UV–Vis Detection of Thioacetamide: Balancing the Performances of a Mn(III)-Porphyrin, Gold Colloid, and Their Complex for Selecting the Most Sensitive Material

UV–Vis Detection of Thioacetamide: Balancing the Performances of a Mn(III)-Porphyrin, Gold Colloid, and Their Complex for Selecting the Most Sensitive Material

The optical detection of thioacetamide was investigated using a metalated porphyrin, Mn(III)-5,10,15,20-tetrakis-(3,4-dimethoxyphenyl)-21H,23H-porphyrin chloride (Mn-3,4-diMeOPP), a gold colloid solution (AuNPs), and a complex formed between them (Mn-3,4-diMeOPP–AuNPs) in order to select the most se...

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Bibliographic Details
Main Authors: Camelia Epuran, Ion Fratilescu, Ionela Fringu, Anca Lascu, Liliana Halip, Mihaela Gherban, Eugenia Fagadar-Cosma
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Micromachines
Subjects:
manganese porphyrin
UV–Vis sensors
gold nanoparticles
porphyrin–AuNP complex
thioacetamide detection
Online Access:https://www.mdpi.com/2072-666X/16/5/574
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Summary:The optical detection of thioacetamide was investigated using a metalated porphyrin, Mn(III)-5,10,15,20-tetrakis-(3,4-dimethoxyphenyl)-21H,23H-porphyrin chloride (Mn-3,4-diMeOPP), a gold colloid solution (AuNPs), and a complex formed between them (Mn-3,4-diMeOPP–AuNPs) in order to select the most sensitive material and to achieve complementarity between methods. Mn-3,4-diMeOPP, AuNPs, and their complex were synthesized and characterized by means of UV–Vis, FT-IR spectrometry, and AFM investigations. It could be concluded that Mn-3,4-diMeOPP could detect/quantify thioacetamide (TAA) in the range 3.13 × 10<sup>−8</sup> M–7.67 × 10<sup>−7</sup> M in a linear fashion, with a 99.85% confidence coefficient. The gold colloidal particles alone could detect TAA in an extremely narrow concentration domain of 2–9.8 × 10<sup>−7</sup> M, slightly complementary with that of Mn-3,4-diMeOPP. The complex between Mn-3,4-diMeOPP and gold colloid proved to be able to quantify TAA in the trace domain with concentrations of 1.99 × 10<sup>−8</sup> M–1.76 × 10<sup>−7</sup> M in a polynomial fashion, with the method being more difficult. A potential mechanism for TAA detection based on Mn-3,4-diMeOPP is discussed based on computational modeling. The distorted porphyrin conformation and its electronic configuration favor the generation of a grid of electrostatic interactions between porphyrin and TAA.
ISSN:2072-666X

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