Collection and Transplantation of Peripheral Blood Stem Cells in Children: A Single-Center Experience
Background/Aims: As a source of hematopoietic stem cells, peripheral blood stem cells have been used more frequently in both malignant and non-malignant diseases. There are some difficulties in the collection of PBSC from children compared to adults such as vascular access a...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2024-06-01
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| Series: | Genel Tıp Dergisi |
| Online Access: | https://dergipark.org.tr/tr/doi/10.54005/geneltip.1386100 |
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| author | Cengiz Zeybek Orhan Gürsel Ahmet Bolat İbrahim Eker Erman Atas Ahmet Emin Kürekçi |
| author_facet | Cengiz Zeybek Orhan Gürsel Ahmet Bolat İbrahim Eker Erman Atas Ahmet Emin Kürekçi |
| author_sort | Cengiz Zeybek |
| collection | DOAJ |
| description |
Background/Aims: As a source of hematopoietic stem cells, peripheral blood stem cells have been used more frequently in both malignant and non-malignant diseases. There are some difficulties in the collection of PBSC from children compared to adults such as vascular access and, extracorporeal circuit volume, especially in small children.Methods: In this study, we present our experience in 63 children who underwent peripheral blood stem cell collection and transplantation between November 2016 and September 2023. Results: The median age and weight of the children at the time of apheresis procedures were 10.25 years and 34 kg, respectively. Of 63 peripheral blood stem cell collection and transplantations, 48 were autologous and 15 were allogeneic. The median cell yield per apheresis procedure was 2.6 x 106 CD34+ cells/kg (0.6-9.66). Four of the total 63 patients and donors required multiple apheresis procedures. No significant side effects were observed after apheresis procedures. Conclusions: We observed that in experienced hands, peripheral blood stem cell collection and transplantation in children is at least as safe and effective as in adults. |
| format | Article |
| id | doaj-art-5c445e2bcda4410e9d66997293228291 |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-5c445e2bcda4410e9d669972932282912025-01-03T01:52:47ZengSelcuk University PressGenel Tıp Dergisi2602-37412024-06-0134330130510.54005/geneltip.1386100 Collection and Transplantation of Peripheral Blood Stem Cells in Children: A Single-Center Experience Cengiz Zeybek0https://orcid.org/0000-0002-4820-0373Orhan Gürsel1https://orcid.org/0000-0002-2077-8093Ahmet Bolat2https://orcid.org/0000-0001-6653-0045İbrahim Eker3Erman Atas4https://orcid.org/0000-0002-6758-6208Ahmet Emin Kürekçi5https://orcid.org/0000-0003-3259-220XUNIVERSITY OF HEALTH SCIENCES, GÜLHANE SCHOOL OF MEDICINE, GÜLHANE MEDICINE PR. (ANKARA)UNIVERSITY OF HEALTH SCIENCES, GÜLHANE SCHOOL OF MEDICINE, GÜLHANE MEDICINE PR. (ANKARA)UNIVERSITY OF HEALTH SCIENCES, GÜLHANE SCHOOL OF MEDICINE, GÜLHANE MEDICINE PR. (ANKARA)AFYON KOCATEPE UNIVERSITYUNIVERSITY OF HEALTH SCIENCES, GÜLHANE SCHOOL OF MEDICINE, GÜLHANE MEDICINE PR. (ANKARA)Lösante Hospital Background/Aims: As a source of hematopoietic stem cells, peripheral blood stem cells have been used more frequently in both malignant and non-malignant diseases. There are some difficulties in the collection of PBSC from children compared to adults such as vascular access and, extracorporeal circuit volume, especially in small children.Methods: In this study, we present our experience in 63 children who underwent peripheral blood stem cell collection and transplantation between November 2016 and September 2023. Results: The median age and weight of the children at the time of apheresis procedures were 10.25 years and 34 kg, respectively. Of 63 peripheral blood stem cell collection and transplantations, 48 were autologous and 15 were allogeneic. The median cell yield per apheresis procedure was 2.6 x 106 CD34+ cells/kg (0.6-9.66). Four of the total 63 patients and donors required multiple apheresis procedures. No significant side effects were observed after apheresis procedures. Conclusions: We observed that in experienced hands, peripheral blood stem cell collection and transplantation in children is at least as safe and effective as in adults.https://dergipark.org.tr/tr/doi/10.54005/geneltip.1386100 |
| spellingShingle | Cengiz Zeybek Orhan Gürsel Ahmet Bolat İbrahim Eker Erman Atas Ahmet Emin Kürekçi Collection and Transplantation of Peripheral Blood Stem Cells in Children: A Single-Center Experience Genel Tıp Dergisi |
| title |
Collection and Transplantation of Peripheral Blood Stem Cells in Children: A Single-Center Experience
|
| title_full |
Collection and Transplantation of Peripheral Blood Stem Cells in Children: A Single-Center Experience
|
| title_fullStr |
Collection and Transplantation of Peripheral Blood Stem Cells in Children: A Single-Center Experience
|
| title_full_unstemmed |
Collection and Transplantation of Peripheral Blood Stem Cells in Children: A Single-Center Experience
|
| title_short |
Collection and Transplantation of Peripheral Blood Stem Cells in Children: A Single-Center Experience
|
| title_sort | collection and transplantation of peripheral blood stem cells in children a single center experience |
| url | https://dergipark.org.tr/tr/doi/10.54005/geneltip.1386100 |
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