Multifaceted roles of cGAS-STING pathway in the lung cancer: from mechanisms to translation
Lung cancer (LC) remains one of the most prevalent and lethal malignancies globally, with a 5-year survival rate for advanced cases persistently below 10%. Despite the significant advancements in immunotherapy, a substantial proportion of patients with advanced LC fail to respond effectively to thes...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2024-11-01
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| Online Access: | https://peerj.com/articles/18559.pdf |
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| author | Mingming Wei Qingzhou Li Shengrong Li Dong Wang Yumei Wang |
| author_facet | Mingming Wei Qingzhou Li Shengrong Li Dong Wang Yumei Wang |
| author_sort | Mingming Wei |
| collection | DOAJ |
| description | Lung cancer (LC) remains one of the most prevalent and lethal malignancies globally, with a 5-year survival rate for advanced cases persistently below 10%. Despite the significant advancements in immunotherapy, a substantial proportion of patients with advanced LC fail to respond effectively to these treatments, highlighting an urgent need for novel immunotherapeutic targets. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has gained prominence as a potential target for improving LC immunotherapy due to its pivotal role in enhancing anti-tumor immune responses, augmenting tumor antigen presentation, and promoting T cell infiltration. However, emerging evidence also suggests that the cGAS-STING pathway may have pro-tumorigenic effects in the context of LC. This review aims to provide a comprehensive analysis of the cGAS-STING pathway, including its biological composition, activation mechanisms, and physiological functions, as well as its dual roles in LC and the current and emerging LC treatment strategies that target the pathway. By addressing these aspects, we intend to highlight the potential of the cGAS-STING pathway as a novel immunotherapeutic target, while also considering the challenges and future directions for its clinical application. |
| format | Article |
| id | doaj-art-5cb447fa030740b682cc62792e8600e6 |
| institution | OA Journals |
| issn | 2167-8359 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj-art-5cb447fa030740b682cc62792e8600e62025-08-20T02:22:34ZengPeerJ Inc.PeerJ2167-83592024-11-0112e1855910.7717/peerj.18559Multifaceted roles of cGAS-STING pathway in the lung cancer: from mechanisms to translationMingming Wei0Qingzhou Li1Shengrong Li2Dong Wang3Yumei Wang4School of Basic Medical Sciences, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaSchool of Basic Medical Sciences, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaSchool of Basic Medical Sciences, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaLung cancer (LC) remains one of the most prevalent and lethal malignancies globally, with a 5-year survival rate for advanced cases persistently below 10%. Despite the significant advancements in immunotherapy, a substantial proportion of patients with advanced LC fail to respond effectively to these treatments, highlighting an urgent need for novel immunotherapeutic targets. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has gained prominence as a potential target for improving LC immunotherapy due to its pivotal role in enhancing anti-tumor immune responses, augmenting tumor antigen presentation, and promoting T cell infiltration. However, emerging evidence also suggests that the cGAS-STING pathway may have pro-tumorigenic effects in the context of LC. This review aims to provide a comprehensive analysis of the cGAS-STING pathway, including its biological composition, activation mechanisms, and physiological functions, as well as its dual roles in LC and the current and emerging LC treatment strategies that target the pathway. By addressing these aspects, we intend to highlight the potential of the cGAS-STING pathway as a novel immunotherapeutic target, while also considering the challenges and future directions for its clinical application.https://peerj.com/articles/18559.pdfLung cancercGASSTINGImmunotherapyMolecular mechanism |
| spellingShingle | Mingming Wei Qingzhou Li Shengrong Li Dong Wang Yumei Wang Multifaceted roles of cGAS-STING pathway in the lung cancer: from mechanisms to translation PeerJ Lung cancer cGAS STING Immunotherapy Molecular mechanism |
| title | Multifaceted roles of cGAS-STING pathway in the lung cancer: from mechanisms to translation |
| title_full | Multifaceted roles of cGAS-STING pathway in the lung cancer: from mechanisms to translation |
| title_fullStr | Multifaceted roles of cGAS-STING pathway in the lung cancer: from mechanisms to translation |
| title_full_unstemmed | Multifaceted roles of cGAS-STING pathway in the lung cancer: from mechanisms to translation |
| title_short | Multifaceted roles of cGAS-STING pathway in the lung cancer: from mechanisms to translation |
| title_sort | multifaceted roles of cgas sting pathway in the lung cancer from mechanisms to translation |
| topic | Lung cancer cGAS STING Immunotherapy Molecular mechanism |
| url | https://peerj.com/articles/18559.pdf |
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