calcium and zinc binding heterocomplex protein that could be used as a nonspecific marker for activation of granulocytes and mononuclear phagocytes. Calprotectin has been proposed for the diagnosis of inflammatory conditions. Our aim is to study serum calprotectin as a biomarker for neonatal sepsis diagnosis. Methods. 41 (20 females, 21 males) infants who underwent blood culture due to suspected sepsis were enrolled in the study. Serum calprotectin was measured by a commercial ELISA assay (Calprest, Eurospital, Trieste, Italy). Statistical analysis was performed using the statistical software package Stata 13.1 (Stata Corporation, College Station, Texas, USA). Results. 8 neonates (19.51%) showed sepsis with positive culture and 33 (80.49%) showed suspected sepsis. The optimal cut-off for calprotectin is 2.2 μg/mL with a sensitivity of 62.5% and a specificity of 69.7%. Conclusions. Calprotectin may be considered a promising early, sensitive, specific marker of sepsis thanks to the importance of calprotectin in defense mechanisms and physiological functions of the immune system.http://dx.doi.org/10.1155/2015/147973 |
| spellingShingle | Lidia Decembrino Mara De Amici Margherita Pozzi Annalisa De Silvestri Mauro Stronati Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis Journal of Immunology Research |
| title | Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis |
| title_full | Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis |
| title_fullStr | Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis |
| title_full_unstemmed | Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis |
| title_short | Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis |
| title_sort | serum calprotectin a potential biomarker for neonatal sepsis |
| url | http://dx.doi.org/10.1155/2015/147973 |
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