Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis

Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis

Podocyte loss in glomeruli is a fundamental event in the pathogenesis of chronic kidney diseases. Currently, mitotic catastrophe (MC) has emerged as the main cause of podocyte loss. However, the regulation of MC in podocytes has yet to be elucidated. The current work aimed to study the role and mech...

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Bibliographic Details
Main Authors: Jie Feng, Liyi Xie, Wanhong Lu, Xiaoyang Yu, Hongjuan Dong, Yuefeng Ma, Ranran Kong
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
CDK1
cyclin B1
p53
podocyte
mitotic catastrophe
Wee1
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2365408
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