Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease
Abnormal urinary findings, such as sterile pyuria, proteinuria, and microscopic hematuria, are often seen in the acute phase of Kawasaki disease (KD). We investigated the potential significance of urinary lactate dehydrogenase (U-LDH) activity and its isozyme patterns in KD. Total U-LDH activity and...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2017/4162597 |
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| author | Yoichi Kawamura Seiichiro Takeshita Takashi Kanai Mari Takizawa Yusuke Yoshida Yuki Tsujita Shigeaki Nonoyama |
| author_facet | Yoichi Kawamura Seiichiro Takeshita Takashi Kanai Mari Takizawa Yusuke Yoshida Yuki Tsujita Shigeaki Nonoyama |
| author_sort | Yoichi Kawamura |
| collection | DOAJ |
| description | Abnormal urinary findings, such as sterile pyuria, proteinuria, and microscopic hematuria, are often seen in the acute phase of Kawasaki disease (KD). We investigated the potential significance of urinary lactate dehydrogenase (U-LDH) activity and its isozyme patterns in KD. Total U-LDH activity and its isozymes (U-LDH1-5) levels were compared among 120 patients with KD, 18 patients with viral infection (VI), and 43 patients with upper urinary tract infection (UTI) and additionally compared between intravenous immunoglobulin (IVIG) responders (n=89) and nonresponders (n=31) with KD. Total U-LDH activity was higher in KD (35.4±4.8 IU/L, P<0.05) and UTI patients (66.0±8.0 IU/L, P<0.01) than in VI patients (17.0±6.2 IU/L). In the isozyme pattern analysis, KD patients had high levels of U-LDH1 and U-LDH2, while UTI patients had high levels of U-LDH3, U-LDH4, and U-LDH5. Furthermore, IVIG nonresponders of KD had significantly higher levels of total U-LDH activity (45.1±4.7 IU/L, P<0.05), especially U-LDH1 and U-LDH2 (P<0.05), than IVIG responders (32.0±2.8 IU/L). KD patients have increased levels of total U-LDH activity, especially U-LDH-1 and U-LDH2, indicating a unique pattern of U-LDH isozymes different from that in UTI patients. |
| format | Article |
| id | doaj-art-5c9dabf3156f4982a11df9064378b191 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-5c9dabf3156f4982a11df9064378b1912025-02-03T05:47:18ZengWileyInternational Journal of Pediatrics1687-97401687-97592017-01-01201710.1155/2017/41625974162597Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki DiseaseYoichi Kawamura0Seiichiro Takeshita1Takashi Kanai2Mari Takizawa3Yusuke Yoshida4Yuki Tsujita5Shigeaki Nonoyama6Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, JapanDivision of Nursing, National Defense Medical College, Tokorozawa, Saitama, JapanDepartment of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, JapanDepartment of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, JapanDepartment of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, JapanDepartment of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, JapanDepartment of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, JapanAbnormal urinary findings, such as sterile pyuria, proteinuria, and microscopic hematuria, are often seen in the acute phase of Kawasaki disease (KD). We investigated the potential significance of urinary lactate dehydrogenase (U-LDH) activity and its isozyme patterns in KD. Total U-LDH activity and its isozymes (U-LDH1-5) levels were compared among 120 patients with KD, 18 patients with viral infection (VI), and 43 patients with upper urinary tract infection (UTI) and additionally compared between intravenous immunoglobulin (IVIG) responders (n=89) and nonresponders (n=31) with KD. Total U-LDH activity was higher in KD (35.4±4.8 IU/L, P<0.05) and UTI patients (66.0±8.0 IU/L, P<0.01) than in VI patients (17.0±6.2 IU/L). In the isozyme pattern analysis, KD patients had high levels of U-LDH1 and U-LDH2, while UTI patients had high levels of U-LDH3, U-LDH4, and U-LDH5. Furthermore, IVIG nonresponders of KD had significantly higher levels of total U-LDH activity (45.1±4.7 IU/L, P<0.05), especially U-LDH1 and U-LDH2 (P<0.05), than IVIG responders (32.0±2.8 IU/L). KD patients have increased levels of total U-LDH activity, especially U-LDH-1 and U-LDH2, indicating a unique pattern of U-LDH isozymes different from that in UTI patients.http://dx.doi.org/10.1155/2017/4162597 |
| spellingShingle | Yoichi Kawamura Seiichiro Takeshita Takashi Kanai Mari Takizawa Yusuke Yoshida Yuki Tsujita Shigeaki Nonoyama Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease International Journal of Pediatrics |
| title | Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease |
| title_full | Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease |
| title_fullStr | Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease |
| title_full_unstemmed | Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease |
| title_short | Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease |
| title_sort | urinary lactate dehydrogenase activity and its isozyme patterns in kawasaki disease |
| url | http://dx.doi.org/10.1155/2017/4162597 |
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