Study on the correlation between c-reactive protein, albumin and c-reactive pro-tein/albumin ratio with disease activity of ulcerative colitis
Objective To investigate the correlation of C-reactive protein (CRP), albumin (ALB) and their ratio (CRP/ALB ratio, CAR) with the level of disease activity among patients with ulcerative colitis (UC).Methods 100 patients with UC admitted to Zhongnan Hospital of Wuhan University from March 2017 to Ma...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of New Medicine
2021-10-01
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| Series: | Yixue xinzhi zazhi |
| Subjects: | |
| Online Access: | https://yxxz.whuznhmedj.com/storage/attach/2110/xgCd8pws6nM2IJnHnCyJk8K5yGE5fsU20WnizcKC.pdf |
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| Summary: | Objective To investigate the correlation of C-reactive protein (CRP), albumin (ALB) and their ratio (CRP/ALB ratio, CAR) with the level of disease activity among patients with ulcerative colitis (UC).Methods 100 patients with UC admitted to Zhongnan Hospital of Wuhan University from March 2017 to May 2019 were recruited, along with 100 physically healthy controls matched for age and gen-der. The UC patients were divided into four groups: in remission, mild, moderate and severe active stage. The differences in CRP, ALB and CAR between the control group and the UC group were compared and their correlations analyzed using the modified Mayo score, their effectiveness in diagnosing UC was ana-lyzed using the ROC curve.Results CRP and CAR in the UC group were significantly higher than those in healthy control group, and ALB were significantly lower than those in control group, with statistically significant dif-ferences (P< 0.05). Compared with UC patients in the disease remission stage and those with mild to moderate active stages, CAR in UC patients in the severe active stage were significantly higher, and the differences were statistically significant (P< 0.008).The modified Mayo score of UC patients was positively correlated with CRP and CAR (rCRP=0.546, rCAR=0.559), and negatively correlated with ALB (rALB=-0.448). The ability of the area under curve (AUC) of CRP, ALB, and CAR to distinguish UC disease activity from inactivity is 0.764, 0.726, 0.773, respectively. The sensitivity of CAR in diagnosing UC is 44.3%, and the specificity is 100%. The efficiency is better than CRP and ALB alone.Conclusion CRP, ALB and CAR are significantly correlated with the modified Mayo score, and they can all predict UC disease ac-tivity. Among them, CAR has high predictive specificity and is expected to become a reliable index for assessing UC disease activity. |
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| ISSN: | 1004-5511 |