Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

BackgroundThis study investigates whether Hypoxia-Inducible Factor 1 alpha (HIF1α) and Hypoxia-Inducible Factor 2 alpha (HIF2α) coordinately regulate insulin-like growth factor 1 receptor (IGF1R) expression, thereby influencing chemosensitivity in glioblastoma multiforme (GBM).MethodsWe analyzed the...

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Bibliographic Details
Main Authors: Bin Liao, Pan Wang, Sheng Gong, Lu Zhao, Jie Liu, Nan Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
glioblastoma multiforme
HIF1α
HIF2α
IGF1R
hypoxic microenvironment
chemoresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1575332/full
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