The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget
Long non-coding RNAs (lncRNAs) are progressively being perceived as prominent molecular agents controlling multiple aspects of neuronal (patho)physiology. Amongst these is the HOX transcript antisense intergenic RNA, often abbreviated as HOTAIR. HOTAIR epigenetically regulates its target genes via i...
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Cambridge University Press
2024-01-01
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| Series: | Expert Reviews in Molecular Medicine |
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| author | Faraz Ahmad Ravi Sudesh Atheeq Toufeeq Ahmed Mohanapriya Arumugam Darin Mansor Mathkor Shafiul Haque |
| author_facet | Faraz Ahmad Ravi Sudesh Atheeq Toufeeq Ahmed Mohanapriya Arumugam Darin Mansor Mathkor Shafiul Haque |
| author_sort | Faraz Ahmad |
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| description | Long non-coding RNAs (lncRNAs) are progressively being perceived as prominent molecular agents controlling multiple aspects of neuronal (patho)physiology. Amongst these is the HOX transcript antisense intergenic RNA, often abbreviated as HOTAIR. HOTAIR epigenetically regulates its target genes via its interaction with two different chromatin-modifying agents; histone methyltransferase polycomb-repressive complex 2 and histone demethylase lysine-specific demethylase 1. Parenthetically, HOTAIR elicits trans-acting sponging function against multiple micro-RNA species. Oncological research studies have confirmed the pathogenic functions of HOTAIR in multiple cancer types, such as gliomas and proposed it as a pro-oncological lncRNA. In fact, its expression has been suggested to be a predictor of the severity/grade of gliomas, and as a prognostic biomarker. Moreover, a propound influence of HOTAIR in other aspects of brain heath and disease states is just beginning to be unravelled. The objective of this review is to recapitulate all the relevant data pertaining to the regulatory roles of HOTAIR in neuronal (patho)physiology. To this end, we discuss the pathogenic mechanisms of HOTAIR in multiple neuronal diseases, such as neurodegeneration, traumatic brain injury and neuropsychiatric disorders. Finally, we also summarize the results from the studies incriminating HOTAIR in the pathogeneses of gliomas and other brain cancers. Implications of HOTAIR serving as a suitable therapeutic target in neuropathologies are also discussed. |
| format | Article |
| id | doaj-art-5c64cfdd9d9e4893bc268416a9d4e545 |
| institution | Kabale University |
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| language | English |
| publishDate | 2024-01-01 |
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| spelling | doaj-art-5c64cfdd9d9e4893bc268416a9d4e5452025-08-20T12:57:31ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942024-01-012610.1017/erm.2024.11The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotargetFaraz Ahmad0https://orcid.org/0000-0003-4284-8045Ravi Sudesh1https://orcid.org/0000-0002-3338-718XAtheeq Toufeeq Ahmed2Mohanapriya Arumugam3Darin Mansor Mathkor4Shafiul Haque5https://orcid.org/0000-0002-2989-121XDepartment of Biotechnology, School of Bio Sciences (SBST), Vellore Institute of Technology (VIT), Vellore 632014, IndiaDepartment of Biomedical Sciences, School of Bio Sciences (SBST), Vellore Institute of Technology (VIT), Vellore 632014, IndiaDepartment of Biotechnology, School of Bio Sciences (SBST), Vellore Institute of Technology (VIT), Vellore 632014, IndiaDepartment of Biotechnology, School of Bio Sciences (SBST), Vellore Institute of Technology (VIT), Vellore 632014, IndiaResearch and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi ArabiaResearch and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, LebanonLong non-coding RNAs (lncRNAs) are progressively being perceived as prominent molecular agents controlling multiple aspects of neuronal (patho)physiology. Amongst these is the HOX transcript antisense intergenic RNA, often abbreviated as HOTAIR. HOTAIR epigenetically regulates its target genes via its interaction with two different chromatin-modifying agents; histone methyltransferase polycomb-repressive complex 2 and histone demethylase lysine-specific demethylase 1. Parenthetically, HOTAIR elicits trans-acting sponging function against multiple micro-RNA species. Oncological research studies have confirmed the pathogenic functions of HOTAIR in multiple cancer types, such as gliomas and proposed it as a pro-oncological lncRNA. In fact, its expression has been suggested to be a predictor of the severity/grade of gliomas, and as a prognostic biomarker. Moreover, a propound influence of HOTAIR in other aspects of brain heath and disease states is just beginning to be unravelled. The objective of this review is to recapitulate all the relevant data pertaining to the regulatory roles of HOTAIR in neuronal (patho)physiology. To this end, we discuss the pathogenic mechanisms of HOTAIR in multiple neuronal diseases, such as neurodegeneration, traumatic brain injury and neuropsychiatric disorders. Finally, we also summarize the results from the studies incriminating HOTAIR in the pathogeneses of gliomas and other brain cancers. Implications of HOTAIR serving as a suitable therapeutic target in neuropathologies are also discussed.https://www.cambridge.org/core/product/identifier/S1462399424000115/type/journal_articlebrain injuryceRNAgliomaneurodegenerationneuropsychological conditions |
| spellingShingle | Faraz Ahmad Ravi Sudesh Atheeq Toufeeq Ahmed Mohanapriya Arumugam Darin Mansor Mathkor Shafiul Haque The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget Expert Reviews in Molecular Medicine brain injury ceRNA glioma neurodegeneration neuropsychological conditions |
| title | The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget |
| title_full | The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget |
| title_fullStr | The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget |
| title_full_unstemmed | The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget |
| title_short | The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget |
| title_sort | multifaceted functions of long non coding rna hotair in neuropathologies and its potential as a prognostic marker and therapeutic biotarget |
| topic | brain injury ceRNA glioma neurodegeneration neuropsychological conditions |
| url | https://www.cambridge.org/core/product/identifier/S1462399424000115/type/journal_article |
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