Comparison of aggregate and individual participant data approaches to meta-analysis of randomised trials: An observational study.

Comparison of aggregate and individual participant data approaches to meta-analysis of randomised trials: An observational study.

<h4>Background</h4>It remains unclear when standard systematic reviews and meta-analyses that rely on published aggregate data (AD) can provide robust clinical conclusions. We aimed to compare the results from a large cohort of systematic reviews and meta-analyses based on individual par...

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Bibliographic Details
Main Authors: Jayne F Tierney, David J Fisher, Sarah Burdett, Lesley A Stewart, Mahesh K B Parmar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Medicine
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pmed.1003019/1/pmed.1003019.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210215%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210215T172614Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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