Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities
Abstract Autophagy is responsible for maintaining cellular balance and ensuring survival. Autophagy plays a crucial role in the development of diseases, particularly human cancers, with actions that can either promote survival or induce cell death. However, brain tumors contribute to high levels of...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-06063-0 |
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| author | Jiarui Zhang Jinan Zhang Chen Yang |
| author_facet | Jiarui Zhang Jinan Zhang Chen Yang |
| author_sort | Jiarui Zhang |
| collection | DOAJ |
| description | Abstract Autophagy is responsible for maintaining cellular balance and ensuring survival. Autophagy plays a crucial role in the development of diseases, particularly human cancers, with actions that can either promote survival or induce cell death. However, brain tumors contribute to high levels of both mortality and morbidity globally, with resistance to treatments being acquired due to genetic mutations and dysregulation of molecular mechanisms, among other factors. Hence, having knowledge of the role of molecular processes in the advancement of brain tumors is enlightening, and the current review specifically examines the role of autophagy. The discussion would focus on the molecular pathways that control autophagy in brain tumors, and its dual role as a tumor suppressor and a supporter of tumor survival. Autophagy can control the advancement of different types of brain tumors like glioblastoma, glioma, and ependymoma, demonstrating its potential for treatment. Autophagy mechanisms can influence metastasis and drug resistance in glioblastoma, and there is a complex interplay between autophagy and cellular responses to stress like hypoxia and starvation. Autophagy can inhibit the growth of brain tumors by promoting apoptosis. Hence, focusing on autophagy could offer fresh perspectives on creating successful treatments. |
| format | Article |
| id | doaj-art-5cb0d40c57764e36899c215fc263c9f3 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-5cb0d40c57764e36899c215fc263c9f32025-01-19T12:37:28ZengBMCJournal of Translational Medicine1479-58762025-01-0123112310.1186/s12967-024-06063-0Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunitiesJiarui Zhang0Jinan Zhang1Chen Yang2Department of Pathology, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical UniversityAbstract Autophagy is responsible for maintaining cellular balance and ensuring survival. Autophagy plays a crucial role in the development of diseases, particularly human cancers, with actions that can either promote survival or induce cell death. However, brain tumors contribute to high levels of both mortality and morbidity globally, with resistance to treatments being acquired due to genetic mutations and dysregulation of molecular mechanisms, among other factors. Hence, having knowledge of the role of molecular processes in the advancement of brain tumors is enlightening, and the current review specifically examines the role of autophagy. The discussion would focus on the molecular pathways that control autophagy in brain tumors, and its dual role as a tumor suppressor and a supporter of tumor survival. Autophagy can control the advancement of different types of brain tumors like glioblastoma, glioma, and ependymoma, demonstrating its potential for treatment. Autophagy mechanisms can influence metastasis and drug resistance in glioblastoma, and there is a complex interplay between autophagy and cellular responses to stress like hypoxia and starvation. Autophagy can inhibit the growth of brain tumors by promoting apoptosis. Hence, focusing on autophagy could offer fresh perspectives on creating successful treatments.https://doi.org/10.1186/s12967-024-06063-0AutophagyGlioblastomaBrain tumorCancer progression |
| spellingShingle | Jiarui Zhang Jinan Zhang Chen Yang Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities Journal of Translational Medicine Autophagy Glioblastoma Brain tumor Cancer progression |
| title | Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities |
| title_full | Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities |
| title_fullStr | Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities |
| title_full_unstemmed | Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities |
| title_short | Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities |
| title_sort | autophagy in brain tumors molecular mechanisms challenges and therapeutic opportunities |
| topic | Autophagy Glioblastoma Brain tumor Cancer progression |
| url | https://doi.org/10.1186/s12967-024-06063-0 |
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