Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits
Pyrroloquinoline Quinone (PQQ) is a redox-active quinone molecule with significant implications for human health. Originally identified as a bacterial cofactor, PQQ has since been lauded for its diverse biological and therapeutic activities. It serves as an essential cofactor for oxidative enzymes t...
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Elsevier
2024-01-01
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| Series: | Current Research in Food Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927124002156 |
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| author | Tingdong Yan Muhammad Farrukh Nisar Xiaomeng Hu Jieming Chang Yichen Wang Yan Wu Zhaoguo Liu Yi Cai Jia Jia Yanming Xiao Chunpeng Wan |
| author_facet | Tingdong Yan Muhammad Farrukh Nisar Xiaomeng Hu Jieming Chang Yichen Wang Yan Wu Zhaoguo Liu Yi Cai Jia Jia Yanming Xiao Chunpeng Wan |
| author_sort | Tingdong Yan |
| collection | DOAJ |
| description | Pyrroloquinoline Quinone (PQQ) is a redox-active quinone molecule with significant implications for human health. Originally identified as a bacterial cofactor, PQQ has since been lauded for its diverse biological and therapeutic activities. It serves as an essential cofactor for oxidative enzymes that are vital for mitochondrial function and ATP synthesis. PQQ exhibits superior antioxidant properties that protect against ROS-mediated oxidative stress, aging, neurodegenerative diseases, certain cancers, diabetes, and metabolic disorders. It also enhances cognitive abilities and reduces insulin sensitivity. PQQ's antioxidant nature helps mitigate oxidative stress, which is implicated in many diseases. It has been shown to target cancer cells selectively, suggesting its potential as a therapeutic agent. Clinical studies have indicated the potential benefits of PQQ supplementation, including improvements in cardiovascular health, cognitive function, weight management, insulin sensitivity, and the prevention of metabolic syndromes. The safety of PQQ has been established, with no reported toxicity or genotoxicity in various studies, and it is considered a safe nutritional supplement. Future research directions should focus on determining the optimal dosages of PQQ for specific health outcomes and assessing its long-term effectiveness and safety. The translation of PQQ research into clinical practice could offer new strategies for managing metabolic disorders, enhancing cognitive health, and potentially extending lifespan. In summary, PQQ is a promising molecule with broad potential health benefits, impacting human health from cellular metabolism to disease prevention and treatment, positioning it as a key player in nutritional science and public health. |
| format | Article |
| id | doaj-art-5caa3fed399f4dbf9c3ab4bf4bea8b8e |
| institution | OA Journals |
| issn | 2665-9271 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj-art-5caa3fed399f4dbf9c3ab4bf4bea8b8e2025-08-20T02:38:06ZengElsevierCurrent Research in Food Science2665-92712024-01-01910088910.1016/j.crfs.2024.100889Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefitsTingdong Yan0Muhammad Farrukh Nisar1Xiaomeng Hu2Jieming Chang3Yichen Wang4Yan Wu5Zhaoguo Liu6Yi Cai7Jia Jia8Yanming Xiao9Chunpeng Wan10Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China; Corresponding author.Ministry of Education and Jiangxi Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Jiangxi Agricultural University, Nanchang 330045, China; Jiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, Jiangxi Agricultural University, Nanchang 330045, China; Department of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur, 63100, PakistanTranslational Medicine Center, Zhejiang Xinda Hospital, School of Medicine & Nursing, Huzhou University, Huzhou 313099, ChinaDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, ChinaDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, ChinaTranslational Medicine Center, Zhejiang Xinda Hospital, School of Medicine & Nursing, Huzhou University, Huzhou 313099, ChinaDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, ChinaKey Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, ChinaTranslational Medicine Center, Zhejiang Xinda Hospital, School of Medicine & Nursing, Huzhou University, Huzhou 313099, ChinaHangzhou Hyproven Biopharm Co., Ltd., Hangzhou 311107, ChinaJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, Jiangxi Agricultural University, Nanchang 330045, China; Corresponding author.Pyrroloquinoline Quinone (PQQ) is a redox-active quinone molecule with significant implications for human health. Originally identified as a bacterial cofactor, PQQ has since been lauded for its diverse biological and therapeutic activities. It serves as an essential cofactor for oxidative enzymes that are vital for mitochondrial function and ATP synthesis. PQQ exhibits superior antioxidant properties that protect against ROS-mediated oxidative stress, aging, neurodegenerative diseases, certain cancers, diabetes, and metabolic disorders. It also enhances cognitive abilities and reduces insulin sensitivity. PQQ's antioxidant nature helps mitigate oxidative stress, which is implicated in many diseases. It has been shown to target cancer cells selectively, suggesting its potential as a therapeutic agent. Clinical studies have indicated the potential benefits of PQQ supplementation, including improvements in cardiovascular health, cognitive function, weight management, insulin sensitivity, and the prevention of metabolic syndromes. The safety of PQQ has been established, with no reported toxicity or genotoxicity in various studies, and it is considered a safe nutritional supplement. Future research directions should focus on determining the optimal dosages of PQQ for specific health outcomes and assessing its long-term effectiveness and safety. The translation of PQQ research into clinical practice could offer new strategies for managing metabolic disorders, enhancing cognitive health, and potentially extending lifespan. In summary, PQQ is a promising molecule with broad potential health benefits, impacting human health from cellular metabolism to disease prevention and treatment, positioning it as a key player in nutritional science and public health.http://www.sciencedirect.com/science/article/pii/S2665927124002156Pyrroloquinoline quinoneCellular metabolismAntioxidantNeuroprotectionMetabolic disordersCardiovascular health |
| spellingShingle | Tingdong Yan Muhammad Farrukh Nisar Xiaomeng Hu Jieming Chang Yichen Wang Yan Wu Zhaoguo Liu Yi Cai Jia Jia Yanming Xiao Chunpeng Wan Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits Current Research in Food Science Pyrroloquinoline quinone Cellular metabolism Antioxidant Neuroprotection Metabolic disorders Cardiovascular health |
| title | Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits |
| title_full | Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits |
| title_fullStr | Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits |
| title_full_unstemmed | Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits |
| title_short | Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits |
| title_sort | pyrroloquinoline quinone pqq its impact on human health and potential benefits |
| topic | Pyrroloquinoline quinone Cellular metabolism Antioxidant Neuroprotection Metabolic disorders Cardiovascular health |
| url | http://www.sciencedirect.com/science/article/pii/S2665927124002156 |
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