Spheroid morphology of lung cancer cell lines correlates with oncological profiles

Spheroid morphology of lung cancer cell lines correlates with oncological profiles

Abstract We assessed the correlation between Multicellular tumor spheroids (MCTS) morphology and the oncological profile of lung cancer cells. MCTS were generated in five lung cancer cell lines and classified into Type–A MCTS, which showed strong aggregation, and Type–B MCTS, which showed weak aggre...

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Main Authors: Kaido Oishi, Keitaro Matsumoto, Shintaro Hashimoto, Fumitake Uchida, Ryosuke Hara, Masato Nishimuta, Takamune Matsumoto, Mayumi Iwatake, Koichi Tomoshige, Ryoichiro Doi, Ryusuke Machino, Tomohiro Obata, Takeshi Nagayasu
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
Cancer spheroid
Epithelial–mesenchymal transition
Invasion ability
Lung cancer
Spheroid morphology
Online Access:https://doi.org/10.1007/s12672-025-02132-y
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Summary:Abstract We assessed the correlation between Multicellular tumor spheroids (MCTS) morphology and the oncological profile of lung cancer cells. MCTS were generated in five lung cancer cell lines and classified into Type–A MCTS, which showed strong aggregation, and Type–B MCTS, which showed weak aggregation. Drug resistance was higher in Type–A MCTS, and invasive ability was higher in Type–B MCTS. The oncologic profile of lung cancer cell lines correlated with MCTS morphology. MCTS morphology could thus be used in basic oncology research and as a clinical prognostic tool. Registry and the Registration No. of the study/trial Not Applicable.
ISSN:2730-6011

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