Differential aging of growth plate cartilage underlies differences in bone length and thus helps determine skeletal proportions.

Bones at different anatomical locations vary dramatically in size. For example, human femurs are 20-fold longer than the phalanges in the fingers and toes. The mechanisms responsible for these size differences are poorly understood. Bone elongation occurs at the growth plates and advances rapidly in...

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Bibliographic Details
Main Authors: Julian C Lui, Youn Hee Jee, Presley Garrison, James R Iben, Shanna Yue, Michal Ad, Quang Nguyen, Bijal Kikani, Yoshiyuki Wakabayashi, Jeffrey Baron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2005263&type=printable
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