Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor
Cell adhesion molecules (CAMs) are cell surface glycoproteins mediating interactions of cells with other cells and the extracellular matrix. By mediating the adhesion and modulating activity of other plasma membrane proteins, CAMs are involved in regulating a multitude of cellular processes, includi...
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MDPI AG
2024-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/22/1919 |
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| author | Irina Kozlova Vladimir Sytnyk |
| author_facet | Irina Kozlova Vladimir Sytnyk |
| author_sort | Irina Kozlova |
| collection | DOAJ |
| description | Cell adhesion molecules (CAMs) are cell surface glycoproteins mediating interactions of cells with other cells and the extracellular matrix. By mediating the adhesion and modulating activity of other plasma membrane proteins, CAMs are involved in regulating a multitude of cellular processes, including growth, proliferation, migration, and survival of cells. In this review, we present evidence showing that various CAMs interact with the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase inducing pro-proliferative and anti-apoptotic intracellular signaling in response to binding to several soluble ligands, including the epidermal growth factor. We discuss that CAMs are involved in regulating EGFR signaling by either potentiating or inhibiting the soluble ligand-dependent activation of EGFR. In addition, CAMs induce soluble ligand-independent forms of EGFR activity and regulate the levels of EGFR and its ligand-induced degradation. The CAM-dependent modulation of EGFR activity plays a key role in regulating the growth, proliferation, and survival of cells. Future research is needed to determine whether these processes can be targeted in both normal and cancerous cells by regulating interactions of EGFR with various CAMs. |
| format | Article |
| id | doaj-art-5c54cc42ed2c4fc7a5b40ffabc75c7f3 |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-5c54cc42ed2c4fc7a5b40ffabc75c7f32025-08-20T01:53:53ZengMDPI AGCells2073-44092024-11-011322191910.3390/cells13221919Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor ReceptorIrina Kozlova0Vladimir Sytnyk1School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, AustraliaCell adhesion molecules (CAMs) are cell surface glycoproteins mediating interactions of cells with other cells and the extracellular matrix. By mediating the adhesion and modulating activity of other plasma membrane proteins, CAMs are involved in regulating a multitude of cellular processes, including growth, proliferation, migration, and survival of cells. In this review, we present evidence showing that various CAMs interact with the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase inducing pro-proliferative and anti-apoptotic intracellular signaling in response to binding to several soluble ligands, including the epidermal growth factor. We discuss that CAMs are involved in regulating EGFR signaling by either potentiating or inhibiting the soluble ligand-dependent activation of EGFR. In addition, CAMs induce soluble ligand-independent forms of EGFR activity and regulate the levels of EGFR and its ligand-induced degradation. The CAM-dependent modulation of EGFR activity plays a key role in regulating the growth, proliferation, and survival of cells. Future research is needed to determine whether these processes can be targeted in both normal and cancerous cells by regulating interactions of EGFR with various CAMs.https://www.mdpi.com/2073-4409/13/22/1919cell adhesioncell proliferationapoptosiscancerintegrinscadherins |
| spellingShingle | Irina Kozlova Vladimir Sytnyk Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor Cells cell adhesion cell proliferation apoptosis cancer integrins cadherins |
| title | Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor |
| title_full | Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor |
| title_fullStr | Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor |
| title_full_unstemmed | Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor |
| title_short | Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor |
| title_sort | cell adhesion molecules as modulators of the epidermal growth factor receptor |
| topic | cell adhesion cell proliferation apoptosis cancer integrins cadherins |
| url | https://www.mdpi.com/2073-4409/13/22/1919 |
| work_keys_str_mv | AT irinakozlova celladhesionmoleculesasmodulatorsoftheepidermalgrowthfactorreceptor AT vladimirsytnyk celladhesionmoleculesasmodulatorsoftheepidermalgrowthfactorreceptor |