In Vivo Confocal Microscopy of Cornea in Patients with Terrien’s Marginal Corneal Degeneration
This study was aimed at observing the morphological changes of the cornea with ocular in vivo confocal microscopy (IVCM) in patients with Terrien’s marginal degeneration (TMD). Ten patients (20 eyes) with TMD treated in the Department of Ophthalmology, Xiangya Hospital, and 10 healthy controls (20 e...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/3161843 |
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| author | Ting Chen Qiangxiang Li Xiangbo Tang Min Liao Hua Wang |
| author_facet | Ting Chen Qiangxiang Li Xiangbo Tang Min Liao Hua Wang |
| author_sort | Ting Chen |
| collection | DOAJ |
| description | This study was aimed at observing the morphological changes of the cornea with ocular in vivo confocal microscopy (IVCM) in patients with Terrien’s marginal degeneration (TMD). Ten patients (20 eyes) with TMD treated in the Department of Ophthalmology, Xiangya Hospital, and 10 healthy controls (20 eyes) were included in the current study. A detailed slit lamp microscopy, anterior segment photography, and corneal IVCM examination were performed for each eye. The density of central and marginal corneal epithelial cells, stromal cells, and subepithelial nerve fibers was compared between the two groups using the Wilcoxon rank sum test. Compared with the control group, the corneal epithelial and endothelial cells in the TMD group showed granular highly reflective substances and thinner subepithelial nerve fibers. The uneven dot-like highly reflective substances without cell structures appeared in the stromal layer of the cornea. The density of central and marginal corneal epithelial cells, stromal cells, and subepithelial nerve fibers was lower in the TMD group (p<0.05), and they were negatively correlated with severity of the disease (p<0.05). Our study demonstrated that the density of corneal epithelial cells, stromal cells, and sensory plexus nerve fibers was significantly reduced in the TMD group. The pathological changes were more obvious in the marginal cornea, and it is correlated with severity of the disease. |
| format | Article |
| id | doaj-art-5c4861a7bf8a49eeb11551f6cad1a2e3 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-5c4861a7bf8a49eeb11551f6cad1a2e32025-02-03T00:59:23ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/31618433161843In Vivo Confocal Microscopy of Cornea in Patients with Terrien’s Marginal Corneal DegenerationTing Chen0Qiangxiang Li1Xiangbo Tang2Min Liao3Hua Wang4Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan Province, ChinaHunan Provincial People’s Hospital, Changsha, Hunan Province, ChinaDepartment of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan Province, ChinaDepartment of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan Province, ChinaDepartment of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan Province, ChinaThis study was aimed at observing the morphological changes of the cornea with ocular in vivo confocal microscopy (IVCM) in patients with Terrien’s marginal degeneration (TMD). Ten patients (20 eyes) with TMD treated in the Department of Ophthalmology, Xiangya Hospital, and 10 healthy controls (20 eyes) were included in the current study. A detailed slit lamp microscopy, anterior segment photography, and corneal IVCM examination were performed for each eye. The density of central and marginal corneal epithelial cells, stromal cells, and subepithelial nerve fibers was compared between the two groups using the Wilcoxon rank sum test. Compared with the control group, the corneal epithelial and endothelial cells in the TMD group showed granular highly reflective substances and thinner subepithelial nerve fibers. The uneven dot-like highly reflective substances without cell structures appeared in the stromal layer of the cornea. The density of central and marginal corneal epithelial cells, stromal cells, and subepithelial nerve fibers was lower in the TMD group (p<0.05), and they were negatively correlated with severity of the disease (p<0.05). Our study demonstrated that the density of corneal epithelial cells, stromal cells, and sensory plexus nerve fibers was significantly reduced in the TMD group. The pathological changes were more obvious in the marginal cornea, and it is correlated with severity of the disease.http://dx.doi.org/10.1155/2019/3161843 |
| spellingShingle | Ting Chen Qiangxiang Li Xiangbo Tang Min Liao Hua Wang In Vivo Confocal Microscopy of Cornea in Patients with Terrien’s Marginal Corneal Degeneration Journal of Ophthalmology |
| title | In Vivo Confocal Microscopy of Cornea in Patients with Terrien’s Marginal Corneal Degeneration |
| title_full | In Vivo Confocal Microscopy of Cornea in Patients with Terrien’s Marginal Corneal Degeneration |
| title_fullStr | In Vivo Confocal Microscopy of Cornea in Patients with Terrien’s Marginal Corneal Degeneration |
| title_full_unstemmed | In Vivo Confocal Microscopy of Cornea in Patients with Terrien’s Marginal Corneal Degeneration |
| title_short | In Vivo Confocal Microscopy of Cornea in Patients with Terrien’s Marginal Corneal Degeneration |
| title_sort | in vivo confocal microscopy of cornea in patients with terrien s marginal corneal degeneration |
| url | http://dx.doi.org/10.1155/2019/3161843 |
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