Sugars on dehydrated phospholipid bilayer: A mini review on its protective mechanisms
Sugars are widely recognized for their ability to stabilize cell membranes during dehydration. However, the precise mechanisms by which sugars interact with lipid bilayers remain unclear. This mini-review synthesizes four key hypotheses explaining sugar-mediated protection of dehydrated bilayers: th...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2025-08-01
|
| Series: | Frigid Zone Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/fzm-2025-0011 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849225099933122560 |
|---|---|
| author | Zuo Qing Gao Cai |
| author_facet | Zuo Qing Gao Cai |
| author_sort | Zuo Qing |
| collection | DOAJ |
| description | Sugars are widely recognized for their ability to stabilize cell membranes during dehydration. However, the precise mechanisms by which sugars interact with lipid bilayers remain unclear. This mini-review synthesizes four key hypotheses explaining sugar-mediated protection of dehydrated bilayers: the Water Replacement Hypothesis (WRH), Hydration Force Hypothesis (HFH), Headgroup Bridging Hypothesis (HBH), and Vitrification Hypothesis (VH). We argue that these mechanisms are not mutually exclusive but instead operate synergistically under different cellular contexts. We propose that these hypotheses are not mutually exclusive but likely operate under different cellular contexts. Future studies should prioritize the development of biologically realistic membrane models—incorporating diverse lipids, proteins, and asymmetric leaflets—to elucidate the exact roles and mechanisms of sugars in membrane stabilization. Such advancements will enhance our understanding of anhydrobiosis and inform cryopreservation strategies for mammalian cells. |
| format | Article |
| id | doaj-art-5c94b73f611b467fa40bfaae9960e978 |
| institution | Kabale University |
| issn | 2719-8073 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Frigid Zone Medicine |
| spelling | doaj-art-5c94b73f611b467fa40bfaae9960e9782025-08-25T06:10:32ZengDe GruyterFrigid Zone Medicine2719-80732025-08-015210811210.1515/fzm-2025-0011Sugars on dehydrated phospholipid bilayer: A mini review on its protective mechanismsZuo Qing0Gao Cai1Department of Refrigeration & Cryogenics Engineering, Hefei University of Technology, Hefei230009, ChinaDepartment of Refrigeration & Cryogenics Engineering, Hefei University of Technology, Hefei230009, ChinaSugars are widely recognized for their ability to stabilize cell membranes during dehydration. However, the precise mechanisms by which sugars interact with lipid bilayers remain unclear. This mini-review synthesizes four key hypotheses explaining sugar-mediated protection of dehydrated bilayers: the Water Replacement Hypothesis (WRH), Hydration Force Hypothesis (HFH), Headgroup Bridging Hypothesis (HBH), and Vitrification Hypothesis (VH). We argue that these mechanisms are not mutually exclusive but instead operate synergistically under different cellular contexts. We propose that these hypotheses are not mutually exclusive but likely operate under different cellular contexts. Future studies should prioritize the development of biologically realistic membrane models—incorporating diverse lipids, proteins, and asymmetric leaflets—to elucidate the exact roles and mechanisms of sugars in membrane stabilization. Such advancements will enhance our understanding of anhydrobiosis and inform cryopreservation strategies for mammalian cells.https://doi.org/10.1515/fzm-2025-0011protection mechanismphospholipid bilayerdehydrationsugars |
| spellingShingle | Zuo Qing Gao Cai Sugars on dehydrated phospholipid bilayer: A mini review on its protective mechanisms Frigid Zone Medicine protection mechanism phospholipid bilayer dehydration sugars |
| title | Sugars on dehydrated phospholipid bilayer: A mini review on its protective mechanisms |
| title_full | Sugars on dehydrated phospholipid bilayer: A mini review on its protective mechanisms |
| title_fullStr | Sugars on dehydrated phospholipid bilayer: A mini review on its protective mechanisms |
| title_full_unstemmed | Sugars on dehydrated phospholipid bilayer: A mini review on its protective mechanisms |
| title_short | Sugars on dehydrated phospholipid bilayer: A mini review on its protective mechanisms |
| title_sort | sugars on dehydrated phospholipid bilayer a mini review on its protective mechanisms |
| topic | protection mechanism phospholipid bilayer dehydration sugars |
| url | https://doi.org/10.1515/fzm-2025-0011 |
| work_keys_str_mv | AT zuoqing sugarsondehydratedphospholipidbilayeraminireviewonitsprotectivemechanisms AT gaocai sugarsondehydratedphospholipidbilayeraminireviewonitsprotectivemechanisms |