Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography
Purpose. To assess the repeatability of spectral-domain optical coherence tomography to measure macular and perimacular ganglion cell complex thicknesses and compare retinal ganglion cell parameters between algorithms. Methods. Ninety-two nonglaucomatous eyes from 92 participants underwent macular a...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/605940 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849413152981123072 |
|---|---|
| author | Dorothy S. K. Ng Preeti Gupta Yih Chung Tham Chye Fong Peck Tien Yin Wong Mohammad Kamran Ikram Carol Y. Cheung |
| author_facet | Dorothy S. K. Ng Preeti Gupta Yih Chung Tham Chye Fong Peck Tien Yin Wong Mohammad Kamran Ikram Carol Y. Cheung |
| author_sort | Dorothy S. K. Ng |
| collection | DOAJ |
| description | Purpose. To assess the repeatability of spectral-domain optical coherence tomography to measure macular and perimacular ganglion cell complex thicknesses and compare retinal ganglion cell parameters between algorithms. Methods. Ninety-two nonglaucomatous eyes from 92 participants underwent macular and perimacular ganglion cell complex thickness measurement using OCT-HS100 Glaucoma 3D algorithm and these measurements were repeated for 34 subjects. All subjects also had macular ganglion cell-inner plexiform layer thickness measured by Cirrus HD-OCT Ganglion Cell Analysis algorithm. Intraclass correlation coefficient and Pearson’s correlation analyses were performed. Results. Subfields of both macular and perimacular ganglion cell complex thicknesses had high intraclass correlation coefficient values between 0.979 (95% confidence interval [CI]: 0.958–0.989) and 0.981 (95% CI: 0.963, 0.991) and between 0.70 (95% CI: 0.481–0.838) and 0.987 (95% CI: 0.956–0.989), respectively. The overall average ganglion cell complex and macular average ganglion cell-inner plexiform layer thicknesses were strongly correlated (r=0.83, P<0.001). Conclusions. The assessment of macular and perimacular retinal ganglion cell parameters by OCT-HS100 Glaucoma 3D algorithm is highly repeatable, and strongly correlates to retinal ganglion cell parameters assessed by Ganglion Cell Analysis algorithm. A comprehensive evaluation of retinal ganglion cells may be possible with OCT-HS100. |
| format | Article |
| id | doaj-art-5c4e199ec52f494eac96a2af9ab7225f |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-5c4e199ec52f494eac96a2af9ab7225f2025-08-20T03:34:13ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/605940605940Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence TomographyDorothy S. K. Ng0Preeti Gupta1Yih Chung Tham2Chye Fong Peck3Tien Yin Wong4Mohammad Kamran Ikram5Carol Y. Cheung6Singapore Eye Research Institute, Singapore National Eye Centre, 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, 169856, SingaporePurpose. To assess the repeatability of spectral-domain optical coherence tomography to measure macular and perimacular ganglion cell complex thicknesses and compare retinal ganglion cell parameters between algorithms. Methods. Ninety-two nonglaucomatous eyes from 92 participants underwent macular and perimacular ganglion cell complex thickness measurement using OCT-HS100 Glaucoma 3D algorithm and these measurements were repeated for 34 subjects. All subjects also had macular ganglion cell-inner plexiform layer thickness measured by Cirrus HD-OCT Ganglion Cell Analysis algorithm. Intraclass correlation coefficient and Pearson’s correlation analyses were performed. Results. Subfields of both macular and perimacular ganglion cell complex thicknesses had high intraclass correlation coefficient values between 0.979 (95% confidence interval [CI]: 0.958–0.989) and 0.981 (95% CI: 0.963, 0.991) and between 0.70 (95% CI: 0.481–0.838) and 0.987 (95% CI: 0.956–0.989), respectively. The overall average ganglion cell complex and macular average ganglion cell-inner plexiform layer thicknesses were strongly correlated (r=0.83, P<0.001). Conclusions. The assessment of macular and perimacular retinal ganglion cell parameters by OCT-HS100 Glaucoma 3D algorithm is highly repeatable, and strongly correlates to retinal ganglion cell parameters assessed by Ganglion Cell Analysis algorithm. A comprehensive evaluation of retinal ganglion cells may be possible with OCT-HS100.http://dx.doi.org/10.1155/2015/605940 |
| spellingShingle | Dorothy S. K. Ng Preeti Gupta Yih Chung Tham Chye Fong Peck Tien Yin Wong Mohammad Kamran Ikram Carol Y. Cheung Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography Journal of Ophthalmology |
| title | Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography |
| title_full | Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography |
| title_fullStr | Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography |
| title_full_unstemmed | Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography |
| title_short | Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography |
| title_sort | repeatability of perimacular ganglion cell complex analysis with spectral domain optical coherence tomography |
| url | http://dx.doi.org/10.1155/2015/605940 |
| work_keys_str_mv | AT dorothyskng repeatabilityofperimacularganglioncellcomplexanalysiswithspectraldomainopticalcoherencetomography AT preetigupta repeatabilityofperimacularganglioncellcomplexanalysiswithspectraldomainopticalcoherencetomography AT yihchungtham repeatabilityofperimacularganglioncellcomplexanalysiswithspectraldomainopticalcoherencetomography AT chyefongpeck repeatabilityofperimacularganglioncellcomplexanalysiswithspectraldomainopticalcoherencetomography AT tienyinwong repeatabilityofperimacularganglioncellcomplexanalysiswithspectraldomainopticalcoherencetomography AT mohammadkamranikram repeatabilityofperimacularganglioncellcomplexanalysiswithspectraldomainopticalcoherencetomography AT carolycheung repeatabilityofperimacularganglioncellcomplexanalysiswithspectraldomainopticalcoherencetomography |