Sociodemographic and clinical features related to hepatitis B virus infection among rejected blood donors in Luanda, Angola
Abstract Background Hepatitis B virus (HBV) remains a public health concern. Blood donors screened for HBV surface antigen (HBsAg) along with aspartate transaminase (AST)/alanine aminotransferase (ALT) could play a key in providing safe blood products. We investigated the features related to HBV inf...
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Wiley
2024-08-01
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| Online Access: | https://doi.org/10.1002/hsr2.2287 |
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| author | Domingos Jandondo Victor Pimentel João Vigário Pedro Vienga Joana M. K. Sebastião Anabela Mateus Felícia Comandante Euclides Sacomboio Ana Abecasis Eunice Manico Deodete Machado Zinga David Jocelyne Neto deVasconcelos Joana Morais Cruz S. Sebastião |
| author_facet | Domingos Jandondo Victor Pimentel João Vigário Pedro Vienga Joana M. K. Sebastião Anabela Mateus Felícia Comandante Euclides Sacomboio Ana Abecasis Eunice Manico Deodete Machado Zinga David Jocelyne Neto deVasconcelos Joana Morais Cruz S. Sebastião |
| author_sort | Domingos Jandondo |
| collection | DOAJ |
| description | Abstract Background Hepatitis B virus (HBV) remains a public health concern. Blood donors screened for HBV surface antigen (HBsAg) along with aspartate transaminase (AST)/alanine aminotransferase (ALT) could play a key in providing safe blood products. We investigated the features related to HBV infection among rejected blood donors in Luanda, Angola. Methods This was a cross‐sectional study conducted with 164 rejected donors. Donors were screened for HBsAg from March to May 2022. Overall, 63.4% tested positive for HBV. Results The mean age of the HBV‐positive (29.2 ± 8.02) was lower than the HBV‐negative (33.9 ± 10.0) (p < 0.001). Donors between 20 and 40 years (odds ratio [OR]: 2.34, p = 0.045), females (OR: 1.40, p = 0.516), residents in urbanized areas (OR: 1.23, p = 0.530), low educational (OR: 1.54, p = 0.458), unemployed (OR: 1.65, p = 0.271), and unmarried (OR:1.41, p = 0.616) might be likely to contract HBV. AST/ALT ratio was higher in HBV‐infected (2.07 ± 1.42) than in HBV‐uninfected (1.90 ± 1.14). About 20% of HBV‐positive were classified as having acute liver disease, while 80% with chronic liver disease, based on AST/ALT ratio. Age ranged from 20 to 40 years (OR: 1.97, p = 0.305), females (OR: 1.61, p = 0.557), donors from non‐urbanized (OR: 1.69, p = 0.557), a low educational (OR: 1.64, p = 0.571), and unemployed donors (OR: 1.81, p = 0.289) were likely to develop chronic liver disease. Conclusions Our findings indicated the failure of viral hepatitis control measures. Authorities should consider including HBV nucleic acid testing to ensure early identification of HBV in Angola. |
| format | Article |
| id | doaj-art-5ca59b563e3a46898fa64b79d4bc4d90 |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wiley |
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| spelling | doaj-art-5ca59b563e3a46898fa64b79d4bc4d902025-08-20T03:44:03ZengWileyHealth Science Reports2398-88352024-08-0178n/an/a10.1002/hsr2.2287Sociodemographic and clinical features related to hepatitis B virus infection among rejected blood donors in Luanda, AngolaDomingos Jandondo0Victor Pimentel1João Vigário2Pedro Vienga3Joana M. K. Sebastião4Anabela Mateus5Felícia Comandante6Euclides Sacomboio7Ana Abecasis8Eunice Manico9Deodete Machado10Zinga David11Jocelyne Neto deVasconcelos12Joana Morais13Cruz S. Sebastião14Centro de Investigação em Saúde de Angola (CISA) Caxito AngolaGlobal Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA‐REAL, Instituto de Higiene e Medicina Tropical, IHMT Universidade NOVA de Lisboa, UNL Lisboa PortugalInstituto Nacional de Sangue (INS) Ministério da Saúde Luanda AngolaInstituto Nacional de Investigação em Saúde (INIS) Luanda AngolaInstituto Nacional de Investigação em Saúde (INIS) Luanda AngolaInstituto Nacional de Investigação em Saúde (INIS) Luanda AngolaInstituto Nacional de Sangue (INS) Ministério da Saúde Luanda AngolaInstituto Nacional de Investigação em Saúde (INIS) Luanda AngolaGlobal Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA‐REAL, Instituto de Higiene e Medicina Tropical, IHMT Universidade NOVA de Lisboa, UNL Lisboa PortugalInstituto Nacional de Sangue (INS) Ministério da Saúde Luanda AngolaInstituto Nacional de Sangue (INS) Ministério da Saúde Luanda AngolaInstituto Nacional de Investigação em Saúde (INIS) Luanda AngolaCentro de Investigação em Saúde de Angola (CISA) Caxito AngolaInstituto Nacional de Investigação em Saúde (INIS) Luanda AngolaCentro de Investigação em Saúde de Angola (CISA) Caxito AngolaAbstract Background Hepatitis B virus (HBV) remains a public health concern. Blood donors screened for HBV surface antigen (HBsAg) along with aspartate transaminase (AST)/alanine aminotransferase (ALT) could play a key in providing safe blood products. We investigated the features related to HBV infection among rejected blood donors in Luanda, Angola. Methods This was a cross‐sectional study conducted with 164 rejected donors. Donors were screened for HBsAg from March to May 2022. Overall, 63.4% tested positive for HBV. Results The mean age of the HBV‐positive (29.2 ± 8.02) was lower than the HBV‐negative (33.9 ± 10.0) (p < 0.001). Donors between 20 and 40 years (odds ratio [OR]: 2.34, p = 0.045), females (OR: 1.40, p = 0.516), residents in urbanized areas (OR: 1.23, p = 0.530), low educational (OR: 1.54, p = 0.458), unemployed (OR: 1.65, p = 0.271), and unmarried (OR:1.41, p = 0.616) might be likely to contract HBV. AST/ALT ratio was higher in HBV‐infected (2.07 ± 1.42) than in HBV‐uninfected (1.90 ± 1.14). About 20% of HBV‐positive were classified as having acute liver disease, while 80% with chronic liver disease, based on AST/ALT ratio. Age ranged from 20 to 40 years (OR: 1.97, p = 0.305), females (OR: 1.61, p = 0.557), donors from non‐urbanized (OR: 1.69, p = 0.557), a low educational (OR: 1.64, p = 0.571), and unemployed donors (OR: 1.81, p = 0.289) were likely to develop chronic liver disease. Conclusions Our findings indicated the failure of viral hepatitis control measures. Authorities should consider including HBV nucleic acid testing to ensure early identification of HBV in Angola.https://doi.org/10.1002/hsr2.2287Angolablood donorsHBsAgHBV infectionliver damage |
| spellingShingle | Domingos Jandondo Victor Pimentel João Vigário Pedro Vienga Joana M. K. Sebastião Anabela Mateus Felícia Comandante Euclides Sacomboio Ana Abecasis Eunice Manico Deodete Machado Zinga David Jocelyne Neto deVasconcelos Joana Morais Cruz S. Sebastião Sociodemographic and clinical features related to hepatitis B virus infection among rejected blood donors in Luanda, Angola Health Science Reports Angola blood donors HBsAg HBV infection liver damage |
| title | Sociodemographic and clinical features related to hepatitis B virus infection among rejected blood donors in Luanda, Angola |
| title_full | Sociodemographic and clinical features related to hepatitis B virus infection among rejected blood donors in Luanda, Angola |
| title_fullStr | Sociodemographic and clinical features related to hepatitis B virus infection among rejected blood donors in Luanda, Angola |
| title_full_unstemmed | Sociodemographic and clinical features related to hepatitis B virus infection among rejected blood donors in Luanda, Angola |
| title_short | Sociodemographic and clinical features related to hepatitis B virus infection among rejected blood donors in Luanda, Angola |
| title_sort | sociodemographic and clinical features related to hepatitis b virus infection among rejected blood donors in luanda angola |
| topic | Angola blood donors HBsAg HBV infection liver damage |
| url | https://doi.org/10.1002/hsr2.2287 |
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