An Investigation on the Aggregation and Rheodynamics of Human Red Blood Cells Using High Performance Computations
Studies on the haemodynamics of human circulation are clinically and scientifically important. In order to investigate the effect of deformation and aggregation of red blood cells (RBCs) in blood flow, a computational technique has been developed by coupling the interaction between the fluid and the...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2017/6524156 |
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| author | Dong Xu Chunning Ji Eldad Avital Efstathios Kaliviotis Ante Munjiza John Williams |
| author_facet | Dong Xu Chunning Ji Eldad Avital Efstathios Kaliviotis Ante Munjiza John Williams |
| author_sort | Dong Xu |
| collection | DOAJ |
| description | Studies on the haemodynamics of human circulation are clinically and scientifically important. In order to investigate the effect of deformation and aggregation of red blood cells (RBCs) in blood flow, a computational technique has been developed by coupling the interaction between the fluid and the deformable RBCs. Parallelization was carried out for the coupled code and a high speedup was achieved based on a spatial decomposition. In order to verify the code’s capability of simulating RBC deformation and transport, simulations were carried out for a spherical capsule in a microchannel and multiple RBC transport in a Poiseuille flow. RBC transport in a confined tube was also carried out to simulate the peristaltic effects of microvessels. Relatively large-scale simulations were carried out of the motion of 49,512 RBCs in shear flows, which yielded a hematocrit of 45%. The large-scale feature of the simulation has enabled a macroscale verification and investigation of the overall characteristics of RBC aggregations to be carried out. The results are in excellent agreement with experimental studies and, more specifically, both the experimental and simulation results show uniform RBC distributions under high shear rates (60–100/s) whereas large aggregations were observed under a lower shear rate of 10/s. |
| format | Article |
| id | doaj-art-5ca068545aa54a04936fdf3e70a95db2 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-5ca068545aa54a04936fdf3e70a95db22025-08-20T03:34:14ZengWileyScientifica2090-908X2017-01-01201710.1155/2017/65241566524156An Investigation on the Aggregation and Rheodynamics of Human Red Blood Cells Using High Performance ComputationsDong Xu0Chunning Ji1Eldad Avital2Efstathios Kaliviotis3Ante Munjiza4John Williams5State Key Laboratory of Hydraulic Engineering Simulation and Safety, Tianjin University, Weijin Road, Tianjin 300072, ChinaState Key Laboratory of Hydraulic Engineering Simulation and Safety, Tianjin University, Weijin Road, Tianjin 300072, ChinaSchool of Engineering & Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UKDepartment of Mechanical Engineering and Materials Science and Engineering, Faculty of Engineering and Technology, Cyprus University of Technology, 45 Kitiou Kyprianou, 3041 Limassol, CyprusFaculty of Civil Engineering, University of Split, Split, CroatiaSchool of Engineering & Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UKStudies on the haemodynamics of human circulation are clinically and scientifically important. In order to investigate the effect of deformation and aggregation of red blood cells (RBCs) in blood flow, a computational technique has been developed by coupling the interaction between the fluid and the deformable RBCs. Parallelization was carried out for the coupled code and a high speedup was achieved based on a spatial decomposition. In order to verify the code’s capability of simulating RBC deformation and transport, simulations were carried out for a spherical capsule in a microchannel and multiple RBC transport in a Poiseuille flow. RBC transport in a confined tube was also carried out to simulate the peristaltic effects of microvessels. Relatively large-scale simulations were carried out of the motion of 49,512 RBCs in shear flows, which yielded a hematocrit of 45%. The large-scale feature of the simulation has enabled a macroscale verification and investigation of the overall characteristics of RBC aggregations to be carried out. The results are in excellent agreement with experimental studies and, more specifically, both the experimental and simulation results show uniform RBC distributions under high shear rates (60–100/s) whereas large aggregations were observed under a lower shear rate of 10/s.http://dx.doi.org/10.1155/2017/6524156 |
| spellingShingle | Dong Xu Chunning Ji Eldad Avital Efstathios Kaliviotis Ante Munjiza John Williams An Investigation on the Aggregation and Rheodynamics of Human Red Blood Cells Using High Performance Computations Scientifica |
| title | An Investigation on the Aggregation and Rheodynamics of Human Red Blood Cells Using High Performance Computations |
| title_full | An Investigation on the Aggregation and Rheodynamics of Human Red Blood Cells Using High Performance Computations |
| title_fullStr | An Investigation on the Aggregation and Rheodynamics of Human Red Blood Cells Using High Performance Computations |
| title_full_unstemmed | An Investigation on the Aggregation and Rheodynamics of Human Red Blood Cells Using High Performance Computations |
| title_short | An Investigation on the Aggregation and Rheodynamics of Human Red Blood Cells Using High Performance Computations |
| title_sort | investigation on the aggregation and rheodynamics of human red blood cells using high performance computations |
| url | http://dx.doi.org/10.1155/2017/6524156 |
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