Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study
Introduction This study aimed to investigate the association between maternal smoking around birth and the incidence of offspring constipation. Methods Genome-wide association study (GWAS) data for maternal smoking around birth and offspring constipation were obtained from the Mendelian randomizati...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2025-05-01
|
| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | https://www.tobaccoinduceddiseases.org/Maternal-smoking-around-birth-is-associated-with-an-increased-risk-of-offspring-constipation,203866,0,2.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849423168701202432 |
|---|---|
| author | Yong Shen<sup>+</sup> Siqi Xie<sup>+</sup> Yu Lin<sup>+</sup> Yifan Fang Bing Zhang Jinna Zhang |
| author_facet | Yong Shen<sup>+</sup> Siqi Xie<sup>+</sup> Yu Lin<sup>+</sup> Yifan Fang Bing Zhang Jinna Zhang |
| author_sort | Yong Shen<sup>+</sup> |
| collection | DOAJ |
| description | Introduction
This study aimed to investigate the association between maternal
smoking around birth and the incidence of offspring constipation.
Methods
Genome-wide association study (GWAS) data for maternal smoking
around birth and offspring constipation were obtained from the Mendelian
randomization (MR) Base platform. Single nucleotide polymorphisms (SNPs)
significantly associated with maternal smoking around birth were utilized as
instrumental variables in two-sample MR analyses to explore the relationship
between maternal smoking and offspring constipation. The analytical methods
employed included the inverse-variance weighted (IVW) method, weighted
median estimator, and MR-Egger regression.
Results
Twenty SNPs significantly associated with maternal smoking around birth
(p<5×10 -8 ; linkage disequilibrium r 2 <0.001) were identified. Across the different
methods, a consistent positive association was observed between maternal smoking
around birth and an increased risk of constipation in offspring (IVW: OR=4.35;
95% CI: 1.81–10.45; weighted median estimator: OR=4.23; 95% CI: 1.22–14.75;
MR-Egger: OR=0.92; 95% CI: 0.01–122.07), suggesting that higher frequency of
maternal smoking is associated with an elevated risk of constipation in offspring.
However, we did not detect any potential effect of genetic liability to constipation
risk on maternal smoking.
Conclusions
This study provides evidence suggesting that increased maternal
smoking around the time of birth may be linked to a higher risk of constipation
in offspring. |
| format | Article |
| id | doaj-art-5ca92afc42a2428d88db42ef3aaf2e74 |
| institution | Kabale University |
| issn | 1617-9625 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj-art-5ca92afc42a2428d88db42ef3aaf2e742025-08-20T03:30:44ZengEuropean PublishingTobacco Induced Diseases1617-96252025-05-0123May11010.18332/tid/203866203866Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization studyYong Shen<sup>+</sup>0https://orcid.org/0000-0003-1809-1791Siqi Xie<sup>+</sup>1https://orcid.org/0000-0002-3831-1678Yu Lin<sup>+</sup>2Yifan Fang3Bing Zhang4Jinna Zhang5https://orcid.org/0000-0002-5001-4756Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaFujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaFujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaFujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaFujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaFujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaIntroduction This study aimed to investigate the association between maternal smoking around birth and the incidence of offspring constipation. Methods Genome-wide association study (GWAS) data for maternal smoking around birth and offspring constipation were obtained from the Mendelian randomization (MR) Base platform. Single nucleotide polymorphisms (SNPs) significantly associated with maternal smoking around birth were utilized as instrumental variables in two-sample MR analyses to explore the relationship between maternal smoking and offspring constipation. The analytical methods employed included the inverse-variance weighted (IVW) method, weighted median estimator, and MR-Egger regression. Results Twenty SNPs significantly associated with maternal smoking around birth (p<5×10 -8 ; linkage disequilibrium r 2 <0.001) were identified. Across the different methods, a consistent positive association was observed between maternal smoking around birth and an increased risk of constipation in offspring (IVW: OR=4.35; 95% CI: 1.81–10.45; weighted median estimator: OR=4.23; 95% CI: 1.22–14.75; MR-Egger: OR=0.92; 95% CI: 0.01–122.07), suggesting that higher frequency of maternal smoking is associated with an elevated risk of constipation in offspring. However, we did not detect any potential effect of genetic liability to constipation risk on maternal smoking. Conclusions This study provides evidence suggesting that increased maternal smoking around the time of birth may be linked to a higher risk of constipation in offspring.https://www.tobaccoinduceddiseases.org/Maternal-smoking-around-birth-is-associated-with-an-increased-risk-of-offspring-constipation,203866,0,2.htmlmaternal smoking around birthconstipationchildhood constipationtobacco smoke exposemendelian randomization |
| spellingShingle | Yong Shen<sup>+</sup> Siqi Xie<sup>+</sup> Yu Lin<sup>+</sup> Yifan Fang Bing Zhang Jinna Zhang Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study Tobacco Induced Diseases maternal smoking around birth constipation childhood constipation tobacco smoke expose mendelian randomization |
| title | Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study |
| title_full | Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study |
| title_fullStr | Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study |
| title_full_unstemmed | Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study |
| title_short | Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study |
| title_sort | maternal smoking around birth is associated with an increased risk of offspring constipation evidence from a mendelian randomization study |
| topic | maternal smoking around birth constipation childhood constipation tobacco smoke expose mendelian randomization |
| url | https://www.tobaccoinduceddiseases.org/Maternal-smoking-around-birth-is-associated-with-an-increased-risk-of-offspring-constipation,203866,0,2.html |
| work_keys_str_mv | AT yongshensupsup maternalsmokingaroundbirthisassociatedwithanincreasedriskofoffspringconstipationevidencefromamendelianrandomizationstudy AT siqixiesupsup maternalsmokingaroundbirthisassociatedwithanincreasedriskofoffspringconstipationevidencefromamendelianrandomizationstudy AT yulinsupsup maternalsmokingaroundbirthisassociatedwithanincreasedriskofoffspringconstipationevidencefromamendelianrandomizationstudy AT yifanfang maternalsmokingaroundbirthisassociatedwithanincreasedriskofoffspringconstipationevidencefromamendelianrandomizationstudy AT bingzhang maternalsmokingaroundbirthisassociatedwithanincreasedriskofoffspringconstipationevidencefromamendelianrandomizationstudy AT jinnazhang maternalsmokingaroundbirthisassociatedwithanincreasedriskofoffspringconstipationevidencefromamendelianrandomizationstudy |