Blood levels of PAF are elevated during induction of immune complex mediated enteropathy in the rat
Intravenous injection into rats of immune complexes (IC) prepared in 5 × antigen excess rapidly induces annular bands of vascular congestion and transmural haemorrhage producing a striped appearance of the small intestine. Indirect evidence suggested a major role for PAF in the induction of lesions....
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000516 |
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| _version_ | 1849413159185547264 |
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| author | K. J. Bloch B. P. Ng M. Bloch |
| author_facet | K. J. Bloch B. P. Ng M. Bloch |
| author_sort | K. J. Bloch |
| collection | DOAJ |
| description | Intravenous injection into rats of immune complexes (IC) prepared in 5 × antigen excess rapidly induces annular bands of vascular congestion and transmural haemorrhage producing a striped appearance of the small intestine. Indirect evidence suggested a major role for PAF in the induction of lesions. In the present study, we showed that blood and leukocyte levels of PAF were elevated in most rats injected 10 min earlier with sufficient IC to induce lesions of 3+ to 4+ intensity. There was no significant difference in the number of rats with elevated plasma levels of PAF. The possibility that changes in blood PAF levels might be mirrored at sites closer to the lesions was considered. The overall effect of PAF on the small intestine of the rats is to induce stasis of flow; the precise target of PAF in mediating this effect is unknown. |
| format | Article |
| id | doaj-art-5c6311aafc8d463ba17cb9c42f4f6df2 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5c6311aafc8d463ba17cb9c42f4f6df22025-08-20T03:34:13ZengWileyMediators of Inflammation0962-93511466-18611992-01-011534134510.1155/S0962935192000516Blood levels of PAF are elevated during induction of immune complex mediated enteropathy in the ratK. J. Bloch0B. P. Ng1M. Bloch2Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Fruit Street, Bulfinch 422, Boston, MA 02114, USAClinical Immunology and Allergy Units, General Medical Services, Massachusetts General Hospital, Fruit Street, Bulfinch 422, Boston, MA 02114, USAClinical Immunology and Allergy Units, General Medical Services, Massachusetts General Hospital, Fruit Street, Bulfinch 422, Boston, MA 02114, USAIntravenous injection into rats of immune complexes (IC) prepared in 5 × antigen excess rapidly induces annular bands of vascular congestion and transmural haemorrhage producing a striped appearance of the small intestine. Indirect evidence suggested a major role for PAF in the induction of lesions. In the present study, we showed that blood and leukocyte levels of PAF were elevated in most rats injected 10 min earlier with sufficient IC to induce lesions of 3+ to 4+ intensity. There was no significant difference in the number of rats with elevated plasma levels of PAF. The possibility that changes in blood PAF levels might be mirrored at sites closer to the lesions was considered. The overall effect of PAF on the small intestine of the rats is to induce stasis of flow; the precise target of PAF in mediating this effect is unknown.http://dx.doi.org/10.1155/S0962935192000516 |
| spellingShingle | K. J. Bloch B. P. Ng M. Bloch Blood levels of PAF are elevated during induction of immune complex mediated enteropathy in the rat Mediators of Inflammation |
| title | Blood levels of PAF are elevated during induction of immune complex mediated enteropathy in the rat |
| title_full | Blood levels of PAF are elevated during induction of immune complex mediated enteropathy in the rat |
| title_fullStr | Blood levels of PAF are elevated during induction of immune complex mediated enteropathy in the rat |
| title_full_unstemmed | Blood levels of PAF are elevated during induction of immune complex mediated enteropathy in the rat |
| title_short | Blood levels of PAF are elevated during induction of immune complex mediated enteropathy in the rat |
| title_sort | blood levels of paf are elevated during induction of immune complex mediated enteropathy in the rat |
| url | http://dx.doi.org/10.1155/S0962935192000516 |
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