Increase of augmentation index (AIx@75): a promising tool for screening hypertensive pregnancy disorders
Abstract Background Screening tools in the first trimester of pregnancy for hypertensive pregnancy disorders need to be determined. Objectives To compare cardiovascular parameters between pregnant (PG) and non-pregnant women (NPG) and to evaluate the sensitivity and specificity of arterial stiffness...
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BMC
2025-04-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-025-07493-4 |
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| author | Patrícia Myriam Antunes de Oliveira-Gomide Marta Luisa Palomero Bueno Mariana de Sena Milagres Signorelli Laura Ferreira Moreira Dos Santos João Oscar Falcão Junior Bruno Almeida Rezende Breno Augusto Ferreira-Silva Jose Felippe Pinho da Silva Maria da Glória Rodrigues-Machado |
| author_facet | Patrícia Myriam Antunes de Oliveira-Gomide Marta Luisa Palomero Bueno Mariana de Sena Milagres Signorelli Laura Ferreira Moreira Dos Santos João Oscar Falcão Junior Bruno Almeida Rezende Breno Augusto Ferreira-Silva Jose Felippe Pinho da Silva Maria da Glória Rodrigues-Machado |
| author_sort | Patrícia Myriam Antunes de Oliveira-Gomide |
| collection | DOAJ |
| description | Abstract Background Screening tools in the first trimester of pregnancy for hypertensive pregnancy disorders need to be determined. Objectives To compare cardiovascular parameters between pregnant (PG) and non-pregnant women (NPG) and to evaluate the sensitivity and specificity of arterial stiffness indices in screening for hypertensive pregnancy disorders and their possible association with the mean uterine artery pulsatility index (MUA-PI). Methods This study included 77 pregnant women (11-13.6 gestational weeks) and 77 age-matched non-pregnant women. Cardiovascular parameters were non-invasively measured using Mobil- O-Graph®, a cuff-based oscillometric device. The Doppler Ultrasonographic was used to evaluate the MUA-PI. Results Augmentation index (AIx@75) was significantly higher in PG compared to NPG. ROC curve of AIx@75 showed area under curve (AUC): 0.7303, Sensitivity: 74.03% and Specificity: 64.94% and Cutoff: 22.50%. The systolic volume index was lower and the heart rate was higher in PG compared to NPG. Of the 77 pregnant women, 12 had an unfavorable outcome with hypertensive changes. Central systolic blood pressure (109.1 ± 8.84mmHg) and AIx@75 (31.97 ± 5.47%) were significantly higher in the group of pregnant women with outcome compared to the group without outcome (103.0 ± 8.53mmHg and 26.80 ± 8.71%). ROC curve showed better performance of the AIx@75 [AUC: 0.7179, Sensitivity: 83.33% and Specificity: 60.00%, Cutoff: 27.67%] compared to MUA-PI [AUC: 0.5098, Sensitivity: 8.333% and Specificity 98.44%]. Conclusions AIx@75 was significantly higher in PG compared to NPG. We compared the AIx@75 of PG with and without outcomes. ROC curve analysis showed that this index could discriminate between PG with and without an outcome. Differently, the MUA-PI did not differ between PG with and without outcome, suggesting the superiority of AIx@75 in relation to MUA-PI as a method of screening in the first trimester for hypertensive disease of pregnancy. AIx@75 did not assotiate with MUA-PI. Prospective studies will be needed to confirm these findings. |
| format | Article |
| id | doaj-art-5cb1fa210f4945a5968ca38a29f49bd7 |
| institution | DOAJ |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-5cb1fa210f4945a5968ca38a29f49bd72025-08-20T03:18:34ZengBMCBMC Pregnancy and Childbirth1471-23932025-04-0125111110.1186/s12884-025-07493-4Increase of augmentation index (AIx@75): a promising tool for screening hypertensive pregnancy disordersPatrícia Myriam Antunes de Oliveira-Gomide0Marta Luisa Palomero Bueno1Mariana de Sena Milagres Signorelli2Laura Ferreira Moreira Dos Santos3João Oscar Falcão Junior4Bruno Almeida Rezende5Breno Augusto Ferreira-Silva6Jose Felippe Pinho da Silva7Maria da Glória Rodrigues-Machado8Faculty of Medical Sciences of Minas GeraisFaculty of Medical Sciences of Minas GeraisFaculty of Medical Sciences of Minas GeraisFaculty of Medical Sciences of Minas GeraisFelício Rocho HospitalFaculty of Medical Sciences of Minas GeraisFaculty of Medical Sciences of Minas GeraisFaculty of Medical Sciences of Minas GeraisFaculty of Medical Sciences of Minas GeraisAbstract Background Screening tools in the first trimester of pregnancy for hypertensive pregnancy disorders need to be determined. Objectives To compare cardiovascular parameters between pregnant (PG) and non-pregnant women (NPG) and to evaluate the sensitivity and specificity of arterial stiffness indices in screening for hypertensive pregnancy disorders and their possible association with the mean uterine artery pulsatility index (MUA-PI). Methods This study included 77 pregnant women (11-13.6 gestational weeks) and 77 age-matched non-pregnant women. Cardiovascular parameters were non-invasively measured using Mobil- O-Graph®, a cuff-based oscillometric device. The Doppler Ultrasonographic was used to evaluate the MUA-PI. Results Augmentation index (AIx@75) was significantly higher in PG compared to NPG. ROC curve of AIx@75 showed area under curve (AUC): 0.7303, Sensitivity: 74.03% and Specificity: 64.94% and Cutoff: 22.50%. The systolic volume index was lower and the heart rate was higher in PG compared to NPG. Of the 77 pregnant women, 12 had an unfavorable outcome with hypertensive changes. Central systolic blood pressure (109.1 ± 8.84mmHg) and AIx@75 (31.97 ± 5.47%) were significantly higher in the group of pregnant women with outcome compared to the group without outcome (103.0 ± 8.53mmHg and 26.80 ± 8.71%). ROC curve showed better performance of the AIx@75 [AUC: 0.7179, Sensitivity: 83.33% and Specificity: 60.00%, Cutoff: 27.67%] compared to MUA-PI [AUC: 0.5098, Sensitivity: 8.333% and Specificity 98.44%]. Conclusions AIx@75 was significantly higher in PG compared to NPG. We compared the AIx@75 of PG with and without outcomes. ROC curve analysis showed that this index could discriminate between PG with and without an outcome. Differently, the MUA-PI did not differ between PG with and without outcome, suggesting the superiority of AIx@75 in relation to MUA-PI as a method of screening in the first trimester for hypertensive disease of pregnancy. AIx@75 did not assotiate with MUA-PI. Prospective studies will be needed to confirm these findings.https://doi.org/10.1186/s12884-025-07493-4EclampsiaPreeclampsiaArterial stiffnessHypertensionSystolic blood pressure |
| spellingShingle | Patrícia Myriam Antunes de Oliveira-Gomide Marta Luisa Palomero Bueno Mariana de Sena Milagres Signorelli Laura Ferreira Moreira Dos Santos João Oscar Falcão Junior Bruno Almeida Rezende Breno Augusto Ferreira-Silva Jose Felippe Pinho da Silva Maria da Glória Rodrigues-Machado Increase of augmentation index (AIx@75): a promising tool for screening hypertensive pregnancy disorders BMC Pregnancy and Childbirth Eclampsia Preeclampsia Arterial stiffness Hypertension Systolic blood pressure |
| title | Increase of augmentation index (AIx@75): a promising tool for screening hypertensive pregnancy disorders |
| title_full | Increase of augmentation index (AIx@75): a promising tool for screening hypertensive pregnancy disorders |
| title_fullStr | Increase of augmentation index (AIx@75): a promising tool for screening hypertensive pregnancy disorders |
| title_full_unstemmed | Increase of augmentation index (AIx@75): a promising tool for screening hypertensive pregnancy disorders |
| title_short | Increase of augmentation index (AIx@75): a promising tool for screening hypertensive pregnancy disorders |
| title_sort | increase of augmentation index aix 75 a promising tool for screening hypertensive pregnancy disorders |
| topic | Eclampsia Preeclampsia Arterial stiffness Hypertension Systolic blood pressure |
| url | https://doi.org/10.1186/s12884-025-07493-4 |
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