Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma
One hallmark of cancer is the degradation of the extracellular matrix (ECM), which is caused by proteinases. In oral cancers, matrix metalloproteinases (MMPs), especially MMP-9, are associated with this degradation. MMPs break down the ECM allowing cancer to spread; they also release various factors...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/920595 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551805415849984 |
|---|---|
| author | Suvi-Tuuli Vilen Tuula Salo Timo Sorsa Pia Nyberg |
| author_facet | Suvi-Tuuli Vilen Tuula Salo Timo Sorsa Pia Nyberg |
| author_sort | Suvi-Tuuli Vilen |
| collection | DOAJ |
| description | One hallmark of cancer is the degradation of the extracellular matrix (ECM), which is caused by proteinases. In oral cancers, matrix metalloproteinases (MMPs), especially MMP-9, are associated with this degradation. MMPs break down the ECM allowing cancer to spread; they also release various factors from their cryptic sites, including cytokines. These factors modulate cell behavior and enhance cancer progression by regulating angiogenesis, migration, proliferation, and invasion. The development of early metastases is typical for oral cancer, and increased MMP-9 expression is associated with a poor disease prognosis. However, many studies fail to relate MMP-9 expression with metastasis formation. Contrary to earlier models, recent studies show that MMP-9 plays a protective role in oral cancers. Therefore, the role of MMP-9 is complicated and may fluctuate throughout the different types and stages of oral cancers. |
| format | Article |
| id | doaj-art-5c69d648a8a14fa4988ac940eb092e26 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-5c69d648a8a14fa4988ac940eb092e262025-02-03T06:00:20ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/920595920595Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell CarcinomaSuvi-Tuuli Vilen0Tuula Salo1Timo Sorsa2Pia Nyberg3Biomedicum Helsinki, Institute of Dentistry, Research Laboratory, University of Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014 Helsinki, FinlandBiomedicum Helsinki, Institute of Dentistry, Research Laboratory, University of Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014 Helsinki, FinlandBiomedicum Helsinki, Institute of Dentistry, Research Laboratory, University of Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014 Helsinki, FinlandDepartment of Diagnostics and Oral Medicine, Institute of Dentistry and the Oulu Center for Cell-Matrix Research, University of Oulu, P.O. Box 5281, 90014 Oulu, FinlandOne hallmark of cancer is the degradation of the extracellular matrix (ECM), which is caused by proteinases. In oral cancers, matrix metalloproteinases (MMPs), especially MMP-9, are associated with this degradation. MMPs break down the ECM allowing cancer to spread; they also release various factors from their cryptic sites, including cytokines. These factors modulate cell behavior and enhance cancer progression by regulating angiogenesis, migration, proliferation, and invasion. The development of early metastases is typical for oral cancer, and increased MMP-9 expression is associated with a poor disease prognosis. However, many studies fail to relate MMP-9 expression with metastasis formation. Contrary to earlier models, recent studies show that MMP-9 plays a protective role in oral cancers. Therefore, the role of MMP-9 is complicated and may fluctuate throughout the different types and stages of oral cancers.http://dx.doi.org/10.1155/2013/920595 |
| spellingShingle | Suvi-Tuuli Vilen Tuula Salo Timo Sorsa Pia Nyberg Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma The Scientific World Journal |
| title | Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma |
| title_full | Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma |
| title_fullStr | Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma |
| title_short | Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma |
| title_sort | fluctuating roles of matrix metalloproteinase 9 in oral squamous cell carcinoma |
| url | http://dx.doi.org/10.1155/2013/920595 |
| work_keys_str_mv | AT suvituulivilen fluctuatingrolesofmatrixmetalloproteinase9inoralsquamouscellcarcinoma AT tuulasalo fluctuatingrolesofmatrixmetalloproteinase9inoralsquamouscellcarcinoma AT timosorsa fluctuatingrolesofmatrixmetalloproteinase9inoralsquamouscellcarcinoma AT pianyberg fluctuatingrolesofmatrixmetalloproteinase9inoralsquamouscellcarcinoma |