Atypical Psychiatric Manifestation of Primary Wilson’s Disease: A Case Report
Background: Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism. It is associated with <italic>ATP7B</italic> gene mutations, present on chromosome 13. It is primarily a liver disease, but presentation varies according to copper deposition in various organs. The...
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| Language: | English |
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Jaypee Brothers Medical Publisher
2022-03-01
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| Series: | Indian Journal of Private Psychiatry |
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| Online Access: | https://www.ijiapp.com/doi/IJPP/pdf/10.5005/jp-journals-10067-0096 |
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| author | Subramanyam M Sanjiv Chamraj Khushboo Dewani Preeti Srinivasa |
| author_facet | Subramanyam M Sanjiv Chamraj Khushboo Dewani Preeti Srinivasa |
| author_sort | Subramanyam M |
| collection | DOAJ |
| description | Background: Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism. It is associated with <italic>ATP7B</italic> gene mutations, present on chromosome 13. It is primarily a liver disease, but presentation varies according to copper deposition in various organs. The diagnosis depends on clinical features, Kayser–Fleischer rings, biochemical parameters, radiological findings, liver biopsy, and gene analysis.
Case: We report an atypical presentation of WD, where the patient presented with only psychiatric manifestations with two episodes of mania with duration of 3 years to evolve from psychiatric manifestations to neurological and hepatic manifestations of WD.
Conclusion: A high index of suspicion is required, and early recognition of atypical presentation and initiation of the treatment can prevent a catastrophic outcome. |
| format | Article |
| id | doaj-art-5c4a431056f142768dfbfde79f7fbe5e |
| institution | DOAJ |
| issn | 2319-5363 2583-4010 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Private Psychiatry |
| spelling | doaj-art-5c4a431056f142768dfbfde79f7fbe5e2025-08-20T03:18:18ZengJaypee Brothers Medical PublisherIndian Journal of Private Psychiatry2319-53632583-40102022-03-01161343710.5005/jp-journals-10067-00967Atypical Psychiatric Manifestation of Primary Wilson’s Disease: A Case ReportSubramanyam M0https://orcid.org/0000-0001-6837-3442Sanjiv Chamraj1https://orcid.org/0000-0002-4325-7151Khushboo Dewani2Preeti Srinivasa3https://orcid.org/0000-0001-9911-7927Sanjiv Chamraj, Department of Neurology, Spandana Nursing Home, Bengaluru, Karnataka, India, Phone: +91 9945840180Sanjiv Chamraj, Department of Neurology, Spandana Nursing Home, Bengaluru, Karnataka, India, Phone: +91 9945840180Department of Psychiatry, S Nijalingappa Medical College and HSK Hospital, Bengaluru, Karnataka, IndiaDepartment of Psychiatry, Spandana Nursing Home, Bengaluru, Karnataka, IndiaBackground: Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism. It is associated with <italic>ATP7B</italic> gene mutations, present on chromosome 13. It is primarily a liver disease, but presentation varies according to copper deposition in various organs. The diagnosis depends on clinical features, Kayser–Fleischer rings, biochemical parameters, radiological findings, liver biopsy, and gene analysis. Case: We report an atypical presentation of WD, where the patient presented with only psychiatric manifestations with two episodes of mania with duration of 3 years to evolve from psychiatric manifestations to neurological and hepatic manifestations of WD. Conclusion: A high index of suspicion is required, and early recognition of atypical presentation and initiation of the treatment can prevent a catastrophic outcome.https://www.ijiapp.com/doi/IJPP/pdf/10.5005/jp-journals-10067-0096bipolar affective disorderextrapyramidal side effectsirritabilityrigiditytremors |
| spellingShingle | Subramanyam M Sanjiv Chamraj Khushboo Dewani Preeti Srinivasa Atypical Psychiatric Manifestation of Primary Wilson’s Disease: A Case Report Indian Journal of Private Psychiatry bipolar affective disorder extrapyramidal side effects irritability rigidity tremors |
| title | Atypical Psychiatric Manifestation of Primary Wilson’s Disease: A Case Report |
| title_full | Atypical Psychiatric Manifestation of Primary Wilson’s Disease: A Case Report |
| title_fullStr | Atypical Psychiatric Manifestation of Primary Wilson’s Disease: A Case Report |
| title_full_unstemmed | Atypical Psychiatric Manifestation of Primary Wilson’s Disease: A Case Report |
| title_short | Atypical Psychiatric Manifestation of Primary Wilson’s Disease: A Case Report |
| title_sort | atypical psychiatric manifestation of primary wilson s disease a case report |
| topic | bipolar affective disorder extrapyramidal side effects irritability rigidity tremors |
| url | https://www.ijiapp.com/doi/IJPP/pdf/10.5005/jp-journals-10067-0096 |
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