Varicella Zoster vaccination in hemodialysis patients: The state of the art
Varicella Zoster Virus (VZV) infection is a common childhood exanthematous disease, which in adults and immunocompromised people may result in severe neurologic complications. Up to one-third of infected subjects may have VZV clinical reactivation particularly if immunocompromised. Patients affected...
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| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2023.2286689 |
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| author | Laura Gobbi Francesca Katiana Martino Elena Sgrò Federico Nalesso Lorenzo A. Calo’ |
| author_facet | Laura Gobbi Francesca Katiana Martino Elena Sgrò Federico Nalesso Lorenzo A. Calo’ |
| author_sort | Laura Gobbi |
| collection | DOAJ |
| description | Varicella Zoster Virus (VZV) infection is a common childhood exanthematous disease, which in adults and immunocompromised people may result in severe neurologic complications. Up to one-third of infected subjects may have VZV clinical reactivation particularly if immunocompromised. Patients affected by end-stage renal disease on hemodialysis present immunodepression that contributes to their higher incidence of VZV infections and reactivation. While antiviral treatment in these patients shows low efficacy, the prevention of VZV through vaccination avoids the primary infection and the risk of reactivation. Two VZV vaccines are currently available: the live attenuate Zoster Vaccine (LZV) and a Recombinant Zoster Vaccine (RZV), with the latter appearing to provide greater efficacy. Given the higher incidence of VZV infection and reactivation, the lesser response to antivirals and the lower impact of VZ vaccine in hemodialysis patients in terms of side effects, a higher diffusion of VZV vaccination should be promoted by nephrologists in these patients in particular in those with future transplant opportunities. |
| format | Article |
| id | doaj-art-5c7f64a6d50f4e08a411df8676654e76 |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-5c7f64a6d50f4e08a411df8676654e762025-08-20T02:03:27ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-12-0119310.1080/21645515.2023.2286689Varicella Zoster vaccination in hemodialysis patients: The state of the artLaura Gobbi0Francesca Katiana Martino1Elena Sgrò2Federico Nalesso3Lorenzo A. Calo’4Nephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, Padova, ItalyNephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, Padova, ItalyNephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, Padova, ItalyNephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, Padova, ItalyNephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, Padova, ItalyVaricella Zoster Virus (VZV) infection is a common childhood exanthematous disease, which in adults and immunocompromised people may result in severe neurologic complications. Up to one-third of infected subjects may have VZV clinical reactivation particularly if immunocompromised. Patients affected by end-stage renal disease on hemodialysis present immunodepression that contributes to their higher incidence of VZV infections and reactivation. While antiviral treatment in these patients shows low efficacy, the prevention of VZV through vaccination avoids the primary infection and the risk of reactivation. Two VZV vaccines are currently available: the live attenuate Zoster Vaccine (LZV) and a Recombinant Zoster Vaccine (RZV), with the latter appearing to provide greater efficacy. Given the higher incidence of VZV infection and reactivation, the lesser response to antivirals and the lower impact of VZ vaccine in hemodialysis patients in terms of side effects, a higher diffusion of VZV vaccination should be promoted by nephrologists in these patients in particular in those with future transplant opportunities.https://www.tandfonline.com/doi/10.1080/21645515.2023.2286689Varicella Zoster virus infectionVaricella Zoster virus reactivationZoster vaccineshemodialysisend stage renal disease |
| spellingShingle | Laura Gobbi Francesca Katiana Martino Elena Sgrò Federico Nalesso Lorenzo A. Calo’ Varicella Zoster vaccination in hemodialysis patients: The state of the art Human Vaccines & Immunotherapeutics Varicella Zoster virus infection Varicella Zoster virus reactivation Zoster vaccines hemodialysis end stage renal disease |
| title | Varicella Zoster vaccination in hemodialysis patients: The state of the art |
| title_full | Varicella Zoster vaccination in hemodialysis patients: The state of the art |
| title_fullStr | Varicella Zoster vaccination in hemodialysis patients: The state of the art |
| title_full_unstemmed | Varicella Zoster vaccination in hemodialysis patients: The state of the art |
| title_short | Varicella Zoster vaccination in hemodialysis patients: The state of the art |
| title_sort | varicella zoster vaccination in hemodialysis patients the state of the art |
| topic | Varicella Zoster virus infection Varicella Zoster virus reactivation Zoster vaccines hemodialysis end stage renal disease |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2023.2286689 |
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