Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 Expression
Conclusions: Our study suggests that mandibular defects can induce the activation of PDSCs and inhibit the expression of Dot1l, potentially affecting the Notch signaling pathway. Targeting the Dot1l/Chac1 pathway to regulate the osteogenic differentiation of PDSCs lays a solid foundation for periost...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/sci/1508850 |
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| _version_ | 1850098003421954048 |
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| author | Taoran Jiang Bin Fang Zheyuan Yu Dejun Cao |
| author_facet | Taoran Jiang Bin Fang Zheyuan Yu Dejun Cao |
| author_sort | Taoran Jiang |
| collection | DOAJ |
| description | Conclusions: Our study suggests that mandibular defects can induce the activation of PDSCs and inhibit the expression of Dot1l, potentially affecting the Notch signaling pathway. Targeting the Dot1l/Chac1 pathway to regulate the osteogenic differentiation of PDSCs lays a solid foundation for periosteum-based maxillofacial bone regeneration. |
| format | Article |
| id | doaj-art-5c752246dc904eb2b426236a2ccc68d1 |
| institution | DOAJ |
| issn | 1687-9678 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5c752246dc904eb2b426236a2ccc68d12025-08-20T02:40:48ZengWileyStem Cells International1687-96782025-01-01202510.1155/sci/1508850Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 ExpressionTaoran Jiang0Bin Fang1Zheyuan Yu2Dejun Cao3Department of Plastic and Reconstructive SurgeryDepartment of Plastic and Reconstructive SurgeryDepartment of Plastic and Reconstructive SurgeryDepartment of Plastic and Reconstructive SurgeryConclusions: Our study suggests that mandibular defects can induce the activation of PDSCs and inhibit the expression of Dot1l, potentially affecting the Notch signaling pathway. Targeting the Dot1l/Chac1 pathway to regulate the osteogenic differentiation of PDSCs lays a solid foundation for periosteum-based maxillofacial bone regeneration.http://dx.doi.org/10.1155/sci/1508850 |
| spellingShingle | Taoran Jiang Bin Fang Zheyuan Yu Dejun Cao Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 Expression Stem Cells International |
| title | Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 Expression |
| title_full | Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 Expression |
| title_fullStr | Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 Expression |
| title_full_unstemmed | Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 Expression |
| title_short | Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 Expression |
| title_sort | dot1l regulates the spontaneous bone regeneration of periosteum derived stem cells by regulating chac1 expression |
| url | http://dx.doi.org/10.1155/sci/1508850 |
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