Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010–2022 Cohort
Altered lipid profiles have been observed in acute malaria, though mechanisms remain unclear. The impact of asymptomatic submicroscopic malaria infection (AMI) on lipids is unexploredAn observational, comparative, retrospective study was conducted of 1278 asymptomatic Sub-Saharan African migrants (A...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/10/5/134 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849327082042032128 |
|---|---|
| author | Diego Gayoso-Cantero María Dolores Corbacho-Loarte Clara Crespillo-Andújar Sandra Chamorro-Tojeiro Francesca Norman Jose A. Perez-Molina Marta González-Sanz Oihane Martín José Miguel Rubio Beatriz Gullón-Peña Laura del Campo Albendea Rogelio López-Vélez Begoña Monge-Maillo |
| author_facet | Diego Gayoso-Cantero María Dolores Corbacho-Loarte Clara Crespillo-Andújar Sandra Chamorro-Tojeiro Francesca Norman Jose A. Perez-Molina Marta González-Sanz Oihane Martín José Miguel Rubio Beatriz Gullón-Peña Laura del Campo Albendea Rogelio López-Vélez Begoña Monge-Maillo |
| author_sort | Diego Gayoso-Cantero |
| collection | DOAJ |
| description | Altered lipid profiles have been observed in acute malaria, though mechanisms remain unclear. The impact of asymptomatic submicroscopic malaria infection (AMI) on lipids is unexploredAn observational, comparative, retrospective study was conducted of 1278 asymptomatic Sub-Saharan African migrants (ASSAMs) screened for malaria and lipid profiles during health exams (2010–2022). A systematic screening protocol for infectious disease was performed, including screening for <i>Plasmodium</i> spp. infection by polymerase chain reaction (PCR).Among 800 ASSAMs screened for malaria, 104 (13%) were PCR-positive: <i>P. falciparum</i> (68.72%), <i>P. malariae</i> (18.27%), <i>P. ovale</i> (9.62%), and mixed infections (3.8%). Participants with AMIs exhibited lower baseline lipid levels: total cholesterol (146 vs. 163 mg/dL; <i>p</i> < 0.001), HDL (43 vs. 47 mg/dL; <i>p</i> < 0.001), and LDL (87.5 vs. 98 mg/dL; <i>p</i> < 0.001), with no differences in triglycerides. After treatment, lipid levels partially equalized: total cholesterol (156 vs. 166; <i>p</i> = 0.01), HDL (44 vs. 47.5; <i>p</i> = 0.05), LDL (102 vs. 108.5; <i>p</i> = 0.31), with no changes in triglycerides. Patients with AMI showed higher rates of co-infections (Strongyloides 20.61% vs. 14.35%; <i>p</i> < 0.001; filariae 7.69% vs. 1.91%; <i>p</i> = 0.02) and lower mean corpuscular volume (87.2 vs. 85; <i>p</i> < 0.001). Conclusions: These findings suggest that cholesterol reductions in AMI are not solely due to acute inflammation but may reflect chronic inflammatory processes triggered by asymptomatic malaria. This supports a potential link between AMI and lipid profile changes, underscoring its role in subclinical chronic inflammation. |
| format | Article |
| id | doaj-art-5c6e7151df9341f2b90fcf2f8fb7a8d6 |
| institution | Kabale University |
| issn | 2414-6366 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-5c6e7151df9341f2b90fcf2f8fb7a8d62025-08-20T03:47:58ZengMDPI AGTropical Medicine and Infectious Disease2414-63662025-05-0110513410.3390/tropicalmed10050134Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010–2022 CohortDiego Gayoso-Cantero0María Dolores Corbacho-Loarte1Clara Crespillo-Andújar2Sandra Chamorro-Tojeiro3Francesca Norman4Jose A. Perez-Molina5Marta González-Sanz6Oihane Martín7José Miguel Rubio8Beatriz Gullón-Peña9Laura del Campo Albendea10Rogelio López-Vélez11Begoña Monge-Maillo12National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainCIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, SpainNational Centre for Microbiology, Instituto de Salud Carlos III, 28029 Madrid, SpainNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainClinical Biostatistics Unit, Ramón y Cajal University Hospital, IRYCIS, 28034 Madrid, SpainNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainAltered lipid profiles have been observed in acute malaria, though mechanisms remain unclear. The impact of asymptomatic submicroscopic malaria infection (AMI) on lipids is unexploredAn observational, comparative, retrospective study was conducted of 1278 asymptomatic Sub-Saharan African migrants (ASSAMs) screened for malaria and lipid profiles during health exams (2010–2022). A systematic screening protocol for infectious disease was performed, including screening for <i>Plasmodium</i> spp. infection by polymerase chain reaction (PCR).Among 800 ASSAMs screened for malaria, 104 (13%) were PCR-positive: <i>P. falciparum</i> (68.72%), <i>P. malariae</i> (18.27%), <i>P. ovale</i> (9.62%), and mixed infections (3.8%). Participants with AMIs exhibited lower baseline lipid levels: total cholesterol (146 vs. 163 mg/dL; <i>p</i> < 0.001), HDL (43 vs. 47 mg/dL; <i>p</i> < 0.001), and LDL (87.5 vs. 98 mg/dL; <i>p</i> < 0.001), with no differences in triglycerides. After treatment, lipid levels partially equalized: total cholesterol (156 vs. 166; <i>p</i> = 0.01), HDL (44 vs. 47.5; <i>p</i> = 0.05), LDL (102 vs. 108.5; <i>p</i> = 0.31), with no changes in triglycerides. Patients with AMI showed higher rates of co-infections (Strongyloides 20.61% vs. 14.35%; <i>p</i> < 0.001; filariae 7.69% vs. 1.91%; <i>p</i> = 0.02) and lower mean corpuscular volume (87.2 vs. 85; <i>p</i> < 0.001). Conclusions: These findings suggest that cholesterol reductions in AMI are not solely due to acute inflammation but may reflect chronic inflammatory processes triggered by asymptomatic malaria. This supports a potential link between AMI and lipid profile changes, underscoring its role in subclinical chronic inflammation.https://www.mdpi.com/2414-6366/10/5/134malaria<i>Plasmodium</i>asymptomatic infectionlipid profilecholesterolSub-Saharan Africa |
| spellingShingle | Diego Gayoso-Cantero María Dolores Corbacho-Loarte Clara Crespillo-Andújar Sandra Chamorro-Tojeiro Francesca Norman Jose A. Perez-Molina Marta González-Sanz Oihane Martín José Miguel Rubio Beatriz Gullón-Peña Laura del Campo Albendea Rogelio López-Vélez Begoña Monge-Maillo Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010–2022 Cohort Tropical Medicine and Infectious Disease malaria <i>Plasmodium</i> asymptomatic infection lipid profile cholesterol Sub-Saharan Africa |
| title | Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010–2022 Cohort |
| title_full | Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010–2022 Cohort |
| title_fullStr | Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010–2022 Cohort |
| title_full_unstemmed | Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010–2022 Cohort |
| title_short | Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010–2022 Cohort |
| title_sort | changes in lipid profile secondary to asymptomatic malaria in migrants from sub saharan africa a retrospective analysis of a 2010 2022 cohort |
| topic | malaria <i>Plasmodium</i> asymptomatic infection lipid profile cholesterol Sub-Saharan Africa |
| url | https://www.mdpi.com/2414-6366/10/5/134 |
| work_keys_str_mv | AT diegogayosocantero changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT mariadolorescorbacholoarte changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT claracrespilloandujar changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT sandrachamorrotojeiro changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT francescanorman changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT joseaperezmolina changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT martagonzalezsanz changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT oihanemartin changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT josemiguelrubio changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT beatrizgullonpena changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT lauradelcampoalbendea changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT rogeliolopezvelez changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort AT begonamongemaillo changesinlipidprofilesecondarytoasymptomaticmalariainmigrantsfromsubsaharanafricaaretrospectiveanalysisofa20102022cohort |