Epigenetics of obesity
The pathophysiology of obesity is complex and includes changes in eating behavior, genetic, epigenetic, environmental factors, and much more. To date, ~40 genetic polymorphisms are associated with obesity and fat distribution. However, since these options do not fully explain the inheritance of obes...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2020-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2632 |
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| author | O. M. Drapkina O. T. Kim |
| author_facet | O. M. Drapkina O. T. Kim |
| author_sort | O. M. Drapkina |
| collection | DOAJ |
| description | The pathophysiology of obesity is complex and includes changes in eating behavior, genetic, epigenetic, environmental factors, and much more. To date, ~40 genetic polymorphisms are associated with obesity and fat distribution. However, since these options do not fully explain the inheritance of obesity, other options, such as epigenetic changes, need to be considered. Epigenetic modifications affect gene expression without changing the deoxyribonucleic acid sequence. In addition, environmental exposure during critical periods of development can affect the epigenetic tags and lead to obesity. A deeper understanding of the epigenetic mechanisms underlying obesity can aid in prevention based on lifestyle changes. This review focuses on the role of epigenetic modifications in the development of obesity and related conditions. |
| format | Article |
| id | doaj-art-5c8c0b362fdb4f18b2307cf2efdbd870 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-5c8c0b362fdb4f18b2307cf2efdbd8702025-08-20T03:57:13Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252020-12-0119610.15829/1728-8800-2020-26322190Epigenetics of obesityO. M. Drapkina0O. T. Kim1National Research Center for Therapy and Preventive MedicineNational Research Center for Therapy and Preventive MedicineThe pathophysiology of obesity is complex and includes changes in eating behavior, genetic, epigenetic, environmental factors, and much more. To date, ~40 genetic polymorphisms are associated with obesity and fat distribution. However, since these options do not fully explain the inheritance of obesity, other options, such as epigenetic changes, need to be considered. Epigenetic modifications affect gene expression without changing the deoxyribonucleic acid sequence. In addition, environmental exposure during critical periods of development can affect the epigenetic tags and lead to obesity. A deeper understanding of the epigenetic mechanisms underlying obesity can aid in prevention based on lifestyle changes. This review focuses on the role of epigenetic modifications in the development of obesity and related conditions.https://cardiovascular.elpub.ru/jour/article/view/2632obesityepigeneticsgeneticsdeoxyribonucleic acid methylation |
| spellingShingle | O. M. Drapkina O. T. Kim Epigenetics of obesity Кардиоваскулярная терапия и профилактика obesity epigenetics genetics deoxyribonucleic acid methylation |
| title | Epigenetics of obesity |
| title_full | Epigenetics of obesity |
| title_fullStr | Epigenetics of obesity |
| title_full_unstemmed | Epigenetics of obesity |
| title_short | Epigenetics of obesity |
| title_sort | epigenetics of obesity |
| topic | obesity epigenetics genetics deoxyribonucleic acid methylation |
| url | https://cardiovascular.elpub.ru/jour/article/view/2632 |
| work_keys_str_mv | AT omdrapkina epigeneticsofobesity AT otkim epigeneticsofobesity |